Coexistence of sarcopenia and self-reported weight loss is a powerful predictor of mortality in older patients with heart failure

Article Cardiac & Cardiovascular Systems

Prognostic relevance of gradual weight changes on long-term mortality in chronic heart failure

Tobias Taeger et al.

Summary: Obesity is associated with better outcomes in heart failure patients, while cachexia is linked to higher mortality. The prognostic impact of gradual, long-term weight changes in stable heart failure patients is not well understood.

NUTRITION METABOLISM AND CARDIOVASCULAR DISEASES (2023)

Add to Collection

Article Geriatrics & Gerontology

Association of weight change and in-hospital mortality in patients with repeated hospitalization for heart failure

Masaaki Konishi et al.

Summary: Weight loss and short/middle-term weight gain in patients with repeated hospitalization for heart failure are associated with high in-hospital mortality.

JOURNAL OF CACHEXIA SARCOPENIA AND MUSCLE (2023)

Add to Collection

Article Cardiac & Cardiovascular Systems

Extremes of both weight gain and weight loss are associated with increased incidence of heart failure and cardiovascular death: evidence from the CANVAS Program and CREDENCE

Giulia Ferrannini et al.

Summary: This study aimed to assess the associations between extreme weight changes and cardiovascular outcomes. The results showed that extreme weight gain or loss was associated with an increased risk of cardiovascular disease and heart failure hospitalization. For patients with type 2 diabetes and high cardiovascular risk, large changes in body weight should be carefully assessed in view of individualized management.

CARDIOVASCULAR DIABETOLOGY (2023)

Add to Collection

Article Geriatrics & Gerontology

Independent Association Between Use of Proton Pump Inhibitors and Muscle Wasting in Patients with Heart Failure: A Single-Center, Ambispective, Observational Study

Katsuhiko Ohori et al.

Summary: This study found that long-term use of proton pump inhibitors (PPIs) is associated with an increased risk of muscle wasting in heart failure (HF) patients. Therefore, caution should be exercised when performing long-term PPI treatment in HF patients at high risk of muscle wasting or with multiple risk factors.

DRUGS & AGING (2023)

Add to Collection

Article Cardiac & Cardiovascular Systems

Weight change and clinical outcomes in heart failure with reduced ejection fraction: insights from EMPEROR-Reduced

Stefan D. Anker et al.

Summary: In this study, the relationship between baseline BMI, weight loss, and the effects of empagliflozin on heart failure patients with reduced ejection fraction (HFrEF) were analyzed. The study found that the benefits of empagliflozin were consistent across all BMI categories, and weight loss was associated with increased risk of all-cause mortality regardless of treatment group.

EUROPEAN JOURNAL OF HEART FAILURE (2023)

Add to Collection

Article Cardiac & Cardiovascular Systems

Prevalence and prognostic impact of the coexistence of cachexia and sarcopenia in older patients with heart failure

Yudai Fujimoto et al.

Summary: This study examined the relationship between sar-copenia and cachexia in older patients with heart failure, and found that there is an overlap between these two conditions and they have prognostic implications. This study is of great importance for understanding the relevant diseases in patients with heart failure.

INTERNATIONAL JOURNAL OF CARDIOLOGY (2023)

Add to Collection

Article Multidisciplinary Sciences

Weight loss during follow-up in patients with acute heart failure: From the KCHF registry

Yuta Seko et al.

Summary: Weight loss of ≥5% at 6-month visit after discharge is associated with subsequent all-cause death in patients with AHF.

PLOS ONE (2023)

Add to Collection

Article Nutrition & Dietetics

Low Dietary Variety Is Associated with Incident Frailty in Older Adults during the Coronavirus Disease 2019 Pandemic: A Prospective Cohort Study in Japan

Miyuki Yokoro et al.

Summary: During the COVID-19 pandemic, the stagnation of social activity may lead to a decrease in motivation to maintain a healthy diet. This one-year follow-up study found an association between frailty in older adults and dietary variety. The results showed that individuals with low dietary variety had an increased frailty score during the COVID-19 pandemic.

