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Secondary Metabolites from Fungi Microsphaeropsis spp.: Chemistry and Bioactivities

Journal

JOURNAL OF FUNGI
Volume 9, Issue 11, Pages -

Publisher

MDPI
DOI: 10.3390/jof9111093

Keywords

Microsphaeropsis; secondary metabolites; bioactivities

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Microsphaeropsis fungi are known for their production of secondary metabolites with potential medicinal value. This paper presents a systematic analysis of the secondary metabolites synthesized by Microsphaeropsis reported between 1980 and 2023, identifying 49 novel compounds among the 112 reported. A concise summary of their diverse biological activities is provided.
Microsphaeropsis, taxonomically classified within the kingdom fungi, phylum Ascomycota, subphylum Deuteromycotina, class Coelomycetes, order Sphaeropsidales, and family Sphaeropsidaceae, exhibit a ubiquitous distribution across various geographical regions. These fungi are known for their production of secondary metabolites, characterized by both structural novelty and potent biological activity. Consequently, they represent a significant reservoir for the advancement of novel pharmaceuticals. In this paper, a systematic review was present, marking the analysis of secondary metabolites synthesized by Microsphaeropsis reported between 1980 and 2023. A total of 112 compounds, comprising polyketones, macrolides, terpenoids, and nitrogen-containing compounds, were reported from Microsphaeropsis. Remarkably, among these compounds, 49 are novel discoveries, marking a significant contribution to the field. A concise summary of their diverse biological activities was provided, including antibacterial, antitumor, and antiviral properties and other bioactivities. This analysis stands as a valuable reference, poised to guide further investigations into the active natural products derived from Microsphaeropsis and their potential contributions to the development of medicinal resources.

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