Journal
COMPUTERS IN BIOLOGY AND MEDICINE
Volume 168, Issue -, Pages -Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.compbiomed.2023.107718
Keywords
Fractional flow reserve; Coronary CTA; Multi-dimensional CFD framework; Boundary condition; Initial condition
Ask authors/readers for more resources
This study introduces a multi-dimensional CFD framework that improves the accuracy and efficiency of FFR prediction. The framework estimates 0D patient-specific boundary conditions and generates 3D initial conditions to enhance the prediction. The study demonstrates a strong correlation between the predicted FFR and the invasive FFR, with high accuracy and sensitivity.
Fractional flow reserve (FFR) is considered as the gold standard for diagnosing coronary myocardial ischemia. Existing 3D computational fluid dynamics (CFD) methods attempt to predict FFR noninvasively using coronary computed tomography angiography (CTA). However, the accuracy and efficiency of the 3D CFD methods in coronary arteries are considerably limited. In this work, we introduce a multi-dimensional CFD framework that improves the accuracy of FFR prediction by estimating 0D patient-specific boundary conditions, and increases the efficiency by generating 3D initial conditions. The multi-dimensional CFD models contain the 3D vascular model for coronary simulation, the 1D vascular model for iterative optimization, and the 0D vascular model for boundary conditions expression. To improve the accuracy, we utilize clinical parameters to derive 0D patient-specific boundary conditions with an optimization algorithm. To improve the efficiency, we evaluate the convergence state using the 1D vascular model and obtain the convergence parameters to generate appropriate 3D initial conditions. The 0D patient-specific boundary conditions and the 3D initial conditions are used to predict FFR (FFRC). We conducted a retrospective study involving 40 patients (61 diseased vessels) with invasive FFR and their corresponding CTA images. The results demonstrate that the FFRC and the invasive FFR have a strong linear correlation (r = 0.80, p < 0.001) and high consistency (mean difference: 0.014 +/- 0.071). After applying the cut-off value of FFR (0.8), the accuracy, sensitivity, specificity, positive predictive value, and negative predictive value of FFRC were 88.5%, 93.3%, 83.9%, 84.8%, and 92.9%, respectively. Compared with the conventional zero initial conditions method, our method improves prediction efficiency by 71.3% per case. Therefore, our multi-dimensional CFD framework is capable of improving the accuracy and efficiency of FFR prediction significantly.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available