☆ 4.6 Review

Molecular Biomarkers for Predicting Cancer Patient Radiosensitivity and Radiotoxicity in Clinical Practice

APPLIED SCIENCES-BASEL (2023)

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Nonangiogenic Function of VEGF and Enhanced Radiosensitivity of HeLa Cells by Inhibition of VEGF Expression

Xiaokang Hu et al.

ONCOLOGY RESEARCH (2012)

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Blockade of TGF-β Signaling by the TGFβR-I Kinase Inhibitor LY2109761 Enhances Radiation Response and Prolongs Survival in Glioblastoma

Mengxian Zhang et al.

CANCER RESEARCH (2011)

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TGFβ1 Inhibition Increases the Radiosensitivity of Breast Cancer Cells In Vitro and Promotes Tumor Control by Radiation In Vivo

Fanny Bouquet et al.

CLINICAL CANCER RESEARCH (2011)

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Review Pharmacology & Pharmacy

Drug transporters of platinum-based anticancer agents and their clinical significance

Herman Burger et al.

DRUG RESISTANCE UPDATES (2011)

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Article Oncology

Prolonged expression of the γ-H2AX DNA repair biomarker correlates with excess acute and chronic toxicity from radiotherapy treatment

Emma C. Bourton et al.

INTERNATIONAL JOURNAL OF CANCER (2011)

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Different radiosensitivity of CD4(+)CD25(+) regulatory T cells and effector T cells to low dose gamma irradiation in vitro

Mengde Cao et al.

INTERNATIONAL JOURNAL OF RADIATION BIOLOGY (2011)

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Article Oncology

THE IMPACT OF INDIVIDUAL IN VIVO REPAIR OF DNA DOUBLE-STRAND BREAKS ON ORAL MUCOSITIS IN ADJUVANT RADIOTHERAPY OF HEAD-AND-NECK CANCER

Jochen Fleckenstein et al.

INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS (2011)

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Review Cell Biology

The MRE11 complex: starting from the ends

Travis H. Stracker et al.

NATURE REVIEWS MOLECULAR CELL BIOLOGY (2011)

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Article Oncology

Chromosomal radiosensitivity and acute radiation side effects after radiotherapy in tumour patients - a follow-up study

Reinhard Huber et al.

RADIATION ONCOLOGY (2011)

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Article Oncology

A standardized G2-assay for the prediction of individual radiosensitivity

Gabriel E. Pantelias et al.

RADIOTHERAPY AND ONCOLOGY (2011)

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Residual DNA and chromosomal damage in ex vivo irradiated blood lymphocytes correlated with late normal tissue response to breast radiotherapy

Melvin Lee Kiang Chua et al.

RADIOTHERAPY AND ONCOLOGY (2011)

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H2AX phosphorylation screen of cells from radiosensitive cancer patients reveals a novel DNA double-strand break repair cellular phenotype

R. S. Vasireddy et al.

BRITISH JOURNAL OF CANCER (2010)

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Blockade of Tumor Necrosis Factor α Signaling in Tumor-Associated Macrophages as a Radiosensitizing Strategy

Yuru Meng et al.

CANCER RESEARCH (2010)

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Review Oncology

γH2AX: a sensitive molecular marker of DNA damage and repair

L-J Mah et al.

LEUKEMIA (2010)

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Targeting the TGF-beta 1 Pathway to Prevent Normal Tissue Injury After Cancer Therapy

Mitchell S. Anscher

ONCOLOGIST (2010)

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The European strategy on low dose risk research and the role of radiation quality according to the recommendations of the ad hoc High Level and Expert Group (HLEG)

Mauro Belli et al.

RADIATION AND ENVIRONMENTAL BIOPHYSICS (2010)

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Radiation induced apoptosis and initial DNA damage are inversely related in locally advanced breast cancer patients

Beatriz Pinar et al.

RADIATION ONCOLOGY (2010)

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Inflammatory Biomarkers and Fatigue during Radiation Therapy for Breast and Prostate Cancer

Jullienne E. Bower et al.

CLINICAL CANCER RESEARCH (2009)

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Genetic variations in DNA repair genes, radiosensitivity to cancer and susceptibility to acute tissue reactions in radiotherapy-treated cancer patients

Dimitry A. Chistiakov et al.

ACTA ONCOLOGICA (2008)

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Tumor necrosis factor and cancer, buddies or foes?

Xia Wang et al.

ACTA PHARMACOLOGICA SINICA (2008)

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An oncogene-induced DNA damage model for cancer development

Thanos D. Halazonetis et al.

SCIENCE (2008)

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Article Biochemistry & Molecular Biology

Role of TGF-β1 and nitric oxide in the bystander response of irradiated glioma cells

C. Shao et al.

ONCOGENE (2008)

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OPINION γH2AX and cancer

William M. Bonner et al.

NATURE REVIEWS CANCER (2008)

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Novel NBS1 heterozygous germ line mutation causing MRE11-binding domain loss predisposes to common types of cancer

Hiromichi Ebi et al.

CANCER RESEARCH (2007)

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Inhibition of TGF-β with neutralizing antibodies prevents radiation-induced acceleration of metastatic cancer progression

Swati Biswas et al.

JOURNAL OF CLINICAL INVESTIGATION (2007)

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Intact Mre11/Rad50/Nbs1 complex predicts good response to radiotherapy in early breast cancer

Karin Soderlund et al.

INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS (2007)

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Review Cell Biology

ATM activation and DNA damage response

Martin F. Lavin et al.

CELL CYCLE (2007)

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Kinetics and dose-response of residual 53BP1/gamma-H2AX foci: Co-localization, relationship with DSB repair and clonogenic survival

E. Markova et al.

INTERNATIONAL JOURNAL OF RADIATION BIOLOGY (2007)

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Amifostine: The first selective-target and broad-spectrum radioprotector

John R. Kouvaris et al.

ONCOLOGIST (2007)

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Apoptosis: A review of programmed cell death

Susan Elmore

TOXICOLOGIC PATHOLOGY (2007)

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Enhanced chromosomal radiosensitivity in peripheral blood lymphocytes of larynx cancer patients

Halina Lisowska et al.

INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS (2006)

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Article Biochemistry & Molecular Biology

Defective Mre11-dependent activation of Chk2 by ataxia telangiectasia mutated in colorectal carcinoma cells in response to replication-dependent DNA double strand breaks

Haruyuki Takemura et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2006)

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Proteomics analysis of apoptosis-regulating proteins in tissues with different radiosensitivity

Jeung Hee An et al.

JOURNAL OF RADIATION RESEARCH (2006)

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The cyclin-dependent kinase 2 inhibitor down-regulates interleukin-1β-mediated induction of cyclooxygenase-2 expression in human lung carcinoma cells

P Mukhopadhyay et al.

CANCER RESEARCH (2006)

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Article Biochemical Research Methods

Clonogenic assay of cells in vitro

Nicolaas A. P. Franken et al.

NATURE PROTOCOLS (2006)

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Cell death mechanisms associated with G2 radiosensitivity in patients with prostate cancer and benign prostatic hyperplasia

O Howe et al.

RADIATION RESEARCH (2005)

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Solid tumor risks after high doses of ionizing radiation

RK Sachs et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2005)

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Elevated G2 chromosomal radiosensitivity in Irish breast cancer patients: a comparison with other studies

OL Howe et al.

INTERNATIONAL JOURNAL OF RADIATION BIOLOGY (2005)

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The prognostic significance of plasma interleukin-6 levels in patients with metastatic hormone-refractory prostate cancer: Results from cancer and leukemia group B 9480

DJ George et al.

CLINICAL CANCER RESEARCH (2005)

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Review Pharmacology & Pharmacy

Children as a sensitive subpopulation for the risk assessment process

RJ Preston

TOXICOLOGY AND APPLIED PHARMACOLOGY (2004)

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Article Biotechnology & Applied Microbiology

Chromosomal radiosensitivity:: a study of the chromosomal G2 assay in human blood lymphocytes indicating significant inter-individual variability

V Smart et al.

MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS (2003)

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CTCAE v3.0: Development of a comprehensive grading system for the adverse effects of cancer treatment

A Trotti et al.

SEMINARS IN RADIATION ONCOLOGY (2003)

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Anti-interleukin-6 receptor antibody therapy reduces vascular endothelial growth factor production in rheumatoid arthritis

H Nakahara et al.

ARTHRITIS AND RHEUMATISM (2003)

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The biology of VEGF and its receptors

N Ferrara et al.

NATURE MEDICINE (2003)

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Mucositis incidence, severity and associated outcomes in patients with head and neck cancer receiving radiotherapy with or without chemotherapy: a systematic literature review

A Trotti et al.

RADIOTHERAPY AND ONCOLOGY (2003)

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Inflammation and cancer

LM Coussens et al.

NATURE (2002)

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Interleukin-1β inhibits expression of p21(WAF1/CIP1) and p27(KIP1) and enhances proliferation in response to platelet-derived growth factor-BB in smooth muscle cells

TJ Nathe et al.

ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY (2002)

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Induction and disappearance of G2 chromatid breaks in lymphocytes after low doses of low-LET γ-rays and high-LET fast neutrons

A Vral et al.

INTERNATIONAL JOURNAL OF RADIATION BIOLOGY (2002)

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Article Biochemistry & Molecular Biology

Histone H2AX is phosphorylated in an ATR-dependent manner in response to replicational stress.

IM Ward et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2001)

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Plasma levels of interleukin-6 and its soluble receptor are associated with prostate cancer progression and metastasis

SF Shariat et al.

UROLOGY (2001)

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Endothelial apoptosis as the primary lesion initiating intestinal radiation damage in mice

F Paris et al.

SCIENCE (2001)

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Vascular endothelial cell growth factor (VEGF) induces cyclooxygenase (COX)-dependent proliferation of endothelial cells (EC) via the VEGF-2 receptor

JF Murphy et al.

FASEB JOURNAL (2001)

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Article Biochemistry & Molecular Biology

Interleukin-1β induces cyclooxygenase-2 and prostaglandin E2 synthesis in human neuroblastoma cells:: Involvement of p38 mitogen-activated protein kinase and nuclear factor-κB

BL Fiebich et al.

JOURNAL OF NEUROCHEMISTRY (2000)

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Article Biochemistry & Molecular Biology

A critical role for histone H2AX in recruitment of repair factors to nuclear foci after DNA damage

TT Paull et al.

CURRENT BIOLOGY (2000)

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