Journal
BIRTH DEFECTS RESEARCH
Volume -, Issue -, Pages -Publisher
WILEY
DOI: 10.1002/bdr2.2280
Keywords
conventional autopsy; MIA; PMMR; post-mortem magnetic resonance imaging; targeted organ biopsy
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This study assesses the feasibility and accuracy of minimally invasive autopsy (MIA) compared to conventional autopsy and found that there was a 97.3% concordance in diagnostic accuracy between MIA and autopsy in malformed cases. The overall diagnostic accuracy of MIA was 96.04%.
Background: Minimally invasive autopsy (MIA) using post-mortem magnetic resonance imaging with ancillary investigations is reported as accurate as conventional autopsy. This study assesses MIA's feasibility and accuracy compared to conventional autopsy.Method: MIA and/or conventional autopsy were performed on malformed fetuses (14-20 weeks gestation) and stillbirths (>20 weeks gestation), with/without malformation. Concordance in diagnostic accuracy (95% confidence interval [CI]) and agreement (Kappa coefficient [k]) were assessed in malformed cases where both MIA and autopsy were conducted.Results: We enrolled 200 cases, including 100 malformed fetuses (<20 weeks) and 100 stillbirths (with/without malformations). Concordance of 97.3% was observed between MIA and autopsy in 156 malformed cases. The overall diagnostic accuracy of MIA was 96.04%.Conclusion: While conventional autopsy remains the gold standard, MIA is feasible in tertiary care settings. It can be considered a potential alternative for post-mortem assessment, particularly in settings with limited facility of conventional autopsy and parental refusal.
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