☆ 4.6 Article

Transparent silk fibroin film-facilitated infected-wound healing through antibacterial, improved fibroblast adhesion and immune modulation

JOURNAL OF MATERIALS CHEMISTRY B (2024)

Related references

Note: Only part of the references are listed.

Article Chemistry, Multidisciplinary

Bioinspired Polyacrylic Acid-Based Dressing: Wet Adhesive, Self-Healing, and Multi-Biofunctional Coacervate Hydrogel Accelerates Wound Healing

Lingshuang Wang et al.

Summary: Polyacrylic acid (PAA) and its derivatives are commonly used as matrices in wound dressings, but their weak wet adhesion limits their clinical application. In this study, a PAA-based coacervate hydrogel with strong wet adhesion capability is created by mixing PAA copolymers with isoprenyl oxy poly(ethylene glycol) ether and tannic acid. The coacervate exhibits solid adhesion to both dry and wet substrates, with an adhesive strength to skin of 23.4 kPa and 70% adhesion underwater. It also possesses desirable self-healing and extensible properties, making it suitable for joints that undergo frequent movement. The coacervate demonstrates antibacterial activity, facilitates fibroblast migration, modulates macrophage polarization, shortens hemostatic time, and promotes collagen deposition, angiogenesis, and epithelialization, suggesting its promising potential as a wound dressing in medical translation.

ADVANCED SCIENCE (2023)

Add to Collection

Review Pharmacology & Pharmacy

Delivering on the promise of recombinant silk-inspired proteins for drug delivery

Constancio Gonzalez-Obeso et al.

Summary: Effective drug delivery is crucial for successful medical treatment. Silks and recombinant silks have emerged as preferred polymeric drug delivery systems due to their unique properties and tailored physicochemical characteristics.

ADVANCED DRUG DELIVERY REVIEWS (2023)

Add to Collection

Article Materials Science, Multidisciplinary

Synthesis of a Reactive Oxygen Species Responsive Star Polymer for the Controlled Release of Carbendazim

Yan Qin et al.

Summary: An intelligent responsive pesticide delivery system with ROS responsive star polymer micellar slow-release system shows great potential in improving the utilization rate of pesticides in agriculture. The system successfully loaded MBC and demonstrated a 1.64-fold increase in release amount with the presence of H2O2. It also exhibited a high inhibitory rate against R. solani. This study highlights the importance of designing pesticide vectors according to the target environment for crop protection, improved pesticide utilization, and environmental preservation.

ACS APPLIED POLYMER MATERIALS (2023)

Add to Collection

Article Chemistry, Physical

Redox-responsive microemulsion: Fabrication and application to curcumin encapsulation

Yongmin Zhang et al.

Summary: By investigating the hydrophilicity change of a selenium-containing alcohol and its effect on the stability of microemulsions, it was found that the redox reaction of this selenium-containing alcohol can efficiently switch the stability of microemulsions, providing a new nanoplatform for the delivery of bioactive substances.

JOURNAL OF COLLOID AND INTERFACE SCIENCE (2023)

Add to Collection

Article Chemistry, Multidisciplinary

CO enhances agomir transfection under pathological conditions to inhibit MMP overexpression

Xin Jin et al.

Summary: CO can reactivate uptake of agomir in pathological conditions via RAB5-mediated endocytic pathway, and a responsive nanoparticle-crosslinked injectable hydrogel (CO-Ago gel) was designed to co-deliver CO and Ago to inhibit MMP overexpression. Compared to a typical matrix-enhanced gene therapy (Ago gel), CO-Ago gel significantly improved the uptake of Ago, achieving a several-fold enhancement of targeted gene expression under pathological conditions. The therapeutic effect of CO-Ago gel on MMP overexpression was assessed in rat models of myocardial ischemia reperfusion and diabetic skin wound healing, suggesting its potential in gene-based therapies and vaccines in vivo.

