Journal
ORAL SURGERY ORAL MEDICINE ORAL PATHOLOGY ORAL RADIOLOGY
Volume 122, Issue 6, Pages 743-+Publisher
ELSEVIER SCIENCE INC
DOI: 10.1016/j.oooo.2016.07.022
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Funding
- University of Florida institutional funds, Andrew J. Semesco Foundation, Ocala, Florida, USA
- UMM ALQURA University, Saudi Arabia
- Saudi Arabian Cultural Mission
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Objective. Malignant transformation of oral premalignant lesions is the key process in the progression to oral squamous cell carcinoma (OSCC). Previously, we identified miR-7 and miR-21 as candidate oncogenes and miR-375 and miR-494 as candidate tumor suppressors in OSCC. We aim to evaluate these microRNAs as biomarkers of malignant transformation in oral premalignant lesions. Study Design. Formalin-fixed, paraffin-embedded samples from progressive premalignant lesions and paired sequential OSCC tumors at the same site were obtained from same patients (n-31). Total RNA was extracted and analyzed for microRNA levels using real-time polymerase chain reaction. Results. MiR-375 expression in progressive lesions was clearly lower than in nonprogressive control lesions (average eightfold difference, P = .0004). Furthermore, the expression of miR-375 decreased significantly after the progression from premalignant lesion to OSCC (P < .0001). Receiver operating characteristic curve analysis revealed that miR-375 was able to differentiate between progressive and nonprogressive premalignant lesions (P < .0001). Conclusions. MiR-375 downregulation in oral premalignant lesions is associated with a higher risk of malignant transformation.
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