Related references
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Article
Pharmacology & Pharmacy
Mohamed U. Nooman et al.
Summary: This study demonstrated that the SLs produced by microbial conversion of Moringa oleifera oil cake significantly reduced oxidative stress, inflammation, and apoptotic markers in rats with AA-induced UC, similar to the reference sulfasalazine.
JOURNAL OF PHARMACY AND PHARMACOLOGY
(2023)
Review
Chemistry, Physical
Srija Pal et al.
Summary: Sophorolipids are surface-active glycolipids produced by non-pathogenic yeast species and have extensive industrial applications due to their unique physicochemical properties. Compared to chemically synthesized surfactants, sophorolipids are less toxic, more environmentally friendly, biodegradable, and exhibit robustness for industrial applications. They also possess low critical micelle concentrations, reduced interfacial surface tension, and the ability to dissolve non-polar components. The article highlights the utilization of these properties, discusses the advantages and disadvantages of sophorolipids, and explores their potential commercial applications in real-world scenarios. The review also compares biosurfactants with man-made equivalents and provides insights for manufacturing natural or green surfactants with innovative qualities.
ADVANCES IN COLLOID AND INTERFACE SCIENCE
(2023)
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Chemistry, Applied
Fernando Rivero-Pino
Summary: New challenges in food production and processing are emerging due to the growing global population and the need for a sustainable food system. Bioactive peptides derived from food proteins have potential preventive and therapeutic applications for various diseases. Extensive research has been conducted on the bioactivity of protein hydrolysates, particularly through in vitro tests, and some studies have examined their efficacy in animal models and human subjects. However, there is limited published literature on the functionality and effects of processing, storage, and gastrointestinal digestion on the bioactivity of these peptides in food matrices. This review aims to summarize the existing literature on protein hydrolysates as functional ingredients, including their processing, storage, and simulated gastrointestinal digestion, and their impact on the bioactivity of these peptides.
Article
Materials Science, Biomaterials
Sahadevan Seena et al.
Summary: The combination of acidic sophorolipid nanoparticles (ASL NPs) and LL37 peptides demonstrates an effective antimicrobial effect against various bacteria in the presence of human serum and trypsin. It also prevents the formation of Staphylococcus aureus biofilm and eradicates existing biofilm. The combination has a rapid damaging effect on the bacterial membrane, particularly on Escherichia coli, and is biocompatible to human keratinocyte cells and human umbilical vein endothelial cells.
BIOMATERIALS ADVANCES
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Article
Biotechnology & Applied Microbiology
Amr S. Al-kashef et al.
Summary: This study demonstrates the economic production of sophorolipids (SLs) from potato peels waste and frying oil waste, and their effect against mucormycetes fungi. The highest SLs yield was obtained from Candida parapsilosis, showing high inhibition efficiency against mucormycetes fungi.
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Esther Molina-Penate et al.
Summary: Alternative production processes using waste are necessary for resource conservation and preventing material scarcity. This study proposes a method of valorizing the residual solid fraction from enzymatic hydrolysis of biowaste using solid-state fermentation. Two digestates from anaerobic digestion processes were used as cosubstrates to modify the pH and promote bacterial growth. The final product contained spores and crystal proteins with insecticidal activity, allowing for the sustainable use of all materials liberated during the enzymatic hydrolysis.
Article
Engineering, Environmental
Golafarin Ghoreishi et al.
Summary: This study aims to investigate the feasibility of using green waste to produce a biostimulant (IAA) and biopesticide (conidial spore) through solid-state fermentation. Trichoderma harzianum was selected as the inoculum and the green waste was a mixture of grass clippings and pruning waste. The results showed that washing and using phosphate buffer had a positive effect on the quality and bioproduction of the green waste.
Article
Biotechnology & Applied Microbiology
Simms A. Adu et al.
Summary: This study compares the effects of microbial glycolipids and synthetic surfactant SLES on human keratinocyte cells. The results show that microbial glycolipids have different effects on the cells depending on their chemical structure. Acidic sophorolipids and mono-rhamnolipids have minimal effects on cell viability and morphology, while di-rhamnolipids can reduce inflammation and increase the production of immune factors.
APPLIED MICROBIOLOGY AND BIOTECHNOLOGY
(2023)
Review
Chemistry, Multidisciplinary
Vaishnavi S. Nagtode et al.
Summary: Surfactants, being amphiphilic molecules, are crucial in various industries such as agriculture, medicine, personal care, food, and petroleum. Traditional surfactants derived from petroleum not only lead to petroleum pollution but also cause environmental damage. Therefore, newer techniques involving biosurfactants of microbial or plant origins have been suggested for their advantages in terms of biodegradability, toxicity, raw material availability, and applicability. This review focuses on the advantages of biosurfactants over synthetic surfactants and explores their potential applications, market aspects, and future directions.
Article
Biotechnology & Applied Microbiology
Benjamin Ingham et al.
