Journal
SURFACES AND INTERFACES
Volume 44, Issue -, Pages -Publisher
ELSEVIER
DOI: 10.1016/j.surfin.2023.103628
Keywords
MgO; Chitosan; Antibacterial; Anticancer; Hybrid nanomaterials
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Surface modification of inorganic metal oxide nanoparticles with organic biopolymers has endowed these particles with multifunctional properties, making them versatile in the field of nanomedicine. In this study, magnesium oxide and chitosan modified magnesium oxide were synthesized using a green method. The antibacterial and anticancer activities of the synthesized hybrid nanomaterial were attributed to the generated reactive oxygen species. Chitosan modified magnesium oxide hybrid nanomaterial demonstrated appreciable efficacy against bacterial strains and showed significant anticancer potential against human breast cancer cells. Cytotoxicity assays on human fibroblast cells revealed high cell viability rates for both magnesium oxide and chitosan modified magnesium oxide hybrid nanomaterial. These findings suggest that chitosan modified magnesium oxide hybrid nanomaterial has promising applications in the biomedical field.
Surface modification of inorganic metal oxide nanoparticles with organic biopolymers has endowed these particles with multifunctional properties, making them versatile in the field of nanomedicine. In the present study, magnesium oxide and chitosan modified magnesium oxide is synthesised by green method. Amomum subulatum Roxb is used as a nucleating agent. Various characteristic techniques used on the synthesized hybrid nanomaterial demonstrated that the antibacterial and anticancer activities are attributed to the generated reactive oxygen species. The antibacterial activity exhibited appreciable efficacy of chitosan modified magnesium oxide hybrid nanomaterial against the tested bacterial strains compared to its counter parts. The zone of inhibition was in the range of 12-23 mm. Additionally, the anticancer potential was evaluated against human breast cancer cells, showing a significant effect for chitosan modified magnesium oxide hybrid nanomaterial with half-maximal inhibitory concentration of 35 mu g/mL and 40 mu g/mL for MgO. Cytotoxicity assays conducted on the human fibroblast L929 cell line revealed a cell viability rate of 80% and 87% for magnesium oxide and chitosan modified magnesium oxide hybrid nanomaterial. Overall, these findings indicate that chitosan modified magnesium oxide hybrid nanomaterial holds promise for applications in the biomedical field.
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