Journal
ADVANCED SYNTHESIS & CATALYSIS
Volume -, Issue -, Pages -Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/adsc.202301119
Keywords
C,C-palladacycles; C-H silylation; o-alkynylanilines; aminopalladation; disilylated 2-phenyl-1H-indoles
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Here, a Pd(II)-catalyzed C-H silylation of o-alkynylanilines with hexamethyldisilane for the synthesis of disilylated 2-phenyl-1H-indoles is reported. This method involves a sequence of aminopalladation, C-H activation, and dealkylation to form five-membered C,C-palladacycles, which then react with hexamethyldisilane to construct one C-N bond and two C-Si bonds. It provides an alternative strategy for C-H silylation.
Herein a Pd(II)-catalyzed C-H silylation of o-alkynylanilines with hexamethyldisilane for the synthesis of disilylated 2-phenyl-1H-indoles is reported. In this reaction, o-alkynylanilines undergo an aminopalladation, C-H activation, and dealkylation sequence to form five-membered C,C-palladacycles, which then couple with hexamethyldisilane to construct one C-N bond and two C-Si bonds. This method provides an alternative strategy for C-H silylation.
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