4.3 Article

The impact of chromatin on double-strand break repair: Imaging tools and discoveries

Related references

Note: Only part of the references are listed.
Article Biochemistry & Molecular Biology

Centromeres as universal hotspots of DNA breakage, driving RAD51-mediated recombination during quiescence

Xanita Saayman et al.

Summary: Centromeres, which are essential for chromosome segregation, are rapidly evolving genome elements. This study reveals that human centromeres naturally contain a high number of DNA breaks within functionally active regions. These breaks are induced during both active cellular proliferation and quiescence, and are resolved by the RAD51 recombinase, contributing to the specification of functional centromeres. The findings suggest that the innate fragility of centromeres may have played a role in their evolution and could contribute to human disease.

MOLECULAR CELL (2023)

Article Biochemistry & Molecular Biology

Multiscale reorganization of the genome following DNA damage facilitates chromosome translocations via nuclear actin polymerization

Jennifer Zagelbaum et al.

Summary: Research shows that nuclear actin movements are involved in clustering DNA double-strand breaks (DSBs) for homology-directed repair. This study explores the three-dimensional reorganization of the genome after DNA damage and examines the role of the nuclear WASP-ARP2/3-actin pathway in chromatin topology changes during pathological repair. The results indicate that DNA damage induces genome-wide chromatin compartment flips mediated by ARP2/3, leading to enrichment of open, A compartments. Additionally, DSB interactions promote aberrant actin-dependent rearrangements within and between chromosomes. This work demonstrates that nuclear actin assembly orchestrates DSB clustering for repair while also impacting genome architecture and translocation frequency.

NATURE STRUCTURAL & MOLECULAR BIOLOGY (2023)

Article Multidisciplinary Sciences

The Smc5/6 complex is a DNA loop-extruding motor

Biswajit Pradhan et al.

Summary: Using single-molecule imaging, it was found that Smc5/6 protein complex forms DNA loops by extrusion. ATP hydrolysis allows Smc5/6 to symmetrically reel DNA into loops at a rate of one kilobase pair per second. The subunits Nse5/6 act as negative regulators, inhibiting loop-extrusion initiation by hindering Smc5/6 dimerization.

NATURE (2023)

Article Multidisciplinary Sciences

Pol? is phosphorylated by PLK1 to repair double-strand breaks in mitosis

Camille Gelot et al.

Summary: In mitosis, genome integrity is maintained by DNA polymerase theta-dependent repair of DNA double-strand breaks, which is regulated by Polo-like kinase 1 activity.

NATURE (2023)

Review Cell Biology

Principles and functions of pericentromeric satellite DNA clustering into chromocenters

Franziska Brandle et al.

Summary: In this paper, the literature on pericentromeric satellite DNA is reviewed and its organization and functions across eukaryotic species are discussed. The focus is on chromocenters, DNA-dense nuclear foci containing clustered pericentromeric satellite DNA repeats. The roles of epigenetic modifications, satellite DNA transcripts, and sequence-specific satellite DNA-binding in chromocenter formation are examined. Additionally, the emerging functions of chromocenters in genome encapsulation, maintaining cell fate, and speciation are reviewed, with an emphasis on the impact of rapid divergence of satellite DNA repeats on reproductive isolation between closely related species.

SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY (2022)

Article Biochemistry & Molecular Biology

Heterochromatic repeat clustering imposes a physical barrier on homologous recombination to prevent chromosomal translocations

Ioanna Mitrentsi et al.

Summary: In this study, the spatial recruitment of HR factors upon DNA breaks was compared between human and mouse pericentromeric heterochromatin. It was found that mouse pericentromeric heterochromatin repeat clustering creates a physical barrier that requires multiple layers of de-compaction for access to repair. These findings highlight the importance of the 3D organization of heterochromatin in the spatial activation of DNA repair pathways.

MOLECULAR CELL (2022)

Article Multidisciplinary Sciences

Complete genomic and epigenetic maps of human centromeres

Nicolas Altemose et al.

Summary: Current human genome assemblies have neglected repetitive sequences near centromeres, hindering our understanding of their organization and evolution. A new approach has allowed researchers to comprehensively study these sequences, revealing their structural rearrangements and variations.

SCIENCE (2022)

Article Genetics & Heredity

An Expanding Toolkit for Heterochromatin Repair Studies

Chetan C. Rawal et al.

Summary: By reviewing current tools and methods, we gain insights into the process and techniques of double-strand break repair in pericentromeric regions. The technologies developed for euchromatin repair studies can be employed to investigate responses in heterochromatin. These studies contribute to a better understanding of genome stability mechanisms.

GENES (2022)

Article Cell Biology

Imaging the Response to DNA Damage in Heterochromatin Domains

Audrey Chansard et al.

Summary: The organization of chromatin has a significant impact on DNA damage repair. Heterochromatin, through transcriptional silencing, plays a vital role in maintaining genome integrity and cellular homeostasis. Understanding the effect of heterochromatin on the DNA damage response is critical, and this study presents two laser micro-irradiation-based methods for imaging the DDR in heterochromatin domains in mammalian cells.

FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY (2022)

Article Multidisciplinary Sciences

Assignment of structural transitions during mechanical unwrapping of nucleosomes and their disassembly products

Cesar Diaz-Celis et al.

Summary: DNA unwrapping and disassembly of nucleosomes play a crucial role in genomic access and transcription regulation. This study, using high-resolution optical tweezers and single-molecule FRET detection, reveals the asymmetry in nucleosome unwrapping and identifies the DNA segments involved in the process. It also suggests the stochastic disassembly of nucleosomes into hexasomes and tetrasomes.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2022)

Article Multidisciplinary Sciences

DNA damage reduces heterogeneity and coherence of chromatin motions br

Maelle Locatelli et al.

Summary: Chromatin motions are regulated by and may regulate genome functions, particularly in response to DNA damage. In mammalian cells, there is a high level of spatial heterogeneity in the motions of chromatin microdomains. DNA damage reduces heterogeneity and causes spatially defined shifts in chromatin motions.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2022)

Article Genetics & Heredity

From fluorescent foci to sequence: Illuminating DNA double strand break repair by high-throughput sequencing technologies

Xabier Vergara et al.

Summary: The traditional methods for studying DNA repair rely on fluorescence read-outs, while high throughput sequencing (HTS) has created new opportunities to understand the mechanisms behind double-strand break (DSB) repair.

DNA REPAIR (2022)

Article Multidisciplinary Sciences

Search and processing of Holliday junctions within long DNA by junction-resolving enzymes

Artur P. Kaczmarczyk et al.

Summary: This study captures the entire reaction trajectory of a nuclease targeting and resolving a DNA junction at single-molecule level. The results show that the enzyme first binds remotely to dsDNA and undergoes 1D diffusion before cleaving the junction upon encountering it.

NATURE COMMUNICATIONS (2022)

Article Biology

Global chromatin mobility induced by a DSB is dictated by chromosomal conformation and defines the HR outcome

Fabiola Garcia Fernandez et al.

Summary: The repair of DNA double-strand breaks is crucial for genome integrity, and global chromatin mobility plays a vital role in homologous recombination process, with its effects varying depending on the position of the DSB, leading to accelerated repair kinetics and being essential for repair away from the centromere.

ELIFE (2022)

Article Biochemistry & Molecular Biology

Single-molecule analysis reveals cooperative stimulation of Rad51 filament nucleation and growth by mediator proteins

Ondrej Belan et al.

Summary: Homologous recombination (HR) is a crucial DNA repair mechanism that is often disrupted in cancer, with RAD51 playing a key role in this process. Employing single-molecule imaging, the study investigated the mechanism of RAD-51 nucleation and filament growth in the presence of recombination mediators BRC-2 and RAD-51 paralogs RFS-1/RIP-1. The findings revealed that BRC-2 initiates RAD-51 nucleation on RPA-coated DNA, while RFS-1/RIP-1 acts as a chaperone to promote filament growth by dynamically engaging with filament ends.

MOLECULAR CELL (2021)

Article Multidisciplinary Sciences

Activation of homologous recombination in G1 preserves centromeric integrity

Duygu Yilmaz et al.

Summary: Centromeric integrity is crucial for proper chromosome segregation during cell division. DNA breaks at centromeres in G1 recruit homologous recombination machinery, involving specific histone variants, chaperones, and histone modifications. Inhibiting homologous recombination in G1 leads to centromeric instability and chromosomal translocations, highlighting the importance of licensing homologous recombination at centromeric breaks throughout the cell cycle.

NATURE (2021)

Article Multidisciplinary Sciences

CENP-A chromatin prevents replication stress at centromeres to avoid structural aneuploidy

Simona Giunta et al.

Summary: The study demonstrates the importance of the centromere-specific histone H3 variant CENP-A in safeguarding DNA replication of alpha-satellite repeats to prevent structural aneuploidy during S phase, providing insights into how specialized centromeric chromatin maintains the integrity of transcribed noncoding repetitive DNA.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2021)

Review Cell Biology

Chromatin mobility and relocation in DNA repair

Noa Lamm et al.

Summary: This study focuses on the role of nuclear-specific filamentous actin in mobilizing damaged chromatin in response to DNA double-strand breaks and replication stress, as well as the importance of nuclear pore complexes and promyelocytic leukemia-nuclear bodies as specialized platforms for homology-directed repair. The literature suggests an emerging model where specific types of DNA lesions are subjected to nuclear-derived forces that promote interaction with repair hubs to facilitate specialized repair reactions.

TRENDS IN CELL BIOLOGY (2021)

Article Biochemistry & Molecular Biology

Impact of chromatin context on Cas9-induced DNA double-strand break repair pathway balance

Ruben Schep et al.

Summary: Through systematically analyzing the impact of chromatin context on three DNA double-strand break repair pathways, it was found that non-homologous end-joining is more common in euchromatin, while microhomology-mediated end-joining is more active in specific heterochromatin contexts. Additionally, single-stranded template repair competes strongly with other repair pathways and is moderately linked to chromatin context.

MOLECULAR CELL (2021)

Article Multidisciplinary Sciences

Imaging the response to DNA damage in heterochromatin domains reveals core principles of heterochromatin maintenance

Anna Fortuny et al.

Summary: Heterochromatin is a critical chromatin compartment that plays a key role in genome stability and cell fate transitions. This study reveals how heterochromatin features are preserved following a genotoxic stress challenge by tracking the heterochromatin response to UV damage in real time.

NATURE COMMUNICATIONS (2021)

Review Genetics & Heredity

The Sound of Silence: How Silenced Chromatin Orchestrates the Repair of Double-Strand Breaks

Apfrida Kendek et al.

Summary: The eukaryotic nucleus is constantly exposed to sources causing DNA breaks, requiring dedicated nuclear machinery for faithful repair. DNA is packaged into various chromatin domains with specific molecular properties regulating gene expression and nuclear structure maintenance. Different chromatin environments demand tailored responses to DNA damage.

GENES (2021)

Article Multidisciplinary Sciences

Treacle controls the nucleolar response to rDNA breaks via TOPBP1 recruitment and ATR activation

Clemence Mooser et al.

NATURE COMMUNICATIONS (2020)

Editorial Material Cell Biology

Nucleolar Organization and Functions in Health and Disease

Ursula Stochaj et al.

CELLS (2020)

Article Multidisciplinary Sciences

Oncometabolites suppress DNA repair by disrupting local chromatin signalling

Parker L. Sulkowski et al.

NATURE (2020)

Article Biochemistry & Molecular Biology

Recent advances in the nucleolar responses to DNA double-strand breaks

Lea Milling Korsholm et al.

NUCLEIC ACIDS RESEARCH (2020)

Article Multidisciplinary Sciences

Single-molecule and in silico dissection of the interaction between Polycomb repressive complex 2 and chromatin

Rachel Leicher et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2020)

Review Biochemistry & Molecular Biology

Studying DNA Double-Strand Break Repair: An Ever-Growing Toolbox

Alexandra C. Vitor et al.

FRONTIERS IN MOLECULAR BIOSCIENCES (2020)

Review Biotechnology & Applied Microbiology

Histone methylation and the DNA damage response

Fade Gong et al.

MUTATION RESEARCH-REVIEWS IN MUTATION RESEARCH (2019)

Article Cell Biology

H4K20meO recognition by BRCA1-BARD1 directs homologous recombination to sister chromatids

Kyosuke Nakamura et al.

NATURE CELL BIOLOGY (2019)

Review Genetics & Heredity

A Snapshot on the Cis Chromatin Response to DNA Double-Strand Breaks

Thomas Clouaire et al.

TRENDS IN GENETICS (2019)

Article Multidisciplinary Sciences

Reversible histone glycation is associated with disease-related changes in chromatin architecture

Qingfei Zheng et al.

NATURE COMMUNICATIONS (2019)

Review Biochemical Research Methods

Molecular Tools to Generate Reactive Oxygen Species in Biological Systems

Ying Xiong et al.

BIOCONJUGATE CHEMISTRY (2019)

Article Biochemistry & Molecular Biology

Spatial Chromosome Folding and Active Transcription Drive DNA Fragility and Formation of Oncogenic MLL Translocations

Henrike Johanna Gothe et al.

MOLECULAR CELL (2019)

Review Cell Biology

DNA double-strand break repair-pathway choice in somatic mammalian cells

Ralph Scully et al.

NATURE REVIEWS MOLECULAR CELL BIOLOGY (2019)

Review Cell Biology

Nuclear actin filaments in DNA repair dynamics

Christopher Patrick Caridi et al.

NATURE CELL BIOLOGY (2019)

Review Cell Biology

Ten principles of heterochromatin formation and function

Robin C. Allshire et al.

NATURE REVIEWS MOLECULAR CELL BIOLOGY (2018)

Review Cell Biology

Dynamic regulation of nucleolar architecture

Attila Nemeth et al.

CURRENT OPINION IN CELL BIOLOGY (2018)

Article Biochemistry & Molecular Biology

Protein Dynamics in Complex DNA Lesions

Radoslav Aleksandrov et al.

MOLECULAR CELL (2018)

Article Biochemistry & Molecular Biology

Kinetics and Fidelity of the Repair of Cas9-Induced Double-Strand DNA Breaks

Eva K. Brinkman et al.

MOLECULAR CELL (2018)

Review Biochemistry & Molecular Biology

Nucleolus as an emerging hub in maintenance of genome stability and cancer pathogenesis

Mikael S. Lindstrom et al.

ONCOGENE (2018)

Review Cell Biology

Heterochromatin: Guardian of the Genome

Aniek Janssen et al.

ANNUAL REVIEW OF CELL AND DEVELOPMENTAL BIOLOGY, VOL 34 (2018)

Article Multidisciplinary Sciences

Nuclear F-actin and myosins drive relocalization of heterochromatic breaks

Christopher P. Caridi et al.

NATURE (2018)

Article Multidisciplinary Sciences

Nuclear ARP2/3 drives DNA break clustering for homology-directed repair

Benjamin R. Schrank et al.

NATURE (2018)

Review Genetics & Heredity

The Smc5/6 Complex: New and Old Functions of the Enigmatic Long-Distance Relative

Luis Aragon

ANNUAL REVIEW OF GENETICS, VOL 52 (2018)

Article Genetics & Heredity

DNA replication and repair kinetics of Alu, LINE-1 and satellite III genomic repetitive elements

Francesco Natale et al.

EPIGENETICS & CHROMATIN (2018)

Article Biochemistry & Molecular Biology

Heterochromatin delays CRISPR-Cas9 mutagenesis but does not influence the outcome of mutagenic DNA repair

Eirini M. Kallimasioti-Pazi et al.

PLOS BIOLOGY (2018)

Article Multidisciplinary Sciences

Variable chromatin structure revealed by in situ spatially correlated DNA cleavage mapping

Viviana I. Risca et al.

NATURE (2017)

Review Environmental Sciences

Mechanisms of DNA Damage, Repair, and Mutagenesis

Nimrat Chatterjee et al.

ENVIRONMENTAL AND MOLECULAR MUTAGENESIS (2017)

Article Multidisciplinary Sciences

Phase separation drives heterochromatin domain formation

Amy R. Strom et al.

NATURE (2017)

Article Multidisciplinary Sciences

Liquid droplet formation by HP1α suggests a role for phase separation in heterochromatin

Adam G. Larson et al.

NATURE (2017)

Article Biochemistry & Molecular Biology

Genome-wide mapping of long-range contacts unveils clustering of DNA double-strand breaks at damaged active genes

Francois Aymard et al.

NATURE STRUCTURAL & MOLECULAR BIOLOGY (2017)

Article Multidisciplinary Sciences

Identification of the elementary structural units of the DNA damage response

Francesco Natale et al.

NATURE COMMUNICATIONS (2017)

Article Biochemistry & Molecular Biology

Genome-wide mapping of long-range contacts unveils clustering of DNA double-strand breaks at damaged active genes

Francois Aymard et al.

NATURE STRUCTURAL & MOLECULAR BIOLOGY (2017)

Review Plant Sciences

Impact of transposable elements on polyploid plant genomes

Carlos M. Vicient et al.

ANNALS OF BOTANY (2017)

Article Biochemistry & Molecular Biology

Genome Organization Drives Chromosome Fragility

Andres Canela et al.

Review Biochemistry & Molecular Biology

Linking replication stress with heterochromatin formation

Ivaylo Nikolov et al.

CHROMOSOMA (2016)

Review Cell Biology

The molecular basis for centromere identity and function

Kara L. McKinley et al.

NATURE REVIEWS MOLECULAR CELL BIOLOGY (2016)

Article Biochemistry & Molecular Biology

DNA Breaks and End Resection Measured Genome-wide by End Sequencing

Andres Canela et al.

MOLECULAR CELL (2016)

Article Biochemistry & Molecular Biology

Temporal and Spatial Uncoupling of DNA Double Strand Break Repair Pathways within Mammalian Heterochromatin

Katerina Tsouroula et al.

MOLECULAR CELL (2016)

Article Cell Biology

SCAI promotes DNA double-strand break repair in distinct chromosomal contexts

Rebecca Kring Hansen et al.

NATURE CELL BIOLOGY (2016)

Review Genetics & Heredity

The molecular hallmarks of epigenetic control

C. David Allis et al.

NATURE REVIEWS GENETICS (2016)

Article Cell Biology

Breaks in the 45S rDNA Lead to Recombination-Mediated Loss of Repeats

Daniel O. Warmerdam et al.

CELL REPORTS (2016)

Review Biotechnology & Applied Microbiology

Relocalization of DNA lesions to the nuclear pore complex

Catherine H. Freudenreich et al.

FEMS YEAST RESEARCH (2016)

Review Biochemistry & Molecular Biology

Determinants of mammalian nucleolar architecture

Katherine I. Farley et al.

CHROMOSOMA (2015)

Article Cell Biology

Repeat DNA in genome organization and stability

Jan Padeken et al.

CURRENT OPINION IN GENETICS & DEVELOPMENT (2015)

Article Multidisciplinary Sciences

Cell-of-origin chromatin organization shapes the mutational landscape of cancer

Paz Polak et al.

NATURE (2015)

Review Environmental Sciences

Recognition and Repair of Chemically Heterogeneous Structures at DNA Ends

Sara N. Andres et al.

ENVIRONMENTAL AND MOLECULAR MUTAGENESIS (2015)

Review Biochemistry & Molecular Biology

Ionizing Radiation-Induced DNA Damage, Response, and Repair

Wil L. Santivasi et al.

ANTIOXIDANTS & REDOX SIGNALING (2014)

Article Cell Biology

Nuclear position dictates DNA repair pathway choice

Charlene Lemaitre et al.

GENES & DEVELOPMENT (2014)

Article Cell Biology

The NBS1-Treacle complex controls ribosomal RNA transcription in response to DNA damage

Dorthe H. Larsen et al.

NATURE CELL BIOLOGY (2014)

Article Biochemistry & Molecular Biology

Transcriptionally active chromatin recruits homologous recombination at DNA double-strand breaks

Francois Aymard et al.

NATURE STRUCTURAL & MOLECULAR BIOLOGY (2014)

Article Cell Biology

Sources of DNA Double-Strand Breaks and Models of Recombinational DNA Repair

Anuja Mehta et al.

COLD SPRING HARBOR PERSPECTIVES IN BIOLOGY (2014)

Review Biochemistry & Molecular Biology

Chromatin Remodeling at DNA Double-Strand Breaks

Brendan D. Price et al.

Review Biotechnology & Applied Microbiology

Mammalian DNA repair: HATs and HDACs make their mark through histone acetylation

Fade Gong et al.

MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS (2013)

Article Biotechnology & Applied Microbiology

CAS9 transcriptional activators for target specificity screening and paired nickases for cooperative genome engineering

Prashant Mali et al.

NATURE BIOTECHNOLOGY (2013)

Article Cell Biology

Repair of Double-Strand Breaks by End Joining

Kishore K. Chiruvella et al.

COLD SPRING HARBOR PERSPECTIVES IN BIOLOGY (2013)

Article Cell Biology

DNA Damage Sensing by the ATM and ATR Kinases

Alexandre Marechal et al.

COLD SPRING HARBOR PERSPECTIVES IN BIOLOGY (2013)

Article Multidisciplinary Sciences

Genetically encoded system to track histone modification in vivo

Yuko Sato et al.

SCIENTIFIC REPORTS (2013)

Article Biochemistry & Molecular Biology

Histone marks: repairing DNA breaks within the context of chromatin

Kyle M. Miller et al.

BIOCHEMICAL SOCIETY TRANSACTIONS (2012)

Article Multidisciplinary Sciences

Chromatin organization is a major influence on regional mutation rates in human cancer cells

Benjamin Schuster-Boeckler et al.

