4.6 Article

Melatonin promotes progesterone secretion in sheep luteal cells by regulating autophagy via the AMPK/mTOR pathway

Related references

Note: Only part of the references are listed.
Review Cell Biology

Acetylation in the regulation of autophagy

Yinfeng Xu et al.

Summary: This review summarizes the importance of acetylation modifications in the regulation of autophagy and their regulatory roles on multiple autophagy proteins. Acetylation regulates autophagy initiation, autophagosome formation, and transcriptional regulation by targeting core protein complexes and key regulatory molecules.

AUTOPHAGY (2023)

Article Multidisciplinary Sciences

METTL3 is essential for normal progesterone signaling during embryo implantation via m(6)A-mediated translation control of progesterone receptor

Zhan-Hong Zheng et al.

Summary: m(6)A modification plays a crucial role in embryo implantation by maintaining P-4 signaling. METTL3 enhances the translation efficiency of PGR protein by modifying Pgr mRNA with m(6)A, thereby affecting the process of embryo implantation.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2023)

Article Agriculture, Dairy & Animal Science

Effects of two protocols of ovulation synchronization on corpus luteum size and blood flow, progesterone concentration, and pregnancy rate in beef heifers

Pablo Sebastian Reineri et al.

Summary: The study aimed to evaluate the effects of 7-day estradiol-progesterone-based and 5-day Co-Synch plus progesterone protocols on various reproductive parameters in beef heifers. The results showed that there were differences in ovulation time, progesterone concentration, corpus luteum size, and blood flow between the two protocols. However, there was no difference in pregnancy rate between the two groups.

ANIMAL REPRODUCTION SCIENCE (2023)

Review Developmental Biology

Progesterone signaling in the regulation of luteal steroidogenesis

Kayhan Yakin et al.

Summary: The corpus luteum is the main source of progesterone, and understanding its signaling pathways is crucial for managing reproductive disorders. This review focuses on the complex mechanisms of progesterone-induced signaling in luteal granulosa cell activity and discusses future research priorities and limitations of the current data.

MOLECULAR HUMAN REPRODUCTION (2023)

Article Reproductive Biology

Melatonin administration during the first half of pregnancy improves the reproductive performance of rabbits: Emphasis on ovarian and placental functions

Nesrein M. Hashem et al.

Summary: This study aimed to investigate the effects of melatonin administration during different sensitive windows of the first half of pregnancy on ovarian and placental function and gene expression, hormone profile, and pregnancy outcomes in rabbits. The study found that melatonin administration increased the number of visible follicles, reduced the number of absorbed fetuses, and improved the weights of embryonic sacs and fetuses. Melatonin treatment also improved the expression of antioxidant, gonadotropin receptor, and cell cycle regulatory genes in the ovary, as well as the expression of most genes in the placenta.

THERIOGENOLOGY (2023)

Article Environmental Sciences

Ambient fine particulate matter exposure disrupts placental autophagy and fetal development in gestational mice

Ran Li et al.

Summary: Recent studies have found that gestational exposure to ambient fine particulate matter (PM2.5) is associated with adverse pregnancy outcomes, particularly intrauterine growth restriction (IUGR). However, the underlying mechanism is still unclear. In this study, pregnant mice were exposed to either filtered air or ambient PM2.5, and it was found that PM2.5 exposure during gestation resulted in reduced fetal body weight and crown-rump length. Moreover, the placental blood sinusoid and expression of placental nutrient transporters and growth hormone were also affected by PM2.5 exposure. Additional tests revealed that PM2.5 exposure inhibited autophagy and activated the AMPK/mTOR signaling pathway in the placenta. These findings suggest that autophagy inhibition leading to placental developmental disorder might be an important mechanism for PM2.5-induced growth restriction.

ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY (2022)

Article Public, Environmental & Occupational Health

Melatonin suppresses serum starvation-induced autophagy of ovarian granulosa cells in premature ovarian insufficiency

Di Wu et al.

Summary: This study revealed that MT inhibits autophagy of granulosa cells in women with premature ovarian insufficiency (POI) by modulating the miR-15a-5p/Stat3/PI3K-Akt-mTOR pathway, shedding light on the potential protective mechanism of MT in POI.

BMC WOMENS HEALTH (2022)

Article Biochemistry & Molecular Biology

Immunolocalization of melatonin receptor type 1 in the sheep ovary and involvement of the PI3K/Akt/FOXO3a signaling pathway in the effects of melatonin on survival and in vitro activation of primordial follicles

Ricassio S. Barberino et al.

Summary: This study investigated the expression of melatonin receptor type 1 (MT1) protein in sheep ovaries and evaluated the effects of melatonin on the survival and development of primordial follicles after in vitro culture. The results showed that 100 pg/ml melatonin could increase follicular survival and activation. Inhibition of the PI3K pathway resulted in increased apoptosis and decreased activation of primordial follicles. These findings suggest that 100 pg/ml melatonin can promote the survival and activation of primordial follicles through the PI3K signaling pathway in sheep ovarian tissue culture.

MOLECULAR REPRODUCTION AND DEVELOPMENT (2022)

Article Agriculture, Dairy & Animal Science

Immunolocalization of melatonin receptors in bovine ovarian follicles and in vitro effects of melatonin on growth, viability and gene expression in secondary follicles

L. R. F. M. Paulino et al.

Summary: This study investigates the expression of melatonin receptor types 1A/B in bovine ovaries and the effects of melatonin on follicle development and antioxidant enzyme expression. The results show that melatonin promotes follicle growth through its membrane-coupled receptors, while the melatonin receptor antagonist luzindole blocks its effects.

