Journal
FOOD CHEMISTRY
Volume 438, Issue -, Pages -Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.foodchem.2023.137963
Keywords
Luteolin; Sesame leaves; Exosomes; Delivery; Stability; Anti-inflammatory activity
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The study developed a novel nanocarrier Exo@Lu, which improved the water solubility and stability of Lu through encapsulation mechanism, enhancing bioavailability and efficacy in mitigating oxidative stress and inflammatory response.
The growing recognition of luteolin (Lu) as a vital functional component is attributed to its notable bioactive properties. However, the effective use of Lu is hindered by its inherent limitations related to water solubility, stability, and bioavailability. Here, we aim to develop sesame leaves-derived exosome-like nanovesicles (Exo) for Lu delivery (Exo@Lu) as vehicles. The encapsulation mechanism, solubility, stability, and bioactivity of Exo@Lu were thoroughly evaluated. Exo enriched abundant lipids, proteins, and phenolic compounds with an encap-sulation efficiency of -91.9 % and a loading capacity of -20.5 % for Lu. The primary binding forces responsible for the encapsulation were hydrogen bonds and van der Waals forces. After encapsulation, the water solubility and stability of Lu were significantly improved under various conditions, including thermal, light, storage, ionic strength, and pH. Exo@Lu maintained structural integrity during simulated digestion, enhancing bioaccessibility and efficacy in mitigating oxidative stress and inflammatory response compared to Exo and free Lu.
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