Journal
ORAL SURGERY ORAL MEDICINE ORAL PATHOLOGY ORAL RADIOLOGY
Volume 122, Issue 2, Pages 164-173Publisher
ELSEVIER SCIENCE INC
DOI: 10.1016/j.oooo.2016.03.018
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Funding
- Nonprofit Industry Research Specific Fund of National Health and Family Planning Commission of China [201502018]
- National Natural Science Foundation of China [81470747, 81321002, 81200791, 81472533, 81102060, 81270040]
- International Science and Technology Cooperation Program of China [2012 DFA31370]
- Ministry of Education of China [20110181110055]
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Oral lichen planus (OLP) is a potentially premalignant condition with unknown pathogenesis. Immune and inflammatory factors are thought to play important roles in the development of OLP, and cytokines, such as interferon (IFN)-gamma and tumor necrosis factor (TNF)-alpha, can act as critical players in the immunopathogenesis of OLP. MicroRNAs (miRNAs) are closely correlated with cytokines in various inflammation-related diseases. In patients with OLP, miRNA-146a and miRNA-155 are increased in peripheral blood mononuclear cells, and numerous miRNAs have been shown to exhibit altered expression profiles in lesions. Although the microRNA-messenger RNA (miRNA-mRNA) network is thought to be involved in the development of OLP, in-depth studies are lacking. Here, we summarize current data on the mechanisms of action of miRNAs regulating typical cytokines in OLP, including interleukin (IL)-10, IL-17, IL-22, IFN-gamma, and TNF-alpha, to study the genetic basis of the pathogenesis of OLP and to provide prospects of therapy.
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