NANO TODAY (2023)

Add to Collection

Article Engineering, Biomedical

Atmosphere-inspired multilayered nanoarmor with modulable protection and delivery of Interleukin-4 for inflammatory microenvironment modulation

Xin Ge et al.

Summary: This study successfully delivered interleukin-4 (IL-4) into the inflammatory microenvironment by constructing a multilayered protective nanoarmor, which enabled M2 macrophage polarization and downregulation of inflammatory mediators for the treatment of inflammatory bowel disease (IBD). Additionally, the system improved gut microbiota dysbiosis, inhibited inflammation, and promoted colitis tissue repair.

BIOMATERIALS (2023)

Add to Collection

Article Materials Science, Multidisciplinary

Directly self-assembling method to easily prepare rough silk fibroin film

Guotao Cheng et al.

Summary: The surface roughness of silk fibroin biomaterials affects cell adhesion and growth, and a silk fibroin film with rough surfaces can promote cell adhesion and growth due to the self-assembly of silk fibroin molecules.

SOFT MATERIALS (2022)

Add to Collection

Article Chemistry, Multidisciplinary

Self-Bonded Hydrogel Inverse Opal Particles as Sprayed Flexible Patch for Wound Healing

Li Wang et al.

Summary: Self-bonded hydrogel particles, achieved through photothermal conversion and phase change, offer a solution for wound healing and drug delivery monitoring.

ACS NANO (2022)

Add to Collection

Article Engineering, Environmental

Bio-adhesive catechol-modified chitosan wound healing hydrogel dressings through glow discharge plasma technique

Chengyuan Sun et al.

Summary: The study successfully prepared CS-GA hydrogels with excellent antioxidant properties and confirmed their ability to form cross-linked hydrogels under physiological conditions, as well as their potential applications in wound healing and hemostasis.

CHEMICAL ENGINEERING JOURNAL (2022)

Add to Collection

Article Chemistry, Multidisciplinary

Sensitive Activatable Nanoprobes for Real-Time Ratiometric Magnetic Resonance Imaging of Reactive Oxygen Species and Ameliorating Inflammation In Vivo

Xilan Li et al.

Summary: A novel nanotheranostic agent, TMSN@PM, coated with platelet membrane and mesoporous silica nanoparticles, was developed for targeted imaging and treatment of inflammatory diseases. The agent can scavenge excess reactive oxygen species and enhance magnetic resonance imaging under inflammatory conditions. This non-invasive imaging-based strategy provides early prediction of therapeutic outcomes in inflammatory therapy.

ADVANCED MATERIALS (2022)

Add to Collection

Article Engineering, Biomedical

Oral nanotherapeutics based on Antheraea pernyi silk fibroin for synergistic treatment of ulcerative colitis

Ya Ma et al.

Summary: This study developed engineered Antheraea pernyi silk fibroin nanoparticles loaded with an anti-inflammatory drug, resveratrol, to target colonic epithelial cells and macrophages for effective ulcerative colitis (UC) treatment. The nanoparticles showed lysosomal escape capacity, pH and reactive oxygen species responsiveness, and targeted delivery to the cytoplasm for on-demand drug release. Oral treatment with these nanoparticles relieved UC symptoms by restoring damaged colonic epithelial barriers, reducing inflammation, and rebalancing intestinal microbiota.

BIOMATERIALS (2022)

Add to Collection

Article Engineering, Biomedical

Promoting Re-epithelialization in an oxidative diabetic wound microenvironment using self-assembly of a ROS-responsive polymer and P311 peptide micelles

Rong Shi et al.

Summary: P311-loaded micelles synthesized by self-assembly have the ability to transform oxidative wound microenvironment into a proregenerative one and provide cues for epidermal cell migration, resulting in accelerated healing of diabetic wounds.

ACTA BIOMATERIALIA (2022)

Add to Collection

Article Biochemistry & Molecular Biology

Preparation of Highly Crystalline Silk Nanofibrils and Their Use in the Improvement of the Mechanical Properties of Silk Films

Ji Hye Lee et al.

