4.5 Article

Evaluation of an efficient data-driven ANN model to predict agglomerate collisions within Euler-Lagrange simulations

Related references

Note: Only part of the references are listed.
Article Computer Science, Interdisciplinary Applications

Heavy and light inertial particle aggregates in homogeneous isotropic turbulence: A study on breakup and stress statistics

Graziano Frungieri et al.

Summary: In this study, the breakup of inertial, solid aggregates in a three-dimensional turbulent flow was investigated using direct numerical simulation and Lagrangian tracking. The statistics of shear and drag stresses, which are responsible for aggregate breakup, were analyzed based on the point-particle approximation. The results showed that shear stresses, induced by turbulent velocity gradients, played a significant role in the breakup of both inertial and neutrally buoyant aggregates, while drag stresses dominated when the density ratio was different from unity. A transition from shear-dominated to drag-dominated breakup regime was observed, and a power-law relationship was found to describe the breakup rate of loose aggregates regardless of their inertia. This study provides insights into the mechanisms of aggregate breakup and offers breakup rates for population balance models.

COMPUTERS & FLUIDS (2023)

Article Engineering, Chemical

Data-driven ANN approach for binary agglomerate collisions including breakage and agglomeration

A. Khalifa et al.

CHEMICAL ENGINEERING RESEARCH & DESIGN (2023)

Article Thermodynamics

Neural-network based approach for modeling wall-impact breakage of agglomerates in particle-laden flows applied in Euler-Lagrange LES

A. Khalifa et al.

Summary: This study proposes a novel modeling approach based on artificial neural networks (ANN) for predicting the wall-impact breakage of agglomerates in wall-bounded particle-laden turbulent flows. The model uses two pre-trained artificial neural networks to predict the possibility of breakage and the resulting fragment size distribution, as well as the post-breakage velocities of the fragments. Extensive DEM simulations were used to train the networks, and the model was validated through Euler-Lagrange LES predictions. The results showed good agreement with a previous regression model.

INTERNATIONAL JOURNAL OF HEAT AND FLUID FLOW (2022)

Review Pharmacology & Pharmacy

Recent developments in the computational simulation of dry powder inhalers

Jesse Capecelatro et al.

Summary: This article reviews recent developments in computational modeling of dry powder inhalers (DPIs), focusing on the physical processes of aerosolization and deposition, performance evaluation using simulation techniques, and prospects for improvement.

ADVANCED DRUG DELIVERY REVIEWS (2022)

Article Mechanics

An efficient model for the breakage of agglomerates by wall impact applied to Euler-Lagrange LES predictions

A. Khalifa et al.

Summary: The study develops a model for predicting the impact of wall collisions on agglomerates in turbulent flows and describes the post-breakage kinetics of fragments based on extensive DEM simulations considering various impact conditions. The Weibull distribution functions are used to describe the parameters of the wall-impact model, with the shape and scale parameters mainly dependent on the impact angle of the agglomerate.

INTERNATIONAL JOURNAL OF MULTIPHASE FLOW (2021)

Review Pharmacology & Pharmacy

Flow and Particle Modelling of Dry Powder Inhalers: Methodologies, Recent Development and Emerging Applications

Zhanying Zheng et al.

Summary: This article focuses on the development of modelling methodologies for flow and particle behaviors in DPI devices and their applications to device design in several emerging fields. Various modelling methods, including the most recent multi-scale approaches, are covered and the latest simulation studies of different devices are summarised and critically assessed.

PHARMACEUTICS (2021)

Article Physics, Fluids & Plasmas

LES of Particle-Laden Flow in Sharp Pipe Bends with Data-Driven Predictions of Agglomerate Breakage by Wall Impacts

Ali Khalifa et al.

Summary: This study investigates the breakage of agglomerates in turbulent two-phase flow due to wall impact using a model based on two artificial neural networks. The simulation methodology is applied to flow through sharp pipe bends with different Reynolds numbers, revealing wall impact as the dominant mechanism for size distribution. The findings provide important insights for dry powder inhaler designs.

FLUIDS (2021)

Article Engineering, Chemical

Analysis, modelling and simulation of the fragmentation of agglomerates

Berend van Wachem et al.

CHEMICAL ENGINEERING SCIENCE (2020)

Article Computer Science, Interdisciplinary Applications

Refinement of breakup models for compact powder agglomerates exposed to turbulent flows considering relevant time scales

M. Breuer et al.

COMPUTERS & FLUIDS (2019)

Article Mechanics

Collision and breakup of fractal particle agglomerates in a shear flow

Farzad F. Dizaji et al.

JOURNAL OF FLUID MECHANICS (2019)

Article Pharmacology & Pharmacy

Towards quantitative prediction of the performance of dry powder inhalers by multi-scale simulations and experiments

Duy Nguyen et al.

INTERNATIONAL JOURNAL OF PHARMACEUTICS (2018)

Article Engineering, Chemical

Simulation of dry powder inhalers: Combining micro-scale, meso-scale and macro-scale modeling

Berend van Wachem et al.

