Spray-dried calcium phosphate-gelatin composites and their behavior in simulated body fluid with the presence of cross-linking agent

Calcium phosphates are a major focus in the biomedical field. However, among the various types, calcium pyrophosphate dihydrate and their integration with polymers are not investigated widely in the literature. This study aims to produce calcium phosphate including calcium pyrophosphate dihydrate and hydroxyapatite integrated with gelatin by a novel method using a spray dryer. The bioactivity of these samples in simulated body fluid is examined to assess their potential usage in the biomedical area. Spray-dried samples are analyzed by Fourier transform infrared (FTIR), X-ray diffractometer (XRD), and scanning electron microscopy (SEM). Regarding the samples soaked in SBF, FTIR and SEM analyses are conducted. Additionally, the absorption and degradation of pellets in simulated body fluid, as well as the pH change, are determined. It is concluded that successful composites are synthesized and have potential applications in the biomedical field.

Automated summary

This study synthesized calcium phosphate samples, including calcium pyrophosphate dihydrate and hydroxyapatite, using a novel method with a spray dryer. The bioactivity of these samples in simulated body fluid was tested to evaluate their potential applications in the biomedical field.