NUTRIENTS (2023)

Add to Collection

Article Geriatrics & Gerontology

Prognostic impact of cachexia by multi-assessment in older adults with heart failure: FRAGILE-HF cohort study

Emi Maekawa et al.

Summary: This study aimed to investigate the association of Evans's criteria, consisting of multiple assessments, with the prognosis of HF in older adults. The findings showed that cachexia evaluated by multi-assessment was associated with a worse prognosis in older adults with HF. A multimodal assessment of cachexia may be helpful for risk stratification in older patients with HF.

JOURNAL OF CACHEXIA SARCOPENIA AND MUSCLE (2023)

Add to Collection

Article Cardiac & Cardiovascular Systems

Barthel Index Score Predicts Mortality in Elderly Heart Failure-A Goal of Comprehensive Cardiac Rehabilitation

Satoshi Katano et al.

Summary: This study found that comprehensive cardiac rehabilitation (CR) plays an important role in predicting mortality in elderly heart failure (HF) patients. The Barthel index (BI) score at discharge is negatively correlated with mortality rate.

CIRCULATION JOURNAL (2022)

Add to Collection

Article Multidisciplinary Sciences

Combined use of two frailty tools in predicting mortality in older adults

Daiki Watanabe et al.

Summary: This study aimed to verify the combined use of two frailty assessment tools in predicting mortality in older adults. The results showed that individuals who were identified as frail using both tools had a higher risk of death compared to those who were identified as frail using only one tool.

SCIENTIFIC REPORTS (2022)

Add to Collection

Article Cardiac & Cardiovascular Systems

Anthropometric parameters-derived estimation of muscle mass predicts all-cause mortality in heart failure patients

Satoshi Katano et al.

Summary: The aim of this study was to determine whether predicted ASMI serves as an alternative to DEXA-measured ASMI for predicting all-cause death in HF patients. The results showed that both predicted ASMI and DEXA-measured ASMI can predict all-cause death in HF patients.

ESC HEART FAILURE (2022)

Add to Collection

Article Cardiac & Cardiovascular Systems

Impact of weight loss in patients with heart failure with preserved ejection fraction: results from the FLAGSHIP study

Kenta Kamisaka et al.

Summary: The study found that weight loss is associated with adverse outcomes in non-obese HFpEF patients, but not in obese patients. This suggests that weight loss may be an indicator of worsening heart failure in non-obese patients.

ESC HEART FAILURE (2022)

Add to Collection

Article Endocrinology & Metabolism

Distinct determinants of muscle wasting in nonobese heart failure patients with and without type 2 diabetes mellitus

Toshiyuki Yano et al.

Summary: In patients with chronic heart failure (CHF) and diabetes mellitus (DM), differences were observed in muscle mass, cardiovascular disease, hypertension prevalence, estimated glomerular filtration rate (eGFR), plasma renin activity (PRA), and other factors. Nutritional assessment, blood glucose levels, and renin-angiotensin system activation may be associated with muscle wasting in CHF patients with DM.

JOURNAL OF DIABETES (2021)

Add to Collection

Article Cardiac & Cardiovascular Systems

Energy intake during hospital stay predicts all-cause mortality after discharge independently of nutritional status in elderly heart failure patients

Satoshi Katano et al.

Summary: This study found that low daily energy intake was independently associated with higher mortality in elderly HF patients, and inclusion of energy intake in addition to established predictors improved mortality risk stratification. Patients who consumed 31.5 kcal/kg/day of energy had the lowest risk of all-cause mortality.

CLINICAL RESEARCH IN CARDIOLOGY (2021)

Add to Collection

Article Cardiac & Cardiovascular Systems

Impact of sarcopenia on prognosis in patients with heart failure with reduced and preserved ejection fraction

Masaaki Konishi et al.

Summary: A multicentre prospective cohort study found that sarcopenia is an independent predictor of 1-year mortality in both HFpEF and HFrEF, with a similar impact on mortality in both patient groups.

