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Chemistry, Analytical
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Summary: Microfluidic paper-based analytical devices (microPADs) are a promising platform for point-of-care assays. This study evaluated and compared 33 chromogenic substrate solutions for horseradish peroxidase (HRP) in terms of their analytical performance. The results showed that TMB and OPD substrates achieved the best overall performance. The findings of this study will guide the selection and formulation of substrate solutions for future paper-based assays involving HRP.
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Summary: This study presents the development of a 3D origami microfluidic paper-based analytical device (3D mu PAD) for the determination of iodide and iodate in edible seaweeds by colorimetric detection using a smartphone. The addition of a methacrylate holder improved the interlayer contact in 3D mu PADs, resulting in enhanced sensitivity and precision, as well as real-time monitoring. The assay relies on the formation of a blue triiodide-starch complex at the detection areas of the 3D mu PAD, providing an affordable, fast, and environmentally friendly method for simultaneous determination of inorganic iodine species. Under optimal conditions, the method achieved low limits of detection and quantification for iodide and iodate.
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Zhiyin Yu et al.
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Wai Cheung Chan et al.
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Xia Tong et al.
Summary: A cascade reaction system integrated with threaded 3D microfluidic paper analytical device (3D mu PAD) was developed for background-free and visual detection of organophosphorus pesticides (OPs) in agricultural samples. The system utilized a cascade reaction mechanism involving the hydrolysis of acetylcholine by butyrylcholinesterase (BChE), the reduction of MnO2 nanosheets, and the oxidation of o-phenylenediamine. The detection platform showed accurate response, facile operation, and background-free detection, providing a new alternative approach for on-site pesticide detection.
BIOSENSORS & BIOELECTRONICS
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Review
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Changyu Cao et al.
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Chemistry, Inorganic & Nuclear
Reddicherla Umapathi et al.
Summary: Due to over application of synthetic pesticides, pesticide residues pose an increasing threat to ecosystems and human health. Electrochemical sensor and biosensor platforms have emerged as powerful analytical methods for detecting pesticide residues, offering advantages such as synergistic aspects, systematic fabrication procedure, ease of detection, sensitivity, and selectivity. Additionally, portable electrochemical devices have been developed for on-site detection of pesticide residues.
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Zahra Shojaeifard et al.
Summary: A novel method has been developed for immobilizing hydrophilic indicators on the surface of paper-based strips in aqueous solution. The method utilizes a hydrophobic deep eutectic solvent (DES) to immobilize the indicators without the need for hydrophobic barriers. The resulting colorimetric strip demonstrates homogeneous color, reversibility, and significant leaching stability over months.
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Abderrahman Lamaoui et al.
Summary: In this work, a paper-based analytical device (PAD) utilizing molecularly imprinted polymer (MIP) as the biomimetic receptor and a simple colorimetric assay combined with smartphone readout was developed. The device showed high sensitivity and long-term stability, making it applicable for real-time colorimetric assays in environmental monitoring, public health, and food control.
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Songtao Dong et al.
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Ming Mu et al.
Summary: This review systematically presents the recent development of fabrication, properties, and applications of nanozyme-SERS systems. The fundamentals of nanozymes and SERS technique are introduced, followed by the classification of nanozyme-SERS systems. The influence factors on the properties of nanozyme-SERS systems and their applications in various fields are discussed. The challenges and perspectives to construct new nanozyme-SERS systems are also emphasized.
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Miriam Daniel et al.
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Yu Wang et al.
Summary: Alzheimer's disease is a common neurodegenerative disease, and the conventional methods for detecting the activity of acetylcholinesterase (AChE) are not patient-friendly. In this study, 2D Zn-TCPP(Fe) nanosheets were used as a catalyst for a colorimetric assay to measure AChE activity in a convenient and rapid manner. The proposed method showed high selectivity and sensitivity, making it a potential alternative for early diagnosis and drug screening of Alzheimer's disease.
ANALYTICAL CHEMISTRY
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Ge Kang et al.
Summary: The study demonstrates the exceptional oxidase-like activity of single-atom Pt catalysts, which enhances the generation of H2O2 and 1O2 species, facilitating the chromogenic reaction. Based on this, a novel colorimetric assay for α-Glu is designed and successfully applied to serum samples, showing excellent analytical performance.
CHEMICAL ENGINEERING JOURNAL
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Chemistry, Multidisciplinary
Zhihui Mao et al.
Summary: By mimicking active catalytic sites of natural enzymes and combining them with distinct channels of metal organic frameworks, an active copper mimetic oxidase enzyme (Cu-MOF) was designed and synthesized with good structure and clear catalytic sites, showing excellent oxidase-like activity and antibacterial efficacy.
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Chemistry, Analytical
Abderrahman Lamaoui et al.
Summary: The study developed a paper-based MIP-PAD utilizing MIP as the receptor for simple colorimetric assay, offering a platform for real-time, selective, rapid, and low-cost environmental monitoring and food control.
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Parham Taslimi et al.
Summary: Sulfonamide derivatives have a wide range of biological activities and potential as medical molecules in drug development. Studies have shown that these compounds have an impact on various enzymes. The synthesized derivatives demonstrate inhibitory effects on AChE, GST, and α-GLY enzymes, with stronger inhibition observed at lower concentrations through the addition of functional electronegative groups.
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Yunyi Zhang et al.
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Younhee Kang et al.
Summary: The study identified that nurses caring for dementia patients face significant workloads and mental stress, in addition to difficulties in playing a mediator role and lack of systematic support. To reduce the burden on nurses, supportive measures tailored to their occupational characteristics should be developed based on workload estimates that consider the unique attributes of dementia patients.
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Summary: A fluorescence-colorimetric dual-signal biosensor was developed for monitoring organophosphorus pesticides by encapsulating AuNCs in a metal-organic framework. This biosensor combines fluorescence and colorimetric signals based on the enzymolysis product of AChE and CHO, allowing detection through the inhibition of AChE activity. Additionally, colorimetric paper strips and a smartphone APP were utilized for visual semiquantitative detection and real-time supervision of pesticide contamination.
ANALYTICAL CHEMISTRY
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Xia Tong et al.
Summary: A new strategy based on dual-emission carbon dots has been developed for simultaneous monitoring of GGT and ALP activity, showing high sensitivity and wide linear ranges. Detection of GGT and ALP activity can be achieved through IFE and SQE of blue and red channels of CDs, meeting the monitoring needs in human serum samples.
ANALYTICA CHIMICA ACTA
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Eka Noviana et al.
Summary: Microfluidic paper-based analytical devices (muPADs) have gained significant interest as a promising analytical platform in the past decade, offering unique advantages over traditional microfluidics. This comprehensive Review highlights fabrication methods, device designs, and detection strategies, as well as the growing applications of muPADs, while discussing the field's need for further advancement to realize its full potential.
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Dong-Mei Liu et al.
Summary: Acetylcholinesterase (AChE) is widely used in biological and chemical sensors, assisting in the treatment of neurodegenerative diseases and detection of pesticides and heavy metals; Colorimetric method is a popular strategy for AChE assay, known for its low cost, practicality, and simplicity.
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