Summary: Conventional food-grade feedstocks for sophorolipid production can have negative impacts on food supply and commodity prices. A screening platform was applied to customize the fermentation media composition and mitigate inhibitory by-products, using predictive modelling and different preparation methods such as tangential flow filtration or autoclaving.
BIOCHEMICAL ENGINEERING JOURNAL
(2023)
Article
Agricultural Engineering
Ming Ho To et al.
Summary: Large scale food waste was analyzed to determine the concentration of potential inhibitors, and lactic acid, acetic acid, and ethanol were identified as inhibitors of the growth of S. bombicola and its SLs production. Various methods were evaluated to remove these inhibitors, and a simple and effective strategy for removing inhibitors from food waste was developed, complying with the 12 principles of green chemistry and suitable for industrial high SLs production.
BIORESOURCE TECHNOLOGY
(2023)
Review
Biotechnology & Applied Microbiology
Eugenia Leandro Almeida et al.
Summary: Biodiesel, a substitute for petrochemical diesel, can be obtained from renewable raw materials. However, its production leads to a market saturation of glycerol, causing devaluation and economic unfeasibility. Despite this, research explores the use of glycerol as a raw material for biofuel production, driven by environmental concerns.
FERMENTATION-BASEL
(2023)
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Agricultural Engineering
Muneer Ahmed Qazi et al.
Summary: Sophorolipids are highly active green surfactants appreciated worldwide for their low toxicity, biodegradability, wide range of applications, and biotechnological potential. The oleaginous budding yeast Starmerella bombicola is the main producer of sophorolipids using low-cost substrates. Genetic engineering tools in S. bombicola offer possibilities to improve production titers, structural variability, and stability of sophorolipids. Advanced technologies like 'Omics and CRISPR/Cas have also contributed to rational engineering research.
BIORESOURCE TECHNOLOGY
(2022)
Article
Biochemical Research Methods
Yang Chen et al.
Summary: This study analyzed the sedimentation mechanism of Sophorolipids (SLs) and introduced ultrasonic enhanced sedimentation technology (UEST) to increase SLs productivity and yield, while reducing loss ratio. This provides a new horizon for optimizing the SLs fermentation process.
BIOTECHNOLOGY JOURNAL
(2022)
Article
Biotechnology & Applied Microbiology
Silke Claus et al.
Summary: In this study, we identified 254 putative transporter genes in the yeast Starmerella bombicola through computational analysis of its genome, and predicted potential substrates for each of them. The ATP Binding Cassette (ABC) transporter Superfamily, in particular, plays a crucial role in the highly efficient export of sophorolipids. Through deletion mutants, we confirmed the involvement of these transporters in the efflux of hydrophobic compounds, antibiotics, and sophorolipids, and discovered a second sophorolipid transporter located outside the biosynthetic gene cluster.
Article
Biotechnology & Applied Microbiology
Benjamin Ingham et al.
Summary: Sophorolipid biosurfactants require suitable media conditions to improve productivity and reduce production costs. A central composite design was applied to analyze the effects of altering glucose, rapeseed oil, corn steep liquor and ammonium sulphate concentrations on sophorolipid production. An optimum media composition was found, and a regression model was developed for substrate screening and process optimization.
MICROBIAL BIOTECHNOLOGY
(2022)
Review
Biotechnology & Applied Microbiology
Sven Dierickx et al.
Summary: Sophorolipids are bio-based compounds produced by specific organisms with mild and environmentally friendly characteristics, attracting interest from academia and industry. They are currently used in personal care and cleaning industries, with ongoing research in other fields. Significant progress has been made in production techniques, application research, and genetic engineering strategies.
BIOTECHNOLOGY ADVANCES
(2022)
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Energy & Fuels
Maria Martinez et al.
Summary: This study explores the production of SLs using sustainable resources and provides an economic evaluation of the solid-state fermentation process. The results highlight the significant impact of the physical properties of substrates and supports on process costs.
Article
Agriculture, Multidisciplinary
Talita de O. Caretta et al.
Summary: Results showed that sophorolipids inhibited the mycelial growth in vitro at a minimum concentration of 2 mg mL(-1). Applying sophorolipids at 1, 2, and 4 mg mL(-1) on tomato leaves before inoculation of B. cinerea was the most effective treatment, reducing leaf necrosis by up to 76.90%. Washing tomato fruits with sophorolipids before inoculation of B. cinerea could inhibit gray mold development by up to 96.27%.
JOURNAL OF THE SCIENCE OF FOOD AND AGRICULTURE
(2022)
Article
Agriculture, Dairy & Animal Science
Inkyung Park et al.
Summary: This study investigated the antimicrobial activity of sophorolipids (SLs) against various bacteria and their effects on growth and gut health in broiler chickens afflicted with necrotic enteritis. The results showed that SLs can inhibit bacterial growth, increase body weight and average daily gain in NE-infected broiler chickens, and improve their gut health.
Review
Biochemistry & Molecular Biology
T. Rebecca Miceli et al.
Summary: Sophorolipids (SLs) are biosurfactants synthesized by non-pathogenic microorganisms. They have the potential to provide low-cost therapeutics and possess anti-cancer activity against various cancer cell lines while showing lower cytotoxicity towards noncancerous cells. However, there are gaps and inconsistencies in the literature, and further research is needed to optimize the design of SLs for therapeutic use.
