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CHEMICAL COMMUNICATIONS
Volume -, Issue -, Pages -Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/d3cc05143a
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A novel method for the synthesis of quindoline derivatives using intramolecular ring-closure reactions and an iminium salt intermediate has been developed. This method offers the advantages of short reaction time, operational simplicity, and nearly quantitative yields, making it suitable for the rapid synthesis of valuable quindoline derivatives.
Construction of the pyridine ring is a practical and streamline way to construct a variety of quindoline derivatives. We have developed a novel method for synthesis of quindoline derivatives by means of intramolecular ring-closure reactions of 3-N-methylphenylindoles via an iminium salt intermediate. This practical method has the advantages of a short reaction time, operational simplicity, and nearly quantitative yields; and it can be used for the rapid synthesis of a variety of valuable quindoline derivatives. A method for synthesis of quindoline derivatives by means of intramolecular ring-closure reactions of 3-N-methylphenylindoles via an iminium salt intermediate was developed. This method can be used for the rapid synthesis of quindoline derivatives.
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