Cucurbitacin B and erastin co-treatment synergistically induced ferroptosis in breast cancer cells via altered iron-regulating proteins and lipid peroxidation

Review Oncology

Research progress on SLC7A11 in the regulation of cystine/cysteine metabolism in tumors

Xiang Tang et al.

Summary: SLC7A11, a major transporter regulating cysteine metabolism in tumor cells, plays a crucial role in tumor occurrence, development, invasion, and metastasis. It is expected to become a new therapeutic target and prognostic indicator for personalized treatment. Further research on SLC7A11 in tumors is important for screening, early diagnosis, treatment, and prognosis of patients.

ONCOLOGY LETTERS (2022)

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Review Biochemistry & Molecular Biology

Ferroptosis: A Trusted Ally in Combating Drug Resistance in Cancer

Erva Ozkan et al.

Summary: Ferroptosis, a novel cell death mechanism, shows potential therapeutic benefits in overcoming drug resistance in cancer. Cancer cells, which consume more iron, are particularly sensitive to ferroptosis, making it an excellent alternative for cell death induction and reversing drug resistance.

CURRENT MEDICINAL CHEMISTRY (2022)

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Article Oncology

Global cancer statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries

Hyuna Sung et al.

Summary: The global cancer burden in 2020 saw an estimated 19.3 million new cancer cases and almost 10.0 million cancer deaths. Female breast cancer surpassed lung cancer as the most commonly diagnosed cancer, while lung cancer remained the leading cause of cancer death. These trends are expected to rise in 2040, with transitioning countries experiencing a larger increase compared to transitioned countries due to demographic changes and risk factors associated with globalization and a growing economy. Efforts to improve cancer prevention measures and provision of cancer care in transitioning countries will be crucial for global cancer control.

CA-A CANCER JOURNAL FOR CLINICIANS (2021)

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Article Cell Biology