4.7 Article

Alternative for natural sweeteners: Improving the use of stevia as a source of steviol glycosides

Related references

Note: Only part of the references are listed.
Review Biochemistry & Molecular Biology

Steviol Glycosides from Stevia rebaudiana: An Updated Overview of Their Sweetening Activity, Pharmacological Properties, and Safety Aspects

Adriana Monserrath Orellana-Paucar

Summary: This literature-based review summarizes the scientific information on steviol glycosides as natural sweeteners and therapeutic molecules, while also addressing safety concerns. Steviol glycosides are sweeter than sucrose, but noncaloric, noncariogenic, and nonfermentative. They are recommended as alternative sweeteners due to their lack of harmful effects and exhibit various medicinal activities. Further clinical research is needed to explore their mechanisms of action and therapeutic applications.

MOLECULES (2023)

Article Agricultural Engineering

Biogenic synthesis, characterization and application of silver nanoparticles as biostimulator for growth and rebaudioside-A production in genetically stable stevia (Stevia rebaudiana Bert.) under in vitro conditions

Saroj Laha et al.

Summary: In this study, a simple and eco-friendly method for synthesizing silver nanoparticles (AgNPs) using leaf extract of in vitro banana plantlets was established. The synthesized AgNPs were characterized and then used to study their effects on the growth and rebaudioside-A content of stevia under in vitro conditions. The results showed that 400 μM AgNPs concentration in 'semi-solid followed by liquid' medium exhibited the best growth response and highest rebaudioside-A production.

INDUSTRIAL CROPS AND PRODUCTS (2023)

Article Agricultural Engineering

Long-day photoperiodic requirements for steviol glycosides and gibberellins biosynthesis and bio-sweetener levels optimization in Stevia rebaudiana Bertoni

Marcos V. S. de Andrade et al.

Summary: This study reports on the biosynthesis and contents of steviol glycosides (StGlys) in Stevia rebaudiana plants under different photoperiod conditions. The research found that plants developing under a 16/8-hour photoperiod had increased StGlys contents in the leaves, while the biosynthesis-related genes for gibberellins (GAs) in the stems were positively regulated. These findings are important for optimizing commercial production of Stevia rebaudiana.

INDUSTRIAL CROPS AND PRODUCTS (2023)

Review Biochemistry & Molecular Biology

Anti-Cancer Properties of Stevia rebaudiana; More than a Sweetener

Nikos Iatridis et al.

Summary: Stevia rebaudiana is a plant from Paraguay that is widely cultivated as a sugar substitute. Its derivatives have various beneficial biological activities, including anti-diabetic, antimicrobial, anti-inflammatory, and antitumor actions. This article provides a review of the biological actions of stevia derivatives in different types of tumors.

MOLECULES (2022)

Article Biochemistry & Molecular Biology

Effect of light intensity on steviol glycosides production in leaves of Stevia rebaudiana plants

Karel Vives Hernandez et al.

Summary: The study compared the content of stevioside and rebaudioside A in two commonly used S. rebaudiana cultivars, Morita II and Criolla, finding significant differences between them. Enhanced expression of three genes involved in SG biosynthesis in Morita II may contribute to its higher accumulation of rebaudioside A. Light conditions can affect SG accumulation, with higher light intensity leading to increased expression of biosynthetic genes and higher levels of stevioside and rebaudioside A.

PHYTOCHEMISTRY (2022)

Article Agronomy

Artificial Lighting Photoperiod Manipulation Approach to Improve Productivity and Energy Use Efficacies of Plant Factory Cultivated Stevia rebaudiana

Narendren Rengasamy et al.

Summary: This study found that photoperiod manipulation can increase productivity and energy use efficiency in indoor cultivation of Stevia rebaudiana plants in non-native environments. Continuous 16-hour photoperiod with supplemental red and blue light resulted in the highest biomass accumulation and metabolite yields.

AGRONOMY-BASEL (2022)

Article Engineering, Chemical

Steviol glycosides, an edible sweet surfactant that can modulate the interfacial and emulsifying properties of soy protein isolate solution

Tongtong Zhang et al.