Summary: In this study, a highly crystalline silk fibril was successfully extracted from silk by combining degumming with ultrasonication. The addition of silk nanofibrils remarkably improved the mechanical properties of the RSF film.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2022)

Add to Collection

Article Engineering, Biomedical

Flat Silk Cocoon-Based Dressing: Daylight-Driven Rechargeable Antibacterial Membranes Accelerate Infected Wound Healing

Shixiong Yi et al.

Summary: Bacterial infection is one of the leading causes of death globally. The prevalence of infections from antibiotic-resistant bacteria has been increasing, leading to an urgent need for innovative antibacterial wound dressings. Researchers have found that g-C3N4-based flat silk cocoons with rechargeable antibacterial activity can efficiently generate reactive oxygen species (ROS) under daylight irradiation and release them in the dark. These materials exhibit good biocompatibility, strong mechanical characteristics, and excellent bactericidal efficiency, promoting faster wound healing and reducing bacterial infections in a rat model.

ADVANCED HEALTHCARE MATERIALS (2022)

Add to Collection

Article Engineering, Environmental

Synergistic effect of highly aligned bacterial cellulose/gelatin membranes and electrical stimulation on directional cell migration for accelerated wound healing

Li Wang et al.

Summary: Directional cell migration plays a critical role in wound healing. Combining ordered topography and electric field stimulation is a promising therapeutic strategy to guide cell migration for improved wound healing.

CHEMICAL ENGINEERING JOURNAL (2021)

Add to Collection

Article Materials Science, Textiles

Tuning the Mechanical Properties of Silkworm Silk Fibres by Thermally Induced Modification of Crystalline Nanostructure

Shan Du et al.

Summary: This study investigates the nanocrystalline structures of Antheraea pernyi and Bombyx mori silk fibres through thermal treatment, revealing the impact of structure on the mechanical properties of the fibres. It demonstrates how an increase in temperature leads to changes in intramolecular beta-sheet, crystallinity, and crystallite size, resulting in variations in modulus, hardness, and tensile strength. The findings provide insights into how size effects can be utilized to create bioinspired materials with adjustable mechanical properties.

FIBERS AND POLYMERS (2021)

Add to Collection

Article Chemistry, Inorganic & Nuclear

Biofabrication and characterization of AgNPs synthesized by Justicia adhatoda and efficiency on multi-drug resistant microbes and anticancer activity

Mathiyazhagan Narayanan et al.

Summary: The methanol leaf extract of Justicia adhatoda has the potential to synthesize silver nanoparticles, which exhibit remarkable antimicrobial activities against multi-drug resistant bacteria and fungi, as well as significant anticancer activity against cervical cancer cells. This suggests a promising biomedical application for the biofabricated nanoparticles.

INORGANIC CHEMISTRY COMMUNICATIONS (2021)

Add to Collection

Article Materials Science, Biomaterials

Bimetallic palladium@copper nanoparticles: Lethal effect on the gram-negative bacterium Pseudomonas aeruginosa

Xue Huang et al.

Summary: By synthesizing small palladium@copper (Pd1.9Cu) alloy nanoparticles, successful sterilization of Pseudomonas aeruginosa was achieved, displaying a more powerful bactericidal effect. These nanoparticles also triggered the burst of intracellular reactive oxygen species generation and accelerated ion release, enhancing the therapeutic effect against P. aeruginosa infection.

MATERIALS SCIENCE & ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS (2021)

Add to Collection

Article Engineering, Biomedical

A physicochemical double cross-linked multifunctional hydrogel for dynamic burn wound healing: shape adaptability, injectable self-healing property and enhanced adhesion

Yang Yuan et al.

Summary: A novel double cross-linked hydrogel prepared by Schiff base and catechol-Fe3+ chelation bond was designed for dynamic burn wounds, showing enhanced physicochemical properties and efficacy, suitable for wounds with irregular shapes.