EUROPEAN JOURNAL OF PREVENTIVE CARDIOLOGY (2021)

Add to Collection

Article Geriatrics & Gerontology

High percent body fat mass predicts lower risk of cardiac events in patients with heart failure: an explanation of the obesity paradox

Katsuhiko Ohori et al.

Summary: The study retrospectively analyzed data from 198 HF patients and found that higher body fat mass was associated with lower short-term cardiac event risk in HF patients, while muscle wasting was not significantly associated with cardiac events.

BMC GERIATRICS (2021)

Add to Collection

Article Cardiac & Cardiovascular Systems

Impact of weight loss in patients with heart failure with preserved ejection fraction: results from the FLAGSHIP study

Kenta Kamisaka et al.

Summary: This study identified weight loss as a poor prognostic factor for patients with heart failure, particularly in those with preserved ejection fraction who are not obese. Weight loss was significantly associated with all-cause mortality and HF rehospitalization in non-obese patients but not in obese patients. This suggests that weight loss should be monitored as an indicator of worsening heart failure in non-obese patients.

ESC HEART FAILURE (2021)

Add to Collection

Article Geriatrics & Gerontology

Prognostic impact of muscle and fat mass in patients with heart failure

Masaaki Konishi et al.

Summary: The study found that more than half of heart failure patients had reduced muscle mass, and lower values of both muscle and fat mass were associated with higher mortality in heart failure.

JOURNAL OF CACHEXIA SARCOPENIA AND MUSCLE (2021)

Add to Collection

Article Cardiac & Cardiovascular Systems

Loop diuretic use is associated with skeletal muscle wasting in patients with heart failure

Ippei Nakano et al.

Journal of Cardiology (2020)

Add to Collection

Article Geriatrics & Gerontology

Asian Working Group for Sarcopenia: 2019 Consensus Update on Sarcopenia Diagnosis and Treatment

Liang-Kung Chen et al.

JOURNAL OF THE AMERICAN MEDICAL DIRECTORS ASSOCIATION (2020)

Add to Collection

Article Medicine, General & Internal

A U-Shaped Relationship between the Prevalence of Frailty and Body Mass Index in Community-Dwelling Japanese Older Adults: The Kyoto-Kameoka Study

Daiki Watanabe et al.

JOURNAL OF CLINICAL MEDICINE (2020)

Add to Collection

Article Geriatrics & Gerontology

Overestimation of glomerular filtration rate by creatinine-based equation in heart failure patients is predicted by a novel scoring system

Tomoyuki Ishigo et al.

GERIATRICS & GERONTOLOGY INTERNATIONAL (2020)

Add to Collection

Article Geriatrics & Gerontology

Muscle wasting as an independent predictor of survival in patients with chronic heart failure

Stephan von Haehling et al.

JOURNAL OF CACHEXIA SARCOPENIA AND MUSCLE (2020)

Add to Collection

Article Cardiac & Cardiovascular Systems

Independent link between peripheral artery disease and muscle wasting in patients with heart failure

Katsuhiko Ohori et al.

ESC HEART FAILURE (2020)

Add to Collection

Article Cardiac & Cardiovascular Systems

Clinical Risk Factors and Prognostic Impact of Osteoporosis in Patients With Chronic Heart Failure

Satoshi Katano et al.

CIRCULATION JOURNAL (2020)

Add to Collection

Article Gastroenterology & Hepatology

Effect of loop diuretics on skeletal muscle depletion in patients with liver cirrhosis

Tatsunori Hanai et al.

HEPATOLOGY RESEARCH (2019)

Add to Collection

Article Cardiac & Cardiovascular Systems

JCS 2017/JHFS 2017 Guideline on Diagnosis and Treatment of Acute and Chronic Heart Failure - Digest Version -

Hiroyuki Tsutsui et al.

CIRCULATION JOURNAL (2019)

Add to Collection

Article Geriatrics & Gerontology

Sarcopenia: A Time for Action. An SCWD Position Paper

Juergen Bauer et al.

JOURNAL OF CACHEXIA SARCOPENIA AND MUSCLE (2019)

Add to Collection

Article Multidisciplinary Sciences

Loop diuretics are associated with greater risk of sarcopenia in patients with non-dialysis-dependent chronic kidney disease

Seiko Ishikawa et al.

