4.7 Article

Zishen Tongyang Huoxue decoction (TYHX) alleviates sinoatrial node cell ischemia/reperfusion injury by directing mitochondrial quality control via the VDAC1-β-tubulin signaling axis

Related references

Note: Only part of the references are listed.
Review Cell Biology

Autophagy in age-related macular degeneration

Kai Kaarniranta et al.

Summary: Age-related macular degeneration (AMD) is a leading cause of visual impairment in the aging population. The progression of AMD is characterized by atrophic alterations in the retinal pigment epithelium and the formation of lipofuscin and deposits. Chronic oxidative stress, protein aggregation, and inflammation may contribute to the development of AMD.

AUTOPHAGY (2023)

Article Biochemistry & Molecular Biology

Molecular Mechanisms of Mitochondrial Quality Control in Ischemic Cardiomyopathy

Xing Chang et al.

Summary: Ischemic cardiomyopathy (ICM) is a type of coronary heart disease that is related to the pathological mechanism of primary dilated cardiomyopathy. ICM is mainly caused by long-term myocardial ischemia and results in diffuse myocardial fibrosis, affecting the cardiac ejection function. The pathogenesis of ICM involves inflammation, myocardial hypertrophy, fibrosis, and vascular remodeling, with mitochondrial quality control (MQC) playing an important role.

INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES (2023)

Article Plant Sciences

β-tubulin contributes to Tongyang Huoxue decoction-induced protection against hypoxia/reoxygenation-induced injury of sinoatrial node cells through SIRT1-mediated regulation of mitochondrial quality surveillance

Xing Chang et al.

Summary: TYHX exerts protective effects against sinus node cell injury under hypoxic stress by maintaining beta-tubulin and activating SIRT1, thereby alleviating hypoxic stress injury and protecting mitochondrial function in SNCs.

PHYTOMEDICINE (2023)

Review Biochemistry & Molecular Biology

Molecular Mechanisms of Mitochondrial Quality Control in Ischemic Cardiomyopathy

Xing Chang et al.

Summary: Ischemic cardiomyopathy (ICM) is a type of coronary heart disease that occurs in the long-term myocardial ischemia, leading to diffuse myocardial fibrosis. The pathogenesis of ICM is closely related to coronary heart disease, mainly caused by coronary stenosis or vascular occlusion. Mitochondrial Quality Control (MQC) plays an important role in regulating mitochondrial function in cardiomyocytes and affects the morphological structure/function and lifespan of mitochondria. This review discusses the role of MQC in the pathogenesis of ICM and provides important evidence for targeting MQC for ICM.

INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES (2023)

Article Biochemistry & Molecular Biology

MCU (mitochondrial Ca2+ uniporter) makes the calcium go round

Grant C. Walters et al.

Summary: Store-operated Ca2+ entry (SOCE) is a major mechanism controlling Ca2+ signaling and Ca2+-dependent functions. The mitochondrial Ca2+ uniporter plays multiple roles in regulating SOCE, Ca2+ dynamics, transcription, and lymphocyte activation.

JOURNAL OF BIOLOGICAL CHEMISTRY (2022)

Review Cardiac & Cardiovascular Systems

The role of mitochondrial fission in cardiovascular health and disease

Justin M. Quiles et al.

Summary: In this Review, the authors compare the roles of mitochondrial fission in physiological and pathological contexts, and discuss the therapeutic potential of preventing excessive mitochondrial fission in the heart and vasculature.

NATURE REVIEWS CARDIOLOGY (2022)

Article Environmental Sciences

Perfluorooctane sulfonate induces mitochondrial calcium overload and early hepatic insulin resistance via autophagy/detyrosinated alpha-tubulin-regulated IP3R2-VDAC1-MICU1 interaction

Zhanchen Dong et al.

Summary: This study found that PFOS causes insulin resistance by promoting autophagy and mitochondrial calcium accumulation. The study also identified detyrosinated alpha-tubulin as a key component connecting autophagy and mitochondrial calcium response.

SCIENCE OF THE TOTAL ENVIRONMENT (2022)

Article Biochemistry & Molecular Biology

DNA-PKcs interacts with and phosphorylates Fis1 to induce mitochondrial fragmentation in tubular cells during acute kidney injury

Shiyuan Wang et al.

Summary: The catalytic subunit of DNA-dependent protein kinase (DNA-PKcs) plays a crucial role in acute kidney injury (AKI) development, through its interaction with Fis1 and phosphorylation of Fis1 at Thr(34), resulting in mitochondrial fragmentation, tubular cell death, and renal dysfunction.

SCIENCE SIGNALING (2022)

Article Cell Biology

VDAC1 regulates neuronal cell loss after retinal trauma injury by a mitochondria-independent pathway

Erica de Sousa et al.

Summary: The regulation of VDAC1 plays a crucial role in neuronal survival and the activation of microglial cells. Inhibition of VDAC1 oligomerization has neuroprotective effects and prevents microglial polarization. These findings suggest that VDAC1 could be a potential therapeutic target in neuronal disorders.

CELL DEATH & DISEASE (2022)

Article Endocrinology & Metabolism

Mitochondrial quality control mechanisms as molecular targets in diabetic heart

Xing Chang et al.

METABOLISM-CