☆ 4.7 Article

A strategy for enhancing bioactivity and osseointegration with antibacterial effect by incorporating magnesium in polylactic acid based biodegradable orthopedic implant

INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES (2024)

Related references

Note: Only part of the references are listed.

Article Materials Science, Multidisciplinary

Porous iron-reinforced polylactic acid TPMS bio-scaffolds: Interlocking reinforcement and synergistic degradation

Yong Xu et al.

Summary: Porous iron (pFe) was used as a reinforcing phase to strengthen poly (lactic acid) (PLA) matrix in PLA/pFe scaffolds. The incorporation of pFe significantly improved mechanical properties, with the PLA/5pFe scaffold showing a 121% higher mechanical performance than the PLA scaffold. The enhanced performance may be attributed to the spatial interlocks and encapsulations formed by the penetration of molten PLA molecules into the pore network of pFe particles, thereby enhancing stress transfer efficiency. Additionally, the PLA/pFe composite scaffold exhibited good biomineralization and cytocompatibility, making it promising for bone tissue engineering applications.

MATERIALS & DESIGN (2023)

Add to Collection

Article Engineering, Biomedical

Polyetheretherketone implants with hierarchical porous structure for boosted osseointegration

Zhiyong Chen et al.

Summary: A facile and effective surface modification strategy was developed to improve the osseointegration of PEEK implants. The modified PEEK substrate with a porous structure enhanced the adhesion, proliferation, and differentiation of BMSCs in vitro. In vivo tests showed that the surface-porous PEEK implants promoted new bone formation and achieved good bone integration with the host bone. This modification technique was also successfully applied to a medical PEEK interbody fusion cage.

BIOMATERIALS RESEARCH (2023)

Add to Collection

Article Materials Science, Multidisciplinary

Hybrid coatings for orthopaedic implants formed by physical vapour deposition and microarc oxidation

Roman Gabor et al.

Summary: This study focuses on preparing new hybrid layers for surface modification of Ti-6Al-4V alloys, which demonstrate excellent tribological properties and promote osteogenic differentiation of bone cells.

MATERIALS & DESIGN (2022)

Add to Collection

Article Chemistry, Multidisciplinary

Topography-Supported Nanoarchitectonics of Hybrid Scaffold for Systematically Modulated Bone Regeneration and Remodeling

Tae-Sik Jang et al.

Summary: Orthopedic implants reinforced with titanium dioxide nanoparticles via dopamine-induced polymerization and coated with hydroxyapatite show enhanced mechanical strength and biocompatibility. PEEK with internal TiO2 reinforcement improves bone cell proliferation and differentiation, while the HA coating leads to increased osteoblast absorption. Micro-CT and histological analyses confirm new bone formation and high bone-to-implant contact ratio on the HA-coated PEEK structure reinforced with TiO2 nanoparticles.

ADVANCED FUNCTIONAL MATERIALS (2022)

Add to Collection

Article Engineering, Biomedical

Biocompatibility evaluation of peo-treated magnesium alloy implants placed in rabbit femur condyle notches and paravertebral muscles

Seong Ryoung Kim et al.

Summary: Magnesium alloys have garnered significant attention for use in biodegradable metal implants due to their excellent mechanical properties and biocompatibility. However, their rapid breakdown and low bioactivity can lead to mechanical integrity loss before complete bone healing. To address these issues, zinc (Zn) and calcium (Ca) can be added to improve mechanical properties and biocompatibility. Another approach to improving mechanical properties is plasma electrolytic oxidation (PEO), which creates a dense, ceramic-like coating on the magnesium surface. This study evaluated the biocompatibility of high-purity magnesium, Mg-1wt%Zn-0.1wt%Ca alloy, and PEO-treated Mg-1wt%Zn-0.1wt%Ca alloy through radiographic and histological analyses. The results showed that Mg-1wt%Zn-0.1wt%Ca alloy exhibited higher corrosion resistance than high-purity magnesium and degraded safely over time without causing adverse reactions. Additionally, PEO treatment of Mg-1wt%Zn-0.1wt%Ca alloy positively affected fracture recovery by increasing bonding with bone. These findings suggest that PEO-treated Mg-1wt%Zn-0.1wt%Ca alloy holds promise as a biomaterial in various clinical situations, such as orthopedic and maxillofacial surgeries.

BIOMATERIALS RESEARCH (2022)

Add to Collection

Review Engineering, Biomedical

Surface coating of orthopedic implant to enhance the osseointegration and reduction of bacterial colonization: a review

Smriti Bohara et al.

Summary: The use of orthopedic implants in surgical technology has led to the restoration of physiological functions. However, there are various complications and limitations associated with these implants. Advancements in coating materials have shown potential in preventing implant failure, but most of these materials have not been successful in clinical tests. Implant failure rates have increased, resulting in physical discomfort and economic burdens. The development of systematic coating techniques has shown promising results in combating infection and enhancing bone integration.

BIOMATERIALS RESEARCH (2022)

Add to Collection

Article Engineering, Biomedical

Three-dimensionally printed biphasic calcium phosphate blocks with different pore diameters for regeneration in rabbit calvarial defects

Young-Wook Seo et al.

Summary: This study compared three-dimensionally printed biphasic calcium phosphate (BCP) block bone substitutes with different pore diameters for the regeneration of rabbit calvarial defects. The results showed that the BCP blocks remained unresorbed and new bone formation occurred within the porous structures of the blocks. After 2 weeks, histomorphometric analysis indicated that new bone formation was significantly greater in the BCP groups compared with the control group. However, there were no significant differences between the groups with different pore diameters. At 8 weeks, only the 1.0-mm group presented a significantly larger area of new bone compared with the control group. Among the BCP groups, the 1.0-mm and 1.2-mm groups exhibited significantly larger areas of new bone compared with the 0.8-mm group.

BIOMATERIALS RESEARCH (2022)

Add to Collection

Proceedings Paper Materials Science, Multidisciplinary

A review on enhancement of mechanical properties of fiber reinforcement polymer composite under different loading rates

Amir Khan et al.

Summary: Assessing and evaluating mechanical properties in composites is crucial. This study examines the morphological characterization and mechanical property enhancement of fiber-reinforced polymer composites with varying fiber weight percentages in an epoxy matrix. The research investigates the mechanical characteristics of natural and synthetic reinforcement composites in terms of toughness, impact strength, tensile strength, and fracture toughness under various loading rates.

MATERIALS TODAY-PROCEEDINGS (2022)

Add to Collection

Article Engineering, Biomedical

Enhanced osseointegration of dental implants with reduced graphene oxide coating

Yong Cheol Shin et al.

Summary: In this study, a bioactive surface modification for implant interface was implemented using reduced graphene oxide-coated titanium. The results showed that the graphene-coated titanium had better cell attachment and proliferation, alkaline phosphatase activity, matrix mineralization, expression of osteogenesis-related genes and protein, and osseointegration compared to the control group. This suggests that graphene-coated titanium could be a promising material for dental or orthopedic implants.

BIOMATERIALS RESEARCH (2022)

Add to Collection

Review Materials Science, Ceramics

Bioceramic composites for orthopaedic applications: A comprehensive review of mechanical, biological, and microstructural properties

Deepika Shekhawat et al.

Summary: Bioceramics are crucial in orthopaedic applications, where mechanical properties and biocompatibility are key considerations. By tailoring the microstructure, a balance between mechanical properties and biocompatibility of bioceramics can be achieved. Future advancements are needed to further promote innovation in bioceramics research.

CERAMICS INTERNATIONAL (2021)

Add to Collection

Article Surgery

Transforming the Degradation Rate of β-tricalcium Phosphate Bone Replacement Using 3-Dimensional Printing

Chen Shen et al.

Summary: The study used 3D-printed beta-TCP scaffolds with an osteogenic agent in rabbit models to accelerate degradation and promote vascularized, organized bone formation. This additive manufacturing approach shows promise for future craniofacial skeletal reconstruction as an effective bone tissue engineering method.

ANNALS OF PLASTIC SURGERY (2021)

Add to Collection

Article Materials Science, Multidisciplinary

The Role of Antibacterial Metallic Elements in Simultaneously Improving the Corrosion Resistance and Antibacterial Activity of Magnesium Alloys

Zhensheng Lin et al.

Summary: Magnesium-based biodegradable alloys show excellent mechanical properties and bioactivity in orthopedic applications, but their fast degradation rate may hinder the healing process. Alloying with antibacterial elements or coatings can enhance corrosion resistance without compromising antibacterial activity.

MATERIALS & DESIGN (2021)

Add to Collection

Article Engineering, Biomedical

Strength, corrosion resistance and cellular response of interfaces in bioresorbable poly-lactic acid/Mg fiber composites for orthopedic applications

Wahaaj Ali et al.

Summary: The study showed that immersion of poly-lactic acid/Mg fiber composites in simulated body fluid led to a decrease in interface shear strength, as a result of fast fiber corrosion and matrix cracking due to water diffusion. Cell culture tests revealed that early degradation of Mg fibers affected cell proliferation near the fibers. Surface modification of Mg fibers to delay degradation is crucial for further development of Mg/PLA composites for biomedical applications.

JOURNAL OF THE MECHANICAL BEHAVIOR OF BIOMEDICAL MATERIALS (2021)

Add to Collection

Article Biochemistry & Molecular Biology

Interfacial Compatibilization into PLA/Mg Composites for Improved In Vitro Bioactivity and Stem Cell Adhesion

Meriam Ben Abdeljawad et al.

Summary: This study highlights the crucial role of interfacial compatibilization in the design of PLA/Mg composites for bone regeneration applications. By incorporating an amphiphilic diblock copolymer, the interfacial adhesion between PLA and Mg was improved, leading to enhanced bioactivity while slightly decreasing mechanical performance. The results show that the copolymer addition could significantly improve the composite hydrophilicity and protein adsorption, ultimately promoting bone regeneration.

MOLECULES (2021)

Add to Collection

Article Polymer Science

Thermal Degradation Mechanism and Decomposition Kinetic Studies of Poly(Lactic Acid) and Its Copolymers with Poly(Hexylene Succinate)

Iouliana Chrysafi et al.

Summary: New block copolymers of PLA-b-PHSu in different mass ratios were synthesized and their thermal and mechanical behavior were studied using TGA, Py-GC/MS, and tensile measurements. The results showed that the copolymers decompose through the beta-hydrogen bond scission and exhibit increased elongation at break with higher PHSu content, indicating potential for further investigation for medical or other uses.

POLYMERS (2021)

Add to Collection

Article Metallurgy & Metallurgical Engineering

A combination strategy of functionalized polymer coating with Ta ion implantation for multifunctional and biodegradable vascular stents

Kwang-Hee Cheon et al.

Summary: The combination of PEI coating and Ta ion implantation effectively improves vascular compatibility and prevents in-stent restenosis and thrombosis by enhancing endothelial cell adhesion/proliferation and suppressing platelet adhesion/activation. This innovative approach provides a solution to the rapid corrosion and poor vascular compatibility issues faced by biodegradable magnesium stents.

JOURNAL OF MAGNESIUM AND ALLOYS (2021)

Add to Collection

Article Engineering, Biomedical

Bioceramic hydroxyapatite-based scaffold with a porous structure using honeycomb as a natural polymeric Porogen for bone tissue engineering

Mona Sari et al.

Summary: This study evaluated the effect of HCB concentration on the macropore structure of the scaffolds. The results showed that 30% HCB is the optimal concentration, meeting the criteria for pore structure, crystallographic properties, chemical decomposition process, and cell viability for bone tissue engineering.

BIOMATERIALS RESEARCH (2021)

Add to Collection

Article Engineering, Biomedical

Biosilicated collagen/β-tricalcium phosphate composites as a BMP-2-delivering bone-graft substitute for accelerated craniofacial bone regeneration

Dong Keon Lee et al.

Summary: By mimicking brown algae-inspired biosilicification and collagen coating, BMP-2 was effectively incorporated into the surface of β-TCP, promoting bone regeneration. This multicomposite bone substitute showed excellent bone regeneration effects in both in vitro and in vivo experiments.

BIOMATERIALS RESEARCH (2021)

Add to Collection

Article Materials Science, Multidisciplinary

3D-printed ceramic triply periodic minimal surface structures for design of functionally graded bone implants

Sanjairaj Vijayavenkataraman et al.

MATERIALS & DESIGN (2020)

Add to Collection

Article Polymer Science

Enhanced Bioactivity of Micropatterned Hydroxyapatite Embedded Poly(L-lactic) Acid for a Load-Bearing Implant

Sae-Mi Kim et al.

POLYMERS (2020)

Add to Collection

Article Materials Science, Multidisciplinary

An asymmetric surface coating strategy for improved corrosion resistance and vascular compatibility of magnesium alloy stents

Min-Ho Kang et al.

MATERIALS & DESIGN (2020)

Add to Collection

Article Engineering, Biomedical

Biomimetic porous Mg with tunable mechanical properties and biodegradation rates for bone regeneration

Min-Ho Kang et al.

ACTA BIOMATERIALIA (2019)

Add to Collection

Article Nanoscience & Nanotechnology

Enhanced Osseointegration Ability of Poly(lactic acid) via Tantalum Sputtering-Based Plasma Immersion Ion Implantation

Cheonil Park et al.

ACS APPLIED MATERIALS & INTERFACES (2019)

Add to Collection

Article Materials Science, Multidisciplinary

Atomic-scale and experimental investigation on the micro-structures and mechanical properties of PLA blending with CMC for additive manufacturing

Qinghua Wei et al.

MATERIALS & DESIGN (2019)

Add to Collection

Article Engineering, Biomedical

Effects of micro-porosity and local BMP-2 administration on bioresorption of beta-TCP and new bone formation

Atsuhito Kakuta et al.

BIOMATERIALS RESEARCH (2019)

Add to Collection

Article Engineering, Biomedical

Comparative studies on thin polycaprolactone-tricalcium phosphate composite scaffolds and its interaction with mesenchymal stem cells

Gopinathan Janarthanan et al.

BIOMATERIALS RESEARCH (2019)

Add to Collection

Article Engineering, Biomedical

Characterization of printed PLA scaffolds for bone tissue engineering

Agathe Gremare et al.

JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A (2018)

Add to Collection

Article Engineering, Biomedical

In vitro and in vivo evaluation of polylactic acid-based composite with tricalcium phosphate microsphere for enhanced biodegradability and osseointegration

Da Yong Shin et al.

JOURNAL OF BIOMATERIALS APPLICATIONS (2018)

Add to Collection

Review Microbiology

Implant infections: adhesion, biofilm formation and immune evasion

Carla Renata Arciola et al.

NATURE REVIEWS MICROBIOLOGY (2018)

Add to Collection

Article Materials Science, Multidisciplinary

Fabrication of 3D porous poly(lactic acid)-based composite scaffolds with tunable biodegradation for bone tissue engineering

Daoyong Mao et al.

MATERIALS & DESIGN (2018)

Add to Collection

Review Materials Science, Biomaterials

A comprehensive study on the fabrication and properties of biocomposites of poly(lactic acid)/ceramics for bone tissue engineering

Saeid Tajbakhsh et al.

MATERIALS SCIENCE AND ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS (2017)

Add to Collection

Article Materials Science, Composites

Development of PLA/Mg composite for orthopedic implant: Tunable degradation and enhanced mineralization

Changli Zhao et al.

COMPOSITES SCIENCE AND TECHNOLOGY (2017)

Add to Collection

Article Computer Science, Interdisciplinary Applications

To reduce the maximum stress and the stress shielding effect around a dental implant-bone interface using radial functionally graded biomaterials

H. Asgharzadeh Shirazi et al.

COMPUTER METHODS IN BIOMECHANICS AND BIOMEDICAL ENGINEERING (2017)

Add to Collection

Review Pharmacology & Pharmacy

Physical and mechanical properties of PLA, and their functions in widespread applications - A comprehensive review

Shady Farah et al.

ADVANCED DRUG DELIVERY REVIEWS (2016)

Add to Collection

Article Materials Science, Multidisciplinary

Physical and mechanical properties of PLA composites reinforced by TiO2 grafted flax fibers

MReza Foruzanmehr et al.

MATERIALS & DESIGN (2016)

Add to Collection

Article Multidisciplinary Sciences

A comparative study on the in vivo degradation of poly(L-lactide) based composite implants for bone fracture fixation

Zongliang Wang et al.

SCIENTIFIC REPORTS (2016)

Add to Collection

Article Engineering, Biomedical

Poly(ether imide)-silica hybrid coatings for tunable corrosion behavior and improved biocompatibility of magnesium implants

Min-Ho Kang et al.

BIOMEDICAL MATERIALS (2016)

Add to Collection

Article Engineering, Biomedical

Evaluating the effect of increasing ceramic content on the mechanical properties, material microstructure and degradation of selective laser sintered polycaprolactone/β-tricalcium phosphate materials

Heather Doyle et al.