DOMESTIC ANIMAL ENDOCRINOLOGY (2022)

Article Reproductive Biology

Melatonergic systems of AANAT, melatonin, and its receptor MT2 in the corpus luteum are essential for reproductive success in mammals

Jing Wang et al.

Summary: The study reveals strong expression of melatonin synthetic enzyme and MT2 genes in the corpus luteum of mammals, where KO MT2 significantly affects reproductive performance. Melatonin treatment enhances progesterone production and improves corpus luteum function, mediated by MT2.

BIOLOGY OF REPRODUCTION (2021)

Article Medicine, Research & Experimental

Roles of melatonin in the field of reproductive medicine

Wei Yong et al.

Summary: Melatonin is a multifunctional hormone regulated by the circadian rhythm, with roles in sleep-wake cycle rhythms, ageing retardation, antioxidant and anti-inflammatory functions, as well as significant impact on reproductive functions.

BIOMEDICINE & PHARMACOTHERAPY (2021)

Article Environmental Sciences

Melatonin alleviates benzo(a)pyrene-induced ovarian corpus luteum dysfunction by suppressing excessive oxidative stress and apoptosis

Hanting Xu et al.

Summary: The study revealed that Benzo(a)pyrene (B(a)P) affects embryo implantation and ovarian CL function in pregnant mice, leading to decreased levels of estrogen and progesterone in the ovaries and impacting oxidative stress and cell apoptosis. Additionally, melatonin was found to alleviate B(a)P-induced ovarian dysfunction by reducing oxidative stress and apoptosis, providing a potential protective mechanism against B(a)P exposure through the melatonin receptor pathway.

ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY (2021)

Review Medicine, General & Internal

Immune Tolerance of the Human Decidua

Hiromi Murata et al.

Summary: The endometrium is essential for implantation, placental development, and successful pregnancy, undergoing cycles of proliferation, differentiation, and shedding. Immune cells in the endometrium, with conflicting functions of protection and tolerance towards the embryo, are significantly influenced by progesterone. Key molecules like interleukin-15 play pivotal roles in immune tolerance and pregnancy establishment.

JOURNAL OF CLINICAL MEDICINE (2021)

Review Biochemistry & Molecular Biology

Autophagy in Ovarian Follicular Development and Atresia

Jiawei Zhou et al.

INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES (2019)

Article Agriculture, Dairy & Animal Science

The expression of autophagy-related proteins within the corpus luteum lifespan in pigs

M. Grzesiak et al.

DOMESTIC ANIMAL ENDOCRINOLOGY (2018)

Article Agriculture, Dairy & Animal Science

Expression of melatonin and its related synthase and membrane receptors in the oestrous corpus luteum and corpus luteum verum of sheep

Longfei Xiao et al.

REPRODUCTION IN DOMESTIC ANIMALS (2018)

Review Biochemistry & Molecular Biology

An Overview of Autophagy: Morphology, Mechanism, and Regulation

Katherine R. Parzych et al.

ANTIOXIDANTS & REDOX SIGNALING (2014)

Article Endocrinology & Metabolism

Progesterone is critical for the development of mouse embryos

Cong Zhang et al.

ENDOCRINE (2014)

Article Agriculture, Dairy & Animal Science

Cellular and functional characterization of buffalo (Bubalus bubalis) corpus luteum during the estrous cycle and pregnancy

Rubina Kumari Baithalu et al.

ANIMAL REPRODUCTION SCIENCE (2013)

Letter Medicine, General & Internal

Autophagy in Human Health and Disease REPLY

Augustine M. K. Choi et al.

NEW ENGLAND JOURNAL OF MEDICINE (2013)

Review Medicine, General & Internal

MECHANISMS OF DISEASE Autophagy in Human Health and Disease

Augustine M. K. Choi et al.

NEW ENGLAND JOURNAL OF MEDICINE (2013)

Article Reproductive Biology

The Role of Autophagy in Corpus Luteum Regression in the Rat

JongYeob Choi et al.

BIOLOGY OF REPRODUCTION (2011)

Review Biochemistry & Molecular Biology

Autophagy: Renovation of Cells and Tissues

Noboru Mizushima et al.

Article Endocrinology & Metabolism

Protective role of melatonin in progesterone production by human luteal cells

Toshiaki Taketani et al.

JOURNAL OF PINEAL RESEARCH (2011)

Article Cell Biology

AMPK and mTOR regulate autophagy through direct phosphorylation of Ulk1

Joungmok Kim et al.

NATURE CELL BIOLOGY (2011)

Article Endocrinology & Metabolism

Melatonin reduces LH, 17 beta-estradiol and induces differential regulation of sex steroid receptors in reproductive tissues during rat ovulation

Luiz Gustavo A. Chuffa et al.

REPRODUCTIVE BIOLOGY AND ENDOCRINOLOGY (2011)

Review Biochemistry & Molecular Biology

Biology of progesterone action during pregnancy recognition and maintenance of pregnancy

TE Spencer et al.

FRONTIERS IN BIOSCIENCE-LANDMARK (2002)