A single center experience of the first 100 next-generation sequencing renal gene panel testing during kidney transplant evaluation

Article Medicine, General & Internal

Trends in Cost Attributable to Kidney Transplantation Evaluation and Waiting List Management in the United States, 2012-2017

Xingxing S. Cheng et al.

Summary: This study aims to describe the temporal trends in Organ Acquisition Cost Center (OACC) costs per kidney transplantation and identify the factors associated with cost. The study found that OACC costs increased by 4% per year from 2012 to 2017 and were not solely attributable to the cost of organ procurement. Expanding the waiting list is likely to contribute to further increases in OACC costs and substantially increase Medicare liability.

JAMA NETWORK OPEN (2022)

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Article Urology & Nephrology

Genetic Etiologies for Chronic Kidney Disease Revealed through Next-Generation Renal Gene Panel

Anthony J. Bleyer et al.

Summary: The use of broad panel genetic testing by clinical nephrologists had a high success rate, similar to results obtained by academic centers specializing in genetics. Positive genetic findings were identified in 21.1% of cases, with the most common gene variants being PKD1, COL4A5, PKD2, COL4A4, COL4A3, and TTR.

AMERICAN JOURNAL OF NEPHROLOGY (2022)

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Article Medicine, Research & Experimental

Recipient APOL1 risk alleles associate with death-censored renal allograft survival and rejection episodes

Zhongyang Zhang et al.

Summary: The presence of recipient APOL1 risk alleles is independently associated with transplant outcomes, especially in African American and Hispanic recipients, potentially impacting immune response. This finding suggests broader implications for immune-mediated injury to native kidneys.

JOURNAL OF CLINICAL INVESTIGATION (2021)

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Article Urology & Nephrology