Long noncoding RNA: An emerging diagnostic and therapeutic target in kidney diseases

Long noncoding RNAs (lncRNAs) have critical roles in the development of many diseases including kidney disease. An increasing number of studies have shown that lncRNAs are involved in kidney development and that their dysregulation can result in distinct disease processes, including acute kidney injury, chronic kidney disease, and renal cell carcinoma. Understanding the roles of lncRNAs in kidney disease may provide new diagnostic and therapeutic opportunities in the clinic. This review provides an overview of lncRNA characteristics, and biological function and discusses specific studies that provide insight into the function and potential application of lncRNAs in kidney disease treatment. Globally mortality rates from kidney diseases are sharply growing. The diagnosis and treatment of renal diseases are still delays, particularly in the early stages of the condition. It is necessary to develop more novel diagnostic and therapeutic procedures. Many studies conducted recently have connected long noncoding RNAs (lncRNAs) to the pathophysiology of different kidney diseases. In this review, we present an in-depth analysis of the present biogenesis, degradation, and functions of lncRNAs and highlight the current understanding of their roles in kidney diseases and their complications, such as acute kidney injury, diabetic nephropathy, membranous nephropathy, immunoglobulin A nephropathy, lupus nephritis, and chronic kidney disease.

Automated summary

Long noncoding RNAs (lncRNAs) play critical roles in kidney disease development and their dysregulation can lead to various disease processes. Understanding the function and potential application of lncRNAs in kidney disease may provide new diagnostic and therapeutic opportunities. This review provides an overview of lncRNA characteristics, function, and specific studies related to kidney disease treatment.