BIOORGANIC & MEDICINAL CHEMISTRY
(2022)
Review
Engineering, Chemical
Nicolas Oiza et al.
Summary: Solid-state fermentation is an important approach for producing value-added bioproducts from organic waste. It has the potential to use a wide variety of organic waste and plays a significant role in the circular bioeconomy. In addition to hydrolytic enzymes, solid-state fermentation has been extended to produce valuable products such as biosurfactants and biopesticides. However, challenges in scale-up and commercialization still exist.
Review
Biochemistry & Molecular Biology
Wei Yan Cho et al.
Summary: Sophorolipids, a well-known glycolipid biosurfactant, have promising applications in diverse areas such as food and health due to their high biodegradability and antimicrobial properties. They exhibit different biological and physicochemical properties based on their structural forms, making them attractive for use in the food and health sectors. In this review, we provide an overview of the fundamental properties of sophorolipids and analyze their applications in various fields including food, agriculture, pharmaceuticals, cosmetics, anticancer, and antimicrobial activities.
Review
Biotechnology & Applied Microbiology
Estefania Eras-Munoz et al.
Summary: Microbial biosurfactants are highly valuable and chemically stable compounds that have been widely used in the resolution of environmental problems, particularly in the bioremediation of recalcitrant pollutants. These biosurfactants function by reducing surface tension and facilitating emulsification and solubilization of pollutants. Recent research has focused on producing biosurfactants using alternative substrates in a circular economy context.
Article
Chemistry, Physical
Jochen Kleinen et al.
Summary: This study investigates the molecular aggregation structure and dynamics of commercially available Sophorolipid (SL) using DLS. The results demonstrate that the different degrees of protonation only impact the microscopic properties of SL.
COLLOIDS AND INTERFACES
(2022)
Article
Environmental Sciences
Alejandra Rodriguez et al.
Summary: This study investigated 9 different biomaterials and inert materials for the production of sophorolipids by Starmerella bombicola ATCC 22214. It was found that rice husk and wheat straw performed the best, with high yields. Additionally, a proportional correlation between sophorolipids yield and cumulative oxygen consumption was identified, suggesting that cumulative oxygen content can be used as an indirect measure to monitor the production process.
WASTE AND BIOMASS VALORIZATION
(2021)
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Biochemistry & Molecular Biology
Yue Li et al.
Summary: The study found that expressing cellulase genes in S. bombicola promoted the degradation of lignocellulosic cellulose, leading to the production of SLs. The titer of SLs significantly increased in the medium containing 2% glucose and 1% RAC.
APPLIED BIOCHEMISTRY AND BIOTECHNOLOGY
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Agricultural Engineering
Xiaomeng Hu et al.
Summary: The study explores the environmental-economic implications of producing SL crystals and syrup from food waste through a dynamic Life Cycle Assessment (dLCA) approach. The results showed the global warming potential (GWP) for 1 kg of SL crystals and syrup. The study also highlights the trade-offs between systemic environmental costs and economic benefits for design decisions based on the LCA and TEA results at the pilot plant.
BIORESOURCE TECHNOLOGY
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Summary: The optimization of pulsed electric field parameters for extracting natural saponins from Chubak root had significant effects on the properties of the samples. The Chubak root extract obtained under the optimal conditions showed good performance in ice cream formulation.
JOURNAL OF THE SCIENCE OF FOOD AND AGRICULTURE
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Green & Sustainable Science & Technology
Phavit Wongsirichot et al.
Summary: The replacement of traditional petroleum-based surfactants with renewable biosurfactants, such as sophorolipids, offers high productivity fermentation processes and excellent performance, but current large-scale production still relies on purified substrates, leading to significantly higher prices and limited commercial adoption. Therefore, it is crucial to produce sophorolipids from alternative biomass byproducts and wastes. The review highlights the potential of alternative feedstocks for sophorolipid production and identifies important knowledge gaps, with future improvements in productivity achievable through sophisticated fermentation schemes.
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Arnau Sala et al.
Summary: The study found that agro-industrial residues can be used as suitable substrates for fungal conidia production, achieving waste valorisation. The results demonstrate that a significant amount of fungal conidia can be produced using different waste substrates, with rice husk, potato peel, and whisky draff showing the best results.
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Jung-Hun Kim et al.
Summary: By optimizing the culture medium composition and utilizing fed-batch fermentation, production of Sophorolipids from C. batistae was significantly increased, with successful separation and purification of the SLs achieved.
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Summary: This review explores the biochemistry and biosynthesis of microbial surfactants, highlighting their potential applications in various sectors. Analysis reveals that all studied biosurfactants contain carbohydrates, aminoacids, lipids, and fattyacids, providing a foundation for the design and application of novel biosurfactants.
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Amanda Hipolito et al.
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Qin Shu et al.
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Yongkai Yuan et al.
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