BIOMATERIALS (2021)

Add to Collection

Article Multidisciplinary Sciences

Regulation of macrophage polarization through surface topography design to facilitate implant-to-bone osteointegration

Yizhou Zhu et al.

Summary: The study showed that reducing the scale of honeycomb-like TiO2 structures can activate anti-inflammatory macrophage phenotype, promoting osteogenesis. Among different scales, the 90-nanometer sample demonstrated the most effective outcomes in both in vitro cell culture and in vivo implantation experiments.

SCIENCE ADVANCES (2021)

Add to Collection

Article Nanoscience & Nanotechnology

Inflammation-Responsive Drug-Loaded Hydrogels with Sequential Hemostasis, Antibacterial, and Anti-Inflammatory Behavior for Chronically Infected Diabetic Wound Treatment

Yu Wang et al.

Summary: The study synthesized a dual-responsive hydrogel (pH and ROS) for drug release under inflammatory stimulation. This novel design retained dynamic functions of hydrogels and achieved sequential and on-demand drug delivery at diabetic-infected wound sites.

ACS APPLIED MATERIALS & INTERFACES (2021)

Add to Collection

Review Chemistry, Multidisciplinary

Functional Hydrogels as Wound Dressing to Enhance Wound Healing

Yongping Liang et al.

Summary: Hydrogels have shown promising advantages as wound dressings due to their excellent biochemical and mechanical properties. This review summarizes the advanced functions of hydrogel dressings, such as antimicrobial, adhesion, hemostasis, anti-inflammatory, substance delivery, self-healing, stimulus response, and conductivity, as well as the emerging wound monitoring feature. The potential applications for different types of wounds, including chronic wounds and focus on infected, burn, and diabetic wounds, are discussed, along with proposed future directions for hydrogel wound dressings in wound healing.

ACS NANO (2021)

Add to Collection

Article Biochemistry & Molecular Biology

Sustained Release of Insulin-Like Growth Factor-1 from Bombyx mori L. Silk Fibroin Delivery for Diabetic Wound Therapy

Meng-Jin Lin et al.

Summary: The study developed a high purity patented silk fibroin film for slow-release of insulin-like growth factor-1 (IGF-1), showing potential for diabetic wound therapy. The results indicate that the IGF-1-loaded SF films accelerated wound healing significantly by continuously activating the IGF1R pathway.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2021)

Add to Collection

Article Multidisciplinary Sciences

Sustained oxygenation accelerates diabetic wound healing by promoting epithelialization and angiogenesis and decreasing inflammation

Ya Guan et al.

Summary: The study developed a sustained oxygenation system using oxygen-release microspheres and a reactive oxygen species (ROS)-scavenging hydrogel to promote diabetic wound healing. The sustained release of oxygen enhanced cell survival and migration, angiogenic growth factor expression, angiogenesis, and decreased proinflammatory cytokine expression in diabetic wounds, leading to a significant increase in wound closure rate.

SCIENCE ADVANCES (2021)

Add to Collection

Article Chemistry, Multidisciplinary

A Novel Double-Crosslinking-Double-Network Design for Injectable Hydrogels with Enhanced Tissue Adhesion and Antibacterial Capability for Wound Treatment

Lei Wang et al.

ADVANCED FUNCTIONAL MATERIALS (2020)

Add to Collection

Review Pharmacology & Pharmacy

Molecular basis of bacterial disinfectant resistance

Samantha Mc Carlie et al.

DRUG RESISTANCE UPDATES (2020)

Add to Collection

Article Pharmacology & Pharmacy

Improved solubility, dissolution, and oral bioavailability for atorvastatin-Pluronic® solid dispersions

Mohamed A. Shaker et al.

INTERNATIONAL JOURNAL OF PHARMACEUTICS (2020)

Add to Collection

Article Chemistry, Multidisciplinary

Injectable Polypeptide-Protein Hydrogels for Promoting Infected Wound Healing

Liang Cheng et al.

