4.3 Article

Pharmacokinetics and pharmacodynamics of cannabis-based medicine in a patient population included in a randomized, placebo-controlled, clinical trial

Related references

Note: Only part of the references are listed.
Article Chemistry, Medicinal

Cannabis-Based Medicine for Neuropathic Pain and Spasticity-A Multicenter, Randomized, Double-Blinded, Placebo-Controlled Trial

Julie Schjodtz Hansen et al.

Summary: This study investigated the effect of cannabis-based medicine (CBM) on central neuropathic pain (NP) and spasticity in patients with multiple sclerosis (MS) and spinal cord injury (SCI). The results showed that THC, CBD, or their combination did not have a significant effect on pain and spasticity. The study was limited by a smaller sample size due to COVID-19 and recruitment challenges.

PHARMACEUTICALS (2023)

Review Medicine, General & Internal

Placebo Response and Media Attention in Randomized Clinical Trials Assessing Cannabis-Based Therapies for Pain A Systematic Review and Meta-analysis

Filip Gedin et al.

Summary: This study aimed to evaluate the size of placebo responses in randomized clinical trials comparing cannabinoids with placebo for pain treatment and correlate these responses with media attention. The results showed that placebo contributed significantly to pain reduction in cannabinoid clinical trials. The high media attention and dissemination may influence expectations and placebo responses in future trials, affecting clinical trial outcomes and patient access to cannabinoid pain relief.

JAMA NETWORK OPEN (2022)

Article Pharmacology & Pharmacy

Cannabinoid Interactions with Cytochrome P450 Drug Metabolism: a Full-Spectrum Characterization

Peter T. Doohan et al.

Summary: The use of medicinal cannabis has increased significantly with global legalization, leading to concerns about drug-drug interactions (DDIs). A study evaluating the inhibitory potential of 12 cannabinoids on drug metabolism showed that most cannabinoids inhibit CYP2C9, with limited effects on other CYP isoforms. In vivo DDI studies may be justified for CYP2C9 substrates with a narrow therapeutic index.

AAPS JOURNAL (2021)

Article Neurosciences

The Effect of Cannabis-Based Medicine on Neuropathic Pain and Spasticity in Patients with Multiple Sclerosis and Spinal Cord Injury: Study Protocol of a National Multicenter Double-Blinded, Placebo-Controlled Trial

Julie Schjodtz Hansen et al.

Summary: This study examines the effects of cannabis-based medicine (CBM) on spasticity and neuropathic pain caused by diseases or acquired damage to the central nervous system. Using a double-blind, parallel design in a national multicenter cohort, patients are randomized to receive capsules containing THC, CBD, THC and CBD, or placebo. The study also includes a sub-study to examine the pharmacodynamics and pharmacokinetics of oral capsule CBM.

BRAIN SCIENCES (2021)

Review Anesthesiology

Cannabinoids, cannabis, and cannabis-based medicines for pain management: an overview of systematic reviews

R. Andrew Moore et al.

Summary: Systematic reviews on the efficacy and safety of cannabinoids, cannabis, and cannabis-based medicines in managing pain are generally of low quality and cannot be relied upon for decision-making. Current reviews lack quality and a new high-quality systematic review of randomized controlled trials is needed to critically assess the clinical evidence for these treatments in pain management.
Review Anesthesiology

Cannabinoids, cannabis, and cannabis-based medicine for pain management: a systematic review of randomised controlled trials

Emma Fisher et al.

Summary: The efficacy and safety of cannabinoids, cannabis, and cannabis-based medicines for pain management remain uncertain and controversial, with most studies in this field having low-quality evidence and high risk of bias. The lack of confidence in effect estimates suggests that further research is needed in order to determine the true benefits and risks associated with these treatments.
Review Pharmacology & Pharmacy

The Placebo Effect in Pain Therapies

Luana Colloca

ANNUAL REVIEW OF PHARMACOLOGY AND TOXICOLOGY, VOL 59 (2019)

Article Computer Science, Interdisciplinary Applications

The REDCap consortium: Building an international community of software platform partners

Paul A. Harris et al.

JOURNAL OF BIOMEDICAL INFORMATICS (2019)

Review Pharmacology & Pharmacy

The pharmacokinetics and the pharmacodynamics of cannabinoids

Catherine J. Lucas et al.

BRITISH JOURNAL OF CLINICAL PHARMACOLOGY (2018)

Review Medicine, General & Internal

Multiple sclerosis

Alan J. Thompson et al.

LANCET (2018)

Review Pharmacology & Pharmacy

A Systematic Review on the Pharmacokinetics of Cannabidiol in Humans

Sophie A. Millar et al.

FRONTIERS IN PHARMACOLOGY (2018)

Review Pharmacology & Pharmacy

Cannabinoids and Pain: New Insights From Old Molecules

Sonja Vuckovic et al.

FRONTIERS IN PHARMACOLOGY (2018)

Article Chemistry, Analytical

Sensitive Determination of Cannabinoids in Whole Blood by LC-MS-MS After Rapid Removal of Phospholipids by Filtration

Lambert K. Sorensen et al.

JOURNAL OF ANALYTICAL TOXICOLOGY (2017)

Review Pharmacology & Pharmacy

Cannabis and Pain: A Clinical Review

Kevin P. Hill et al.

CANNABIS AND CANNABINOID RESEARCH (2017)

Article Substance Abuse

The dose effects of short-term dronabinol (oral THC) maintenance in daily cannabis users

Ryan Vandrey et al.

DRUG AND ALCOHOL DEPENDENCE (2013)

Article Clinical Neurology

MUltiple Sclerosis and Extract of Cannabis: results of the MUSEC trial

John Peter Zajicek et al.

JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY (2012)

Review Biology

The placebo response in clinical trials: more questions than answers

Paul Enck et al.

PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES (2011)

Article Computer Science, Interdisciplinary Applications

Research electronic data capture (REDCap)-A metadata-driven methodology and workflow process for providing translational research informatics support

Paul A. Harris et al.

JOURNAL OF BIOMEDICAL INFORMATICS (2009)

Article Pharmacology & Pharmacy

Control of spasticity in a multiple sclerosis model is mediated by CB1, not CB2, cannabinoid receptors

G. Pryce et al.

BRITISH JOURNAL OF PHARMACOLOGY (2007)

Review Biochemistry & Molecular Biology

Human cannabinoid pharmacokinetics

Marilyn A. Huestis

CHEMISTRY & BIODIVERSITY (2007)

Review Pharmacology & Pharmacy

Pharmacokinetics and pharmacodynamics of cannabinoids

F Grotenhermen

CLINICAL PHARMACOKINETICS (2003)