Organocatalytic enantioselective Mannich and retro-Mannich reactions and combinations of these reactions to afford tetrasubstituted α-amino acid derivatives

Organocatalytic asymmetric Mannich reactions and kinetic resolutions of the products via retro-Mannich reactions that afford enantiomerically enriched tetrasubstituted alpha-amino acid derivatives (alpha,alpha-disubstituted-alpha-amino acid derivatives) were developed. Furthermore, the combination of the Mannich reaction and the retro-Mannich reaction allowed access to products with almost perfect enantiopurities.

Automated summary

The study developed organocatalytic asymmetric Mannich reactions and kinetic resolutions of the products through retro-Mannich reactions, which resulted in enantiomerically enriched tetrasubstituted alpha-amino acid derivatives. Furthermore, the combination of Mannich reaction and retro-Mannich reaction allowed the access to products with almost perfect enantiopurities.