Summary: The study found that the surface activities of steviol glycosides are related to their structure, and a mixture with soy protein isolate can reduce interfacial tension and enhance stability, especially rebaudioside A showed better tolerance to temperature, pH, and electrolytes. The binding of steviol glycosides and soy protein isolate mainly occurred by Van der Waals force and hydrogen bond, contributing to the potential application in food formulations.

JOURNAL OF FOOD ENGINEERING (2021)

Article Horticulture

The search towards cyto-embryological and physiological obstacles in sexual reproduction of Stevia rebaudiana Bertoni

Monika Tuleja et al.

Summary: Seed germination in Stevia rebaudiana is poor, limiting generative reproduction. The study suggests that improper levels of gibberellins and redirection of metabolic pathways for secondary metabolites biosynthesis may cause difficulties in pollen tube germination, affecting seed development in the plant.

SCIENTIA HORTICULTURAE (2021)

Review Biotechnology & Applied Microbiology

Synthesis and production of steviol glycosides: recent research trends and perspectives

Marta Libik-Konieczny et al.

Summary: Steviol glycosides (SvGls) are plant secondary metabolites found in a few plant species, including Stevia rebaudiana, and have been extensively researched for their sweetness and potential health benefits. Commercial cultivation and extraction technologies are already in place, but there is ongoing research to increase SvGls levels in plants. Further scientific research is needed to better understand the biochemistry and metabolism of SvGls for optimizing plant profiles and yields.

APPLIED MICROBIOLOGY AND BIOTECHNOLOGY (2021)

Article Agricultural Engineering

To cut or not to cut? That is the question in first year harvest of Stevia rebaudiana Bertoni production

Zoe Le Bihan et al.

Summary: The study on cultivating Stevia rebaudiana in temperate conditions found that avoiding harvest in the first year can facilitate better crop establishment, overwintering, and overall yield. Variability in response to overwintering, SG yield, and dry leaf biomass among different genotypes was observed, with a decrease in these traits for plants harvested in the first year.

INDUSTRIAL CROPS AND PRODUCTS (2021)

Article Biotechnology & Applied Microbiology

Gibberellin reverses the negative effect of paclobutrazol but not of chlorocholine chloride on the expression of SGs/GAs biosynthesis-related genes and increases the levels of relevant metabolites in Stevia rebaudiana

Simone Ribeiro Lucho et al.

Summary: The study demonstrates that steviol glycosides and gibberellins not only share the same molecular basis, but also have an intriguing coordination between their biosynthetic pathways. Treatment with gibberellic acid led to increased stevioside and phenolic compounds content, as well as significant downregulation of genes related to SGs/GAs biosynthesis. Additionally, the study shows that chlorocholine chloride and paclobutrazol have varying inhibitory effects on the synthesis pathways of stevioside, which can be partially reversed by subsequent treatment with gibberellic acid.

PLANT CELL TISSUE AND ORGAN CULTURE (2021)

Article Plant Sciences

Salinity Effects on Gene Expression, Morphological, and Physio-Biochemical Responses of Stevia rebaudiana Bertoni In Vitro

Clara R. Azzam et al.

Summary: The study aimed to propagate Stevia rebaudiana in vitro and investigated the salt stress tolerance of two varieties, revealing that Sugar High A3 is more tolerant than Spanti. Biochemical markers associated with salt tolerance, such as POD, PPO, and MDH, were identified, suggesting potential applications in stevia breeding programs.

PLANTS-BASEL (2021)

Article Biotechnology & Applied Microbiology

The productivity of Stevia rebaudiana (Bertoni) on dry leaves and steviol glycosides of four varieties grown in six regions of Morocco

Abdelkarim Khiraoui et al.

Summary: Stevia rebaudiana Bertoni is a perennial herbaceous plant that produces diterpene glycosides, a powerful natural low-calorie sweetener. This study found that region and varieties have significant effects on stevia dry leaf yield, steviol glycoside content, and steviol glycoside yield, with strong interactions between them.

BIOCATALYSIS AND AGRICULTURAL BIOTECHNOLOGY (2021)

Article Agricultural Engineering

Stevia rebaudiana (Bert.) Bertoni cultivated under different photoperiod conditions: Improving physiological and biochemical traits for industrial applications

Marcos Vinicius Silva de Andrade et al.

Summary: Research demonstrates that Stevia rebaudiana's response to light conditions affects the accumulation of antioxidant-like metabolites in its leaves, possibly linked to total phenolic content. Variations in SOD activity among plants under different photoperiods suggest a synergistic interaction between SOD isoforms and phenolic compounds to mitigate oxidative stress caused by light exposure.

INDUSTRIAL CROPS AND PRODUCTS (2021)

Article Plant Sciences

The chromosome-level Stevia genome provides insights into steviol glycoside biosynthesis

Xiaoyang Xu et al.

Summary: Stevia is well-known for its very sweet steviol glycosides, which are natural zero-calorie sweeteners. By annotating high-confidence protein-coding genes and identifying candidate genes involved in steviol glycoside biosynthesis, this research provides valuable insights into the evolutionary history of Stevia and the discovery of new genes for future breeding programs.

HORTICULTURE RESEARCH (2021)

Review Engineering, Chemical

A review on current conventional and biotechnical approaches to enhance biosynthesis of steviol glycosides in Stevia rebaudiana

Samra Basharat et al.

Summary: Stevia is a natural sweetener plant with highly potent and non-caloric steviol glycosides in its leaves. The demand for steviol glycosides is increasing globally, leading researchers to work on increasing production through biotechnological approaches. Stevia has become important in pharmaceuticals, food and beverages industries, but limited production is not meeting the growing market demand.

CHINESE JOURNAL OF CHEMICAL ENGINEERING (2021)

Article Food Science & Technology

Polyphenols from Stevia rebaudiana (Bertoni) leaves and their functional properties

Khaing Zar Myint et al.

JOURNAL OF FOOD SCIENCE (2020)

Review Food Science & Technology

Stevia rebaudiana Bertoni.: an updated review of its health benefits, industrial applications and safety

Jamil Ahmad et al.

TRENDS IN FOOD SCIENCE & TECHNOLOGY (2020)

Article Chemistry, Organic

The first total synthesis of rebaudioside R

Guo-En Wen et al.

ORGANIC & BIOMOLECULAR CHEMISTRY (2020)

Article Agronomy

Micropropagation of Stevia rebaudiana plants

Marta Teresa Rokosa et al.

CIENCIA RURAL (2020)

Review Environmental Sciences

Non-nutritive artificial sweeteners as an emerging contaminant in environment: A global review and risks perspectives

Sarva Mangala Praveena et al.

ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY (2019)

Review Food Science & Technology

A review of food reformulation of baked products to reduce added sugar intake

Xiao Luo et al.

TRENDS IN FOOD SCIENCE & TECHNOLOGY (2019)

Article Chemistry, Applied

Extraction with Water-in-Carbon Dioxide Microemulsions: A Case Study on Steviol Glycosides

Jingwen Cui et al.

JOURNAL OF SURFACTANTS AND DETERGENTS (2019)

Article Food Science & Technology

Simple and Efficient Green Extraction of Steviol Glycosides from Stevia rebaudiana Leaves

Veronica Lopez-Carbon et al.

FOODS (2019)

Article Biotechnology & Applied Microbiology

A bioeconomy perspective for natural sweetener Stevia

Rosaria Ciriminna et al.

BIOFUELS BIOPRODUCTS & BIOREFINING-BIOFPR (2019)

Article Biotechnology & Applied Microbiology

Overexpression of SrUGT76G1 in Stevia alters major steviol glycosides composition towards improved quality

Mi Jung Kim et al.

PLANT BIOTECHNOLOGY JOURNAL (2019)

Article Nutrition & Dietetics

A polyol-stevia blended sugar replacer exhibits low glycemic response among human subjects

Allan W. R. Ng et al.

