Novel-miR-81 Promotes the Chondrocytes Differentiation of Bone Marrow Mesenchymal Stem Cells Through Inhibiting Rac2 Expression

Article Cell & Tissue Engineering

Maclurin Promotes the Chondrogenic Differentiation of Bone Marrow Mesenchymal Stem Cells by Regulating miR-203a-3p/Smad1

Jiechen Kong et al.

Summary: Mulberry root extract promotes chondrogenic differentiation of bone marrow mesenchymal stem cells (BMSCs) by regulating miR-203a-3p/Smad1 pathway, providing a new strategy for osteoarthritis therapy.

CELLULAR REPROGRAMMING (2022)

Add to Collection

Article Biochemistry & Molecular Biology

Effect Of XBP1 Deficiency In Cartilage On The Regulatory Network Of LncRNA/circRNA-miRNA-mRNA

Xiaoli Li et al.

Summary: XBP1 deficiency in cartilage affects the function of cartilage and other tissues, as well as associated diseases. The study establishes lncRNA-miRNA-mRNA and circRNA-miRNA-mRNA networks, providing potential biomarkers and mechanisms for the diagnosis and treatment of cartilage and other related diseases.

INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES (2022)

Add to Collection

Article Chemistry, Medicinal

Effects of Cartilage Progenitor Cells, Bone Marrow Mesenchymal Stem Cells and Chondrocytes on Cartilage Repair as Seed Cells: An in vitro Study

Jiaxiang Gu et al.

Summary: In this study, the effects of cartilage progenitor cells (CPCs), bone marrow mesenchymal stem cells (BMSCs), and chondrocytes (CCs) on cartilage repair were investigated. The results showed that CPCs had higher proliferation ability compared to CCs and BMSCs. Moreover, CPCs seeded in agarose gel exhibited significantly higher levels of collagen, glycosaminoglycan, DNA content, and chondrocyte-related gene expression. Integration strength in the CPCs seeded gel was also higher than the other two gels. These findings suggest that CPCs have advantages over CCs and BMSCs as seed cells in tissue engineering for cartilage repair.

DRUG DESIGN DEVELOPMENT AND THERAPY (2022)

Add to Collection

Review Pharmacology & Pharmacy

Effects of BMSC-Derived EVs on Bone Metabolism

Xuchang Zhou et al.

Summary: Extracellular vesicles (EVs) are small membrane vesicles that can be secreted by most cells. EVs, especially BMSC-EVs, have therapeutic effects such as tissue repair, inhibition of macrophage polarization, and promotion of angiogenesis. BMSC-EVs also serve as efficient nanocarriers for drug delivery with advantages such as low immunogenicity, no ethical controversy, good stability, and easy storage.

PHARMACEUTICS (2022)

Add to Collection

Article Cell & Tissue Engineering

Curcumin Supplementation Enhances Bone Marrow Mesenchymal Stem Cells to Promote the Anabolism of Articular Chondrocytes and Cartilage Repair

Rui Zhang et al.

Summary: This study investigated the effects of curcumin on the therapeutic effects of BMSCs in osteoarthritis, finding that curcumin supplementation enhanced the proliferation, migration, and anabolic gene expression of articular chondrocytes when cocultured with BMSCs, leading to improved cartilage repair and slowed OA progression.

CELL TRANSPLANTATION (2021)

Add to Collection

Article Materials Science, Biomaterials