The correlation between the main and minor lesions of synchronous multiple gastric neoplasms assessed gastroscopically and microscopically

Background Patients with early gastric cancer (EGC) are at high risk of developing synchronous multiple gastric neoplasms (SMGNs) after undergoing endoscopic submucosal dissection (ESD). However, most previous studies have had small sample sizes, and few have focused on association studies. Aims This study aimed to analyze the associations between SMGN lesion data from patients with EGC treated with ESD and their correlation coefficients. Methods The clinical ESD data from two hospitals from January 2008 to January 2021 were retrospectively analyzed. The main lesions were defined as those with a significant depth of infiltration. The larger tumor diameter was considered the main lesion if the lesions had the same infiltration depth. Results Of the 1013 post-ESD cases examined, 95 cases (223 lesions) had SMGN, and 25 patients had more than three lesions. For the correlation analysis, 190 lesions were included. The study revealed a similarity in pathological type between main and minor lesions (rs = 0.37) and a positive correlation in infiltration depth (rs = 0.58). The mean diameter sizes of the main and minor lesions were 20.7 +/- 8.3 mm and 13.1 +/- 6.4 mm, respectively, with statistically significant differences (P < 0.001). A linear correlation was observed between the diameter size and a linear regression model was constructed, producing r = 0.38 [95% confidence interval (CI) 0.19-0.54], b = 0.29 (95% CI 0.14-0.44), t = 3.94, P < 0.001]. A correlation was identified between the vertical distribution of the main and minor lesions, the horizontal distribution, and the gross endoscopic morphology (phi(c) = 0.25, P = 0.02; phi(c) = 0.32, P < 0.001; phi(c) = 0.60, P < 0.001). Conclusions The correlation coefficients for microscopic characteristics were higher than those for gastroscopy. There is a significant positive correlation between the main and minor lesions regarding pathological stage and depth of infiltration, respectively. The spatial distribution of the lesions and the gastroscopic morphology were similar.Graphical abstractSMGN synchronous multiple gastric neoplasms, ESD endoscopic submucosal dissection. [GRAPHICS]

Automated summary

This study analyzed the data of synchronous multiple gastric neoplasms (SMGN) in patients with early gastric cancer (EGC) treated with endoscopic submucosal dissection (ESD) and found similarities in pathological type and infiltration depth between the main and minor lesions. There was a positive correlation between the diameter size and a linear regression model was constructed. The spatial distribution of the lesions and the gastroscopic morphology were also found to be related.