MEDICAL ENGINEERING & PHYSICS (2015)

Add to Collection

Article Materials Science, Multidisciplinary

Development of tantalum scaffold for orthopedic applications produced by space-holder method

E. Ruperez et al.

MATERIALS & DESIGN (2015)

Add to Collection

Review Engineering, Biomedical

Implant osseointegration and the role of microroughness and nanostructures: Lessons for spine implants

Rolando A. Gittens et al.

ACTA BIOMATERIALIA (2014)

Add to Collection

Article Materials Science, Ceramics

Development and Characterization of Biphasic Hydroxyapatite/β-TCP Cements

Sara Gallinetti et al.

JOURNAL OF THE AMERICAN CERAMIC SOCIETY (2014)

Add to Collection

Article Engineering, Biomedical

Effects of Proliferation and Differentiation of Mesenchymal Stem Cells on Compressive Mechanical Behavior of Collagen/β-TCP Composite Scaffold

Takaaki Arahira et al.

JOURNAL OF THE MECHANICAL BEHAVIOR OF BIOMEDICAL MATERIALS (2014)

Add to Collection

Article Multidisciplinary Sciences

The Improved Biological Performance of a Novel Low Elastic Modulus Implant

Lei Shi et al.

PLOS ONE (2013)

Add to Collection

Review Biotechnology & Applied Microbiology

Development of Composite Scaffolds for Load-Bearing Segmental Bone Defects

Marcello Pilia et al.

BIOMED RESEARCH INTERNATIONAL (2013)

Add to Collection

Article Materials Science, Multidisciplinary

Improvement of surface bioactivity of poly(lactic acid) biopolymer by sandblasting with hydroxyapatite bioceramic

Ji-Young Bae et al.

MATERIALS LETTERS (2011)

Add to Collection

Review Biochemistry & Molecular Biology

Degradability of Polymers for Implantable Biomedical Devices

SuPing Lyu et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2009)

Add to Collection

Review Materials Science, Multidisciplinary

Ti based biomaterials, the ultimate choice for orthopaedic implants - A review

M. Geetha et al.

PROGRESS IN MATERIALS SCIENCE (2009)

Add to Collection

Article Engineering, Biomedical

An in vitro evaluation of the Ca/P ratio for the cytocompatibility of nano-to-micron particulate calcium phosphates for bone regeneration

Huinan Liu et al.

ACTA BIOMATERIALIA (2008)

Add to Collection

Article Polymer Science

A comparative study of the in vitro degradation of poly(L-lactic acid)/β-tricalcium phosphate scaffold in static and dynamic simulated body fluid

Yunqing Kang et al.

EUROPEAN POLYMER JOURNAL (2007)

Add to Collection

Article Engineering, Biomedical

How useful is SBF in predicting in vivo bone bioactivity?

T Kokubo et al.

BIOMATERIALS (2006)

Add to Collection

Review Engineering, Biomedical

Magnesium and its alloys as orthopedic biomaterials: A review

MP Staiger et al.

BIOMATERIALS (2006)

Add to Collection

Article Engineering, Biomedical

Effects of α-TCP and TetCP on MC3T3-E1 proliferation, differentiation and mineralization

A Ehara et al.

BIOMATERIALS (2003)

Add to Collection

Article Engineering, Biomedical

Mechanisms of magnesium-stimulated adhesion of osteoblastic cells to commonly used orthopaedic implants

H Zreiqat et al.

JOURNAL OF BIOMEDICAL MATERIALS RESEARCH (2002)

Add to Collection

Article Engineering, Biomedical

The biodegradation mechanism of calcium phosphate biomaterials in bone

JX Lu et al.

JOURNAL OF BIOMEDICAL MATERIALS RESEARCH (2002)

Add to Collection

Article Engineering, Biomedical

In vivo investigations on composites made of resorbable ceramics and poly(lactide) used as bone graft substitutes

AA Ignatius et al.

JOURNAL OF BIOMEDICAL MATERIALS RESEARCH (2001)

Add to Collection

Article Engineering, Biomedical

Clinical biocompatibility of biodegradable orthopaedic implants for internal fixation:: a review

O Böstman et al.

BIOMATERIALS (2000)

Add to Collection

© Peeref 2019-2024. All rights reserved.