AICHE JOURNAL (2017)

Article Chemistry, Medicinal

Optimization of a DPI Inhaler: A Computational Approach

Jovana Milenkovic et al.

JOURNAL OF PHARMACEUTICAL SCIENCES (2017)

Article Engineering, Mechanical

Numerical Analysis of Carrier Particle Motion in a Dry Powder Inhaler

Martin Sommerfeld et al.

JOURNAL OF FLUIDS ENGINEERING-TRANSACTIONS OF THE ASME (2016)

Review Thermodynamics

Point-Particle DNS and LES of Particle-Laden Turbulent flow - a state-of-the-art review

J. G. M. Kuerten

FLOW TURBULENCE AND COMBUSTION (2016)

Article Mechanics

Modeling and simulation of particle-wall adhesion of aerosol particles in particle-laden turbulent flows

N. Almohammed et al.

INTERNATIONAL JOURNAL OF MULTIPHASE FLOW (2016)

Article Engineering, Chemical

CFD-DEM investigation of the effect of agglomerate-agglomerate collision on dry powder aerosolisation

Zhenbo Tong et al.

JOURNAL OF AEROSOL SCIENCE (2016)

Article Pharmacology & Pharmacy

Numerical Modelling of Agglomeration and Deagglomeration in Dry Powder Inhalers: A Review

Jiecheng Yang et al.

CURRENT PHARMACEUTICAL DESIGN (2015)

Article Mechanics

Numerical simulations of aggregate breakup in bounded and unbounded turbulent flows

Matthaus U. Babler et al.

JOURNAL OF FLUID MECHANICS (2015)

Article Engineering, Chemical

Analysis of aerodynamic dispersion of cohesive clusters

G. Calvert et al.

CHEMICAL ENGINEERING SCIENCE (2013)

Article Mechanics

Prediction of turbulent particle-laden flow in horizontal smooth and rough pipes inducing secondary flow

M. Alletto et al.

INTERNATIONAL JOURNAL OF MULTIPHASE FLOW (2013)

Article Thermodynamics

Efficient simulation of particle-laden turbulent flows with high mass loadings using LES

Michael Breuer et al.

INTERNATIONAL JOURNAL OF HEAT AND FLUID FLOW (2012)

Review Respiratory System

Aerosol Deposition in Health and Disease

Chantal Darquenne

JOURNAL OF AEROSOL MEDICINE AND PULMONARY DRUG DELIVERY (2012)

Article Thermodynamics

Models, algorithms and validation for opensource DEM and CFD-DEM

Christoph Kloss et al.

PROGRESS IN COMPUTATIONAL FLUID DYNAMICS (2012)

Article Engineering, Chemical

Numerical investigation of the de-agglomeration mechanisms of fine powders on mechanical impaction

Z. B. Tong et al.

JOURNAL OF AEROSOL SCIENCE (2011)

Article Engineering, Environmental

Numerical study of the effects of particle size and polydispersity on the agglomerate dispersion in a cyclonic flow

Z. B. Tong et al.

CHEMICAL ENGINEERING JOURNAL (2010)

Article Engineering, Chemical

An extension of the hard-sphere particle-particle collision model to study agglomeration

Pawel Kosinski et al.

CHEMICAL ENGINEERING SCIENCE (2010)

Article Chemistry, Physical

Hydrodynamic properties of rigid fractal aggregates of arbitrary morphology

Yogesh M. Harshe et al.

JOURNAL OF COLLOID AND INTERFACE SCIENCE (2010)

Review Engineering, Chemical

Aerodynamic dispersion of cohesive powders: A review of understanding and technology

G. Calvert et al.

ADVANCED POWDER TECHNOLOGY (2009)

Article Physics, Fluids & Plasmas

Breakup of dense colloidal aggregates under hydrodynamic stresses

Alessio Zaccone et al.

PHYSICAL REVIEW E (2009)

Article Engineering, Chemical

Numerical modelling of the breakage of loose agglomerates of fine particles

Z. B. Tong et al.

POWDER TECHNOLOGY (2009)

Article Engineering, Chemical

Agglomeration of fine particles subjected to centripetal compaction

R. Y. Yang et al.

POWDER TECHNOLOGY (2008)

Article Chemistry, Multidisciplinary

Influence of mouthpiece geometry on the aerosol delivery performance of a dry powder inhaler

Matthew S. Coates et al.

PHARMACEUTICAL RESEARCH (2007)

Article Engineering, Chemical

Prediction of aerosol deposition in 90° bends using LES and an efficient Lagrangian tracking method

M. Breuer et al.

JOURNAL OF AEROSOL SCIENCE (2006)

Article Thermodynamics

A challenging test case for large eddy simulation: high Reynolds number circular cylinder flow

M Breuer

INTERNATIONAL JOURNAL OF HEAT AND FLUID FLOW (2000)