Journal
CNS NEUROSCIENCE & THERAPEUTICS
Volume 21, Issue 6, Pages 479-485Publisher
WILEY
DOI: 10.1111/cns.12387
Keywords
Alzheimer's disease; Nogo-A; Nogo-A receptor
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Funding
- Macao Science and Technology Development Fund [102/2012/A3]
- University of Macau [MYRG2014-00033-ICMS-QRCM, MYRG2014-00051-ICMS-QRCM, MRG005/CMW/2014/ICMS]
- Natural Science Foundation of China [81202519, 81403120]
- Guangdong Province [S2011040002140]
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Nogo-A is a protein inhibiting axonal regeneration, which is considered a major obstacle to nerve regeneration after injury in mammals. Rapid progress has been achieved in new physiopathological function of Nogo-A in Alzheimer's disease in the past decade. Recent research shows that through binding to Nogo-A receptor, Nogo-A plays an important role in Alzheimer's disease (AD) pathogenesis. Particularly, Nogo-A/Nogo-A receptors modulate the generation of amyloid -protein (A), which is thought to be a major cause of AD. This review describes the recent development of Nogo-A, Nogo-A receptor, and downstream signaling involved in AD and pharmacological basis of therapeutic drugs. We concluded the Nogo-A/Nogo-A receptor provide new insight into potential mechanisms and promising therapy strategies in AD.
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