ADVANCED FUNCTIONAL MATERIALS (2020)

Add to Collection

Article Chemistry, Multidisciplinary

A Macroporous Hydrogel Dressing with Enhanced Antibacterial and Anti-Inflammatory Capabilities for Accelerated Wound Healing

Wen-Can Huang et al.

ADVANCED FUNCTIONAL MATERIALS (2020)

Add to Collection

Article Materials Science, Textiles

Physicochemical and Antibacterial Characterization of Nanofibrous Wound Dressing from Silk Fibroin-polyvinyl Alcohol- Elaeagnus Angustifolia Extract

Jhamak Nourmohammadi et al.

FIBERS AND POLYMERS (2020)

Add to Collection

Article Pharmacology & Pharmacy

Long-Term Toxicity Study of Topical Administration of a Highly-Stable rh-aFGF Carbomer 940 Hydrogel in a Rabbit Skin Wound Model

Li Zhang et al.

FRONTIERS IN PHARMACOLOGY (2020)

Add to Collection

Article Chemistry, Multidisciplinary

Spatial Distribution of PEO-PPO-PEO Block Copolymer and PEO Homopolymer in Lipid Bilayers

Mihee Kim et al.

LANGMUIR (2020)

Add to Collection

Article Multidisciplinary Sciences

Dissolved oxygen from microalgae-gel patch promotes chronic wound healing in diabetes

Huanhuan Chen et al.

SCIENCE ADVANCES (2020)

Add to Collection

Article Biochemistry & Molecular Biology

Manufacture of pH- and HAase-responsive hydrogels with on-demand and continuous antibacterial activity for full-thickness wound healing

Shengcan Guan et al.

INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES (2020)

Add to Collection

Article Engineering, Biomedical

Improving mechanical and antibacterial properties of PMMA via polyblend electrospinning with silk fibroin and polyethyleneimine towards dental applications

Ugur Yunus Karatepe et al.

BIOACTIVE MATERIALS (2020)

Add to Collection

Article Instruments & Instrumentation

Pluronic-F127 composite film loaded with erythromycin for wound application: formulation, physicomechanical and in vitro evaluations

Taradokht Alavi et al.

DRUG DELIVERY AND TRANSLATIONAL RESEARCH (2019)

Add to Collection

Article Medicine, Research & Experimental

Nanofiber Dressings Topically Delivering Molecularly Engineered Human Cathelicidin Peptides for the Treatment of Biofilms in Chronic Wounds

Yajuan Su et al.

MOLECULAR PHARMACEUTICS (2019)

Add to Collection

Article Biophysics

Antibacterial silk fibroin scaffolds with green synthesized silver nanoparticles for osteoblast proliferation and human mesenchymal stem cell differentiation

Smita Patil et al.

COLLOIDS AND SURFACES B-BIOINTERFACES (2019)

Add to Collection

Article Materials Science, Multidisciplinary

Biocompatible, small-sized and well-dispersed gold nanoparticles regulated by silk fibroin fiber from Bombyx mori cocoons

Chengzhi Yang et al.

FRONTIERS OF MATERIALS SCIENCE (2019)

Add to Collection

Article Nanoscience & Nanotechnology

Polydopamine-Coated Antheraea pernyi (A. pernyi) Silk Fibroin Films Promote Cell Adhesion and Wound Healing in Skin Tissue Repair

Jie Wang et al.

ACS APPLIED MATERIALS & INTERFACES (2019)

Add to Collection

Article Biochemistry & Molecular Biology

Folate-conjugated pluronic/polylactic acid polymersomes for oral delivery of paclitaxel

Xiao Qian Pan et al.

INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES (2019)

Add to Collection

Article Chemistry, Physical

Fabrication and Characterization of Silk Fibroin/Curcumin Sustained-Release Film

Xiaoning Zhang et al.