CLINICAL NUTRITION ESPEN (2019)

Article Nutrition & Dietetics

Stevia Leaf to Stevia Sweetener: Exploring Its Science, Benefits, and Future Potential

Priscilla Samuel et al.

JOURNAL OF NUTRITION (2018)

Article Biotechnology & Applied Microbiology

Induction, identification and characterization of polyploidy in Stevia rebaudiana Bertoni

Hong Zhang et al.

PLANT BIOTECHNOLOGY (2018)

Article Food Science & Technology

FDA regulatory approach to steviol glycosides

Judith D. Perrier et al.

FOOD AND CHEMICAL TOXICOLOGY (2018)

Review Biotechnology & Applied Microbiology

Recent advances in biological production of erythritol

Dorota A. Rzechonek et al.

CRITICAL REVIEWS IN BIOTECHNOLOGY (2018)

Article Biochemistry & Molecular Biology

Effect of nitrogen sources on gene expression of Stevia rebaudiana (Bertoni) under in vitro conditions

Fariba Akbari et al.

CELLULAR AND MOLECULAR BIOLOGY (2018)

Article Biochemistry & Molecular Biology

Effects of various glutamine concentrations on gene expression and steviol glycosides accumulation in Stevia rebaudiana Bertoni

Fatemeh Esmaeili et al.

CELLULAR AND MOLECULAR BIOLOGY (2018)

Article Biochemistry & Molecular Biology

Effects of life cycle and leaves location on gene expression and glycoside biosynthesis pathway in Stevia rebaudiana Bertoni

Matin Ghaheri et al.

CELLULAR AND MOLECULAR BIOLOGY (2018)

Article Biochemistry & Molecular Biology

Effects of different concentrations of mannitol on gene expression in Stevia rebaudiana Bertoni

Somayeh Hashempoor et al.

CELLULAR AND MOLECULAR BIOLOGY (2018)

Article Biochemistry & Molecular Biology

Callus induction and somatic embryogenesis in Stevia rebaudiana Bertoni as a medicinal plant

Tahereh Keshvari et al.

CELLULAR AND MOLECULAR BIOLOGY (2018)

Review Food Science & Technology

Biological activity of Stevia rebaudiana Bertoni and their relationship to health

Jorge Carlos Ruiz-Ruiz et al.

CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION (2017)

Review Food Science & Technology

Sweeteners as food additives in the XXI century: A review of what is known, and what is to come

Marcio Carocho et al.

FOOD AND CHEMICAL TOXICOLOGY (2017)

Article Biochemistry & Molecular Biology

Steviol glycosides correlation to genes transcription revealed in gibberellin and paclobutrazol-treated Stevia rebaudiana

Shokoofeh Hajihashemi et al.

JOURNAL OF PLANT BIOCHEMISTRY AND BIOTECHNOLOGY (2017)

Article Chemistry, Medicinal

Morpho-anatomical study of Stevia rebaudiana roots grown in vitro and in vivo

Rafael V. Reis et al.

REVISTA BRASILEIRA DE FARMACOGNOSIA-BRAZILIAN JOURNAL OF PHARMACOGNOSY (2017)

Article Multidisciplinary Sciences

Steviol glycosides enhance pancreatic beta-cell function and taste sensation by potentiation of TRPM5 channel activity

Koenraad Philippaert et al.

NATURE COMMUNICATIONS (2017)

Article Chemistry, Medicinal

Morpho-anatomical study of Stevia rebaudiana roots grown in vitro and in vivo

Rafael V. Reis et al.

REVISTA BRASILEIRA DE FARMACOGNOSIA-BRAZILIAN JOURNAL OF PHARMACOGNOSY (2017)

Article Biochemistry & Molecular Biology

A Novel Diterpene Glycoside with Nine Glucose Units from Stevia rebaudiana Bertoni

Indra Prakash et al.

BIOMOLECULES (2017)

Review Nutrition & Dietetics

The role of artificial and natural sweeteners in reducing the consumption of table sugar: A narrative review

Arshag D. Mooradian et al.

CLINICAL NUTRITION ESPEN (2017)

Review Biochemistry & Molecular Biology

From obesity to cancer: a review on proposed mechanisms

Zoya Tahergorabi et al.

CELL BIOCHEMISTRY AND FUNCTION (2016)

Article Plant Sciences

Rebaudiosides R and S, Minor Diterpene Glycosides from the Leaves of Stevia rebaudiana

Mohamed A. Ibrahim et al.

JOURNAL OF NATURAL PRODUCTS (2016)

Article Psychology, Biological

Trends in the consumption of low-calorie sweeteners

Allison C. Sylvetsky et al.

PHYSIOLOGY & BEHAVIOR (2016)

Article Plant Sciences

Micropropagation of Stevia rebaudiana Bert. in temporary immersion systems and evaluation of genetic fidelity

M. A. Ramirez-Mosqueda et al.

SOUTH AFRICAN JOURNAL OF BOTANY (2016)

Review Genetics & Heredity

High-throughput functional genomics using CRISPR-Cas9

Ophir Shalem et al.

NATURE REVIEWS GENETICS (2015)

Article Food Science & Technology

Modification of steviol glycosides using α-amylase

Fayin Ye et al.

LWT-FOOD SCIENCE AND TECHNOLOGY (2014)

Review Food Science & Technology

Development of Next Generation Stevia Sweetener: Rebaudioside M

Indra Prakash et al.

FOODS (2014)

Review Plant Sciences

Steviol Glycosides: Chemical Diversity, Metabolism, and Function

Stijn Ceunen et al.

JOURNAL OF NATURAL PRODUCTS (2013)

Article Agriculture, Multidisciplinary

Stability of Steviol Glycosides in Several Food Matrices

Etienne Jooken et al.

JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY (2012)

Review Agriculture, Multidisciplinary

The Leaves of Stevia rebaudiana (Bertoni), Their Constituents and the Analyses Thereof: A Review

Ursula Woelwer-Rieck

JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY (2012)

Article Plant Sciences

Stimulation of steviol glycoside accumulation in Stevia rebaudiana by red LED light

Stijn Ceunen et al.

JOURNAL OF PLANT PHYSIOLOGY (2012)

Review Agronomy

A review on the improvement of stevia [Stevia rebaudiana (Bertoni)]

Ashok Kumar Yadav et al.

CANADIAN JOURNAL OF PLANT SCIENCE (2011)

Article Agriculture, Multidisciplinary

Identification and Quantification of Major Steviol Glycosides in Stevia rebaudiana Purified Extracts by 1H NMR Spectroscopy

Valerio Pieri et al.

JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY (2011)

Article Plant Sciences

UDP-dependent glycosyltransferases involved in the biosynthesis of steviol glycosides

Amal A. A. Mohamed et al.

JOURNAL OF PLANT PHYSIOLOGY (2011)

Article Food Science & Technology

Stevioside and Stevia-sweetener in food: application, stability and interaction with food ingredients

Gerhard Kroyer

JOURNAL FUR VERBRAUCHERSCHUTZ UND LEBENSMITTELSICHERHEIT-JOURNAL OF CONSUMER PROTECTION AND FOOD SAFETY (2010)

Article Agriculture, Multidisciplinary

Photostability of rebaudioside A and stevioside in beverages

John F. Clos et al.

JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY (2008)

Article Biochemistry & Molecular Biology

Steviol glycoside biosynthesis

J. E. Brandle et al.

PHYTOCHEMISTRY (2007)

Article Agriculture, Multidisciplinary

Metabolism of stevioside and rebaudioside A from Stevia rebaudiana extracts by human microflora

C Gardana et al.

JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY (2003)

Article Plant Sciences

In vitro culture studies on Stevia rebaudiana

L Sivaram et al.

IN VITRO CELLULAR & DEVELOPMENTAL BIOLOGY-PLANT (2003)