Journal
CNS & NEUROLOGICAL DISORDERS-DRUG TARGETS
Volume 14, Issue 3, Pages 304-308Publisher
BENTHAM SCIENCE PUBL
DOI: 10.2174/1871527314666150123122851
Keywords
Antidepressant; glucocorticoid; microglia; norepinephrine; stress
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Psychological stress leads to activation and proliferation of microglial cells in different brain regions. These effects are mediated by inflammatory cytokines, as well as stress hormones including glucocorticoids and norepinephrine. Eliminating microglia from the nervous system or blocking their activation prevented the stress-induced impairments on brain cognitive functions. We conclude that microglial cells are important meditators underlying anti-depression therapies.
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