MATERIALS (2019)

Add to Collection

Article Biochemistry & Molecular Biology

Production and characterization of electrospun silk fibroin based asymmetric membranes for wound dressing applications

Sonia P. Miguel et al.

INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES (2019)

Add to Collection

Article Chemistry, Multidisciplinary

Bioinspired Multifunctional Hybrid Hydrogel Promotes Wound Healing

Guopu Chen et al.

ADVANCED FUNCTIONAL MATERIALS (2018)

Add to Collection

Review Pharmacology & Pharmacy

Tissue-specific Regulation of Innate Immune Responses by Human Cathelicidin LL-37

Panjit Chieosilapatham et al.

CURRENT PHARMACEUTICAL DESIGN (2018)

Add to Collection

Article Biochemistry & Molecular Biology

Hydroxyethyl cellulose hydrogel for wound dressing: Fabrication, characterization and in vitro evaluation

Gomaa F. El Fawal et al.

INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES (2018)

Add to Collection

Article Engineering, Biomedical

Silk fibroin/chitosan thin film promotes osteogenic and adipogenic differentiation of rat bone marrow-derived mesenchymal stem cells

Da-Wei Li et al.

JOURNAL OF BIOMATERIALS APPLICATIONS (2018)

Add to Collection

Review Anatomy & Morphology

Preparation of Silk Fibroin Carriers for Controlled Release

Qiang Liu et al.

MICROSCOPY RESEARCH AND TECHNIQUE (2017)

Add to Collection

Article Biochemistry & Molecular Biology

Enhancement of curcumin wound healing ability by complexation with 2-hydroxypropyl-γ-cyclodextrin in sacran hydrogel film

Nasrul Wathoni et al.

INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES (2017)

Add to Collection

Article Biochemistry & Molecular Biology

Quercetin loading CdSe/ZnS nanoparticles as efficient antibacterial and anticancer materials

Xiaofang Yang et al.

JOURNAL OF INORGANIC BIOCHEMISTRY (2017)

Add to Collection

Review Polymer Science

Poloxamers, poloxamines and polymeric micelles: Definition, structure and therapeutic applications in cancer

Mauro Almeida et al.

JOURNAL OF POLYMER RESEARCH (2017)

Add to Collection

Article Chemistry, Medicinal

Individual and Combined Effects of Engineered Peptides and Antibiotics on Pseudomonas aeruginosa Biofilms

Biswajit Mishra et al.

PHARMACEUTICALS (2017)

Add to Collection

Review Pharmacology & Pharmacy

Curcumin and its topical formulations for wound healing applications

Chandana Mohanty et al.

DRUG DISCOVERY TODAY (2017)

Add to Collection

Article Nanoscience & Nanotechnology

Transcriptome Analysis Reveals Silver Nanoparticle-Decorated Quercetin Antibacterial Molecular Mechanism

Dongdong Sun et al.

ACS APPLIED MATERIALS & INTERFACES (2017)

Add to Collection

Article Gastroenterology & Hepatology

The challenges of multi-drug-resistance in hepatology

Javier Fernandez et al.

JOURNAL OF HEPATOLOGY (2016)

Add to Collection

Review Pharmacology & Pharmacy

Injectable In Situ Forming Microparticles: A Novel Drug Delivery System

Evren Algin Yapar et al.

TROPICAL JOURNAL OF PHARMACEUTICAL RESEARCH (2012)

Add to Collection

Article Biochemistry & Molecular Biology

Regulation of Silk Material Structure by Temperature-Controlled Water Vapor Annealing

Xiao Hu et al.

BIOMACROMOLECULES (2011)

Add to Collection

Article Engineering, Biomedical

Mechanism of enzymatic degradation of beta-sheet crystals

Keiji Numata et al.

BIOMATERIALS (2010)

Add to Collection

Review Biochemistry & Molecular Biology

Function and regulation of AP-1 subunits in skin physiology and pathology

P Angel et al.

ONCOGENE (2001)

Add to Collection

© Peeref 2019-2024. All rights reserved.