NATURE (2012)

Article Biochemistry & Molecular Biology

Tracking epigenetic histone modifications in single cells using Fab-based live endogenous modification labeling

Yoko Hayashi-Takanaka et al.

NUCLEIC ACIDS RESEARCH (2011)

Article Multidisciplinary Sciences

Active liquid-like behavior of nucleoli determines their size and shape in Xenopus laevis oocytes

Clifford P. Brangwynne et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2011)

Review Biochemistry & Molecular Biology

Non-B DNA structure-induced genetic instability and evolution

Junhua Zhao et al.

CELLULAR AND MOLECULAR LIFE SCIENCES (2010)

Article Biochemistry & Molecular Biology

High-resolution profiling of γH2AX around DNA double strand breaks in the mammalian genome

Jason S. Iacovoni et al.

EMBO JOURNAL (2010)

Article Cell Biology

Leaping forks at inverted repeats

Dana Branzei et al.

GENES & DEVELOPMENT (2010)

Article Biochemistry & Molecular Biology

Molecular Maps of the Reorganization of Genome-Nuclear Lamina Interactions during Differentiation

Daan Peric-Hupkes et al.

MOLECULAR CELL (2010)

Article Oncology

Human rRNA Gene Clusters Are Recombinational Hotspots in Cancer

Dawn M. Stults et al.

CANCER RESEARCH (2009)

Article Biochemistry & Molecular Biology

ATM and Artemis promote homologous recombination of radiation-induced DNA double-strand breaks in G2

Andrea Beucher et al.

EMBO JOURNAL (2009)

Article Multidisciplinary Sciences

Double-strand DNA breaks recruit the centromeric histone CENP-A

Samantha G. Zeitlin et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2009)

Review Cell Biology

The Epigenetics of rRNA Genes: From Molecular to Chromosome Biology

Brian McStay et al.

ANNUAL REVIEW OF CELL AND DEVELOPMENTAL BIOLOGY (2008)

Article Biochemistry & Molecular Biology

ATM signaling facilitates repair of DNA double-strand breaks associated with heterochromatin

Aaron A. Goodarzi et al.

MOLECULAR CELL (2008)

Article Multidisciplinary Sciences

HP1-β mobilization promotes chromatin changes that initiate the DNA damage response

Nabieh Ayoub et al.

NATURE (2008)

Article Multidisciplinary Sciences

CDK targets Sae2 to control DNA-end resection and homologous recombination

Pablo Huertas et al.

NATURE (2008)

Review Genetics & Heredity

Epigenetic regulation of centromeric chromatin: old dogs, new tricks?

Robin C. Allshire et al.

NATURE REVIEWS GENETICS (2008)

Review Biochemistry & Molecular Biology

gamma-H2AX in recognition and signaling of DNA double-strand breaks in the context of chromatin

Andrea Kinner et al.

NUCLEIC ACIDS RESEARCH (2008)

Article Cell Biology

Activation of multiple DNA repair pathways by subnuclear damage induction methods

Christoffel Dinant et al.

JOURNAL OF CELL SCIENCE (2007)

Article Multidisciplinary Sciences

Sequence finishing and mapping of Drosophila melanogaster heterochromatin

Roger A. Hoskins et al.

SCIENCE (2007)

Article Cell Biology

Roles of ATM and NBS1 in chromatin structure modulation and DNA double-strand break repair

Elijahu Berkovich et al.

NATURE CELL BIOLOGY (2007)

Article Multidisciplinary Sciences

Lamin A-dependent nuclear defects in human aging

P Scaffidi et al.

SCIENCE (2006)

Review Genetics & Heredity

Repeat instability: Mechanisms of dynamic mutations

CE Pearson et al.

NATURE REVIEWS GENETICS (2005)

Article Cell Biology

Targeted mutagenesis by homologous recombination in D-melanogaster

YKS Rong et al.

GENES & DEVELOPMENT (2002)

Article Cell Biology

Cdc2-cyclin B kinase activity links Crb2 and Rqh1-topoisomerase III

T Caspari et al.

GENES & DEVELOPMENT (2002)

Article Biochemistry & Molecular Biology

Histone H2AX is phosphorylated in an ATR-dependent manner in response to replicational stress.

IM Ward et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2001)

Review Multidisciplinary Sciences

Initial sequencing and analysis of the human genome

ES Lander et al.

NATURE (2001)