4.3 Article

Selenium and selenoproteins role in Parkinson's disease: Is there a link between selenoproteins and accumulated alpha-synuclein?

Related references

Note: Only part of the references are listed.
Review Clinical Neurology

Neuropathology of α-synuclein in Parkinson's disease

Chi-Jing Choong et al.

Summary: Parkinson's disease is a neurodegenerative disorder characterized by progressive movement disability and non-motor symptoms. The loss of dopaminergic neurons and the presence of Lewy bodies are the neuropathological hallmarks of the disease. Studies have shown that the propagation of alpha Syn plays a significant role in the spread of the pathology.

NEUROPATHOLOGY (2022)

Review Biochemistry & Molecular Biology

Selenium Effects on Oxidative Stress-Induced Calcium Signaling Pathways in Parkinson's Disease

Sanaz Salaramoli et al.

Summary: This article identifies the important roles of selenium and calcium in the pathogenesis of Parkinson's disease. The antioxidant properties of selenium can affect calcium signaling and alleviate complications associated with oxidative stress.

INDIAN JOURNAL OF CLINICAL BIOCHEMISTRY (2022)

Review Biochemistry & Molecular Biology

Selenoprotein P - Selenium transport protein, enzyme and biomarker of selenium status

Lutz Schomburg

Summary: The habitual intake of selenium varies across the world, putting many people at risk of selenium deficiency and related health risks. SELENOP plays an important role in selenium transport to vital organs, such as endocrine glands and the brain. SELENOP deficiency is associated with health risks, and circulating SELENOP concentrations serve as a biomarker of selenium supply. SELENOP may have enzymatic activity and protective functions, but its role in the intact organism is still unclear. SELENOP-dependent selenium transport is an important and modifiable risk factor for cardiovascular and critical diseases, cancer, and autoimmune thyroiditis.

FREE RADICAL BIOLOGY AND MEDICINE (2022)

Review Food Science & Technology

Selenium and selenoproteins: their function and development of selenium-rich foods

Mengqing Han et al.

Summary: This paper reviews the physiological processes of Selenium, the development and utilization of Se-enriched foods, and the research on the properties of selenoproteins. It also provides some suggestions and prospects for developing Se-rich food in the future.

INTERNATIONAL JOURNAL OF FOOD SCIENCE AND TECHNOLOGY (2022)

Article Neurosciences

Selenium level does not differ in blood but increased in cerebrospinal fluid in Parkinson's disease: a meta-analysis

Yu-Jing Zhang et al.

Summary: Selenium levels are associated with the risk of Parkinson's disease, with significantly higher cerebrospinal fluid selenium levels found in PD patients compared to controls. The findings can contribute to a better understanding of the association between selenium and PD.

INTERNATIONAL JOURNAL OF NEUROSCIENCE (2021)

Review Toxicology

The Impact of Environmental Factors on Monogenic Mendelian Diseases

Anke M. Tukker et al.

Summary: Environmental factors and gene-environment interactions can modify the expression and onset of Mendelian genetic diseases, providing insight into complex disease phenotypes. Studying monogenic model systems may help understand the pathogenesis of complex diseases.

TOXICOLOGICAL SCIENCES (2021)

Article Clinical Neurology

A Multi-Step Model of Parkinson's Disease Pathogenesis

Campbell Le Heron et al.

Summary: The age-specific incidence of Parkinson's disease suggests a multistep pathogenic process, with an average of six steps before age 45 and eight steps after. The model supports theories that emphasize the role of environmental factors in driving sex differences in disease incidence.

MOVEMENT DISORDERS (2021)

Article Biochemistry & Molecular Biology

Selenium speciation analysis in the cerebrospinal fluid of patients with Parkinson's disease

Fabian Maass et al.

JOURNAL OF TRACE ELEMENTS IN MEDICINE AND BIOLOGY (2020)

Review Biochemistry & Molecular Biology

Selenium, selenoprotein P, and Alzheimer's disease: is there a link?

Nikolay Solovyev et al.

FREE RADICAL BIOLOGY AND MEDICINE (2018)

Article Biochemistry & Molecular Biology

Selenoprotein S is required for clearance of C99 through endoplasmic reticulum-associated degradation

Jun Ki Jang et al.

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2017)

Review Neurosciences

Endoplasmic reticulum stress in brain ischemia

Yingchao Su et al.

INTERNATIONAL JOURNAL OF NEUROSCIENCE (2016)

Article Oncology

The activity and tissue distribution of thioredoxin reductase in basal cell carcinoma

Maryam Sobhani et al.

JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY (2016)

Article Biochemistry & Molecular Biology

Selenoprotein S-dependent Selenoprotein K Binding to p97(VCP) Protein Is Essential for Endoplasmic Reticulum-associated Degradation

Jea Hwang Lee et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2015)

Review Biochemistry & Molecular Biology

Selenium and Selenoprotein Function in Brain Disorders

Roshan Pillai et al.

IUBMB LIFE (2014)

Article Clinical Neurology

α-Synuclein inclusions in the skin of Parkinson's disease and parkinsonism

Ildefonso Rodriguez-Leyva et al.

ANNALS OF CLINICAL AND TRANSLATIONAL NEUROLOGY (2014)

Article Multidisciplinary Sciences

A longitudinal study on α-synuclein in blood plasma as a biomarker for Parkinson's disease

Penelope G. Foulds et al.

SCIENTIFIC REPORTS (2013)

Article Neurosciences

Selenium from dietary sources and motor functions in the Brazilian Amazon

Melanie Lemire et al.

NEUROTOXICOLOGY (2011)

Article Geriatrics & Gerontology

LOW SERUM CAROTENOIDS ARE ASSOCIATED WITH A DECLINE IN WALKING SPEED IN OLDER WOMEN

N. Alipanah et al.

JOURNAL OF NUTRITION HEALTH & AGING (2009)

Article Biochemistry & Molecular Biology

OXIDATIVE STRESS IN PARKINSON'S DISEASE

Shashikant Nikam et al.

INDIAN JOURNAL OF CLINICAL BIOCHEMISTRY (2009)

Article Neurosciences

A systems level analysis of transcriptional changes in Alzheimer's disease and normal aging

Jeremy A. Miller et al.

JOURNAL OF NEUROSCIENCE (2008)

Review Biochemistry & Molecular Biology

Redox regulation of cellular stress response in aging and neurodegenerative disorders: Role of vitagenes

Vittorio Calabrese et al.

NEUROCHEMICAL RESEARCH (2007)

Review Medicine, General & Internal

Genomic medicine: Alzheimer's disease and Parkinson's disease

RL Nussbaum et al.

NEW ENGLAND JOURNAL OF MEDICINE (2003)