PLOS ONE (2018)

Add to Collection

Article Cardiac & Cardiovascular Systems

Comparison of sarcopenia and cachexia in men with chronic heart failure: results from the Studies Investigating Co-morbidities Aggravating Heart Failure (SICA-HF)

Amir Emami et al.

EUROPEAN JOURNAL OF HEART FAILURE (2018)

Add to Collection

Review Medicine, General & Internal

Obesity and Heart Failure: Focus on the Obesity Paradox

Salvatore Carbone et al.

MAYO CLINIC PROCEEDINGS (2017)

Add to Collection

Article Multidisciplinary Sciences

Loop diuretics affect skeletal myoblast differentiation and exercise-induced muscle hypertrophy

Shintaro Mandai et al.

SCIENTIFIC REPORTS (2017)

Add to Collection

Article Cardiac & Cardiovascular Systems

Anorexia, functional capacity, and clinical outcome in patients with chronic heart failure: results from the Studies Investigating Co-morbidities Aggravating Heart Failure (SICA-HF)

Masakazu Saitoh et al.

ESC HEART FAILURE (2017)

Add to Collection

Article Medicine, General & Internal

Body-mass index and all-cause mortality: individual-participant-data meta-analysis of 239 prospective studies in four continents

Emanuele Di Angelantonio et al.

LANCET (2016)

Add to Collection

Article Geriatrics & Gerontology

Predictive Value of Frailty Scores for Healthy Life Expectancy in Community-Dwelling Older Japanese Adults

Minoru Yamada et al.

Journal of the American Medical Directors Association (2015)

Add to Collection

Article Cardiac & Cardiovascular Systems

Predicting survival in heart failure: validation of the MAGGIC heart failure risk score in 51 043 patients from the Swedish Heart Failure Registry

Ulrik Sartipy et al.

EUROPEAN JOURNAL OF HEART FAILURE (2014)

Add to Collection

Article Cardiac & Cardiovascular Systems

Application of the Seattle Heart Failure Model in Patients >80 Years of Age Enrolled in a Tertiary Care Heart Failure Clinic

Hanane Benbarkat et al.

AMERICAN JOURNAL OF CARDIOLOGY (2012)

Add to Collection

Article Cardiac & Cardiovascular Systems

Predictors of clinical outcomes in elderly patients with heart failure

Luis Manzano et al.

EUROPEAN JOURNAL OF HEART FAILURE (2011)

Add to Collection

Article Cardiac & Cardiovascular Systems

Multidimensional Prognostic Index Based on a Comprehensive Geriatric Assessment Predicts Short-Term Mortality in Older Patients With Heart Failure

Alberto Pilotto et al.

CIRCULATION-HEART FAILURE (2010)

Add to Collection

Editorial Material Cardiac & Cardiovascular Systems

The obesity paradox: weighing the benefit

Wolfram Doehner et al.

EUROPEAN HEART JOURNAL (2010)

Add to Collection

Article Medicine, General & Internal

Incidence and prevalence of heart failure in elderly persons, 1994-2003

Lesley H. Curtis et al.

ARCHIVES OF INTERNAL MEDICINE (2008)

Add to Collection

Article Medicine, General & Internal

Risk stratification for in-hospital mortality in acutely decompensated heart failure - Classification and regression tree analysis

GC Fonarow et al.

JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION (2005)

Add to Collection

Article Medicine, General & Internal

Predicting mortality among patients hospitalized for heart failure - Derivation and validation of a clinical model

DS Lee et al.

JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION (2003)

Add to Collection

Article Medicine, General & Internal

Prognostic importance of weight loss in chronic heart failure and the effect of treatment with angiotensin-converting-enzyme inhibitors: an observational study

SD Anker et al.

LANCET (2003)

Add to Collection

Coexistence of sarcopenia and self-reported weight loss is a powerful predictor of mortality in older patients with heart failure

Related references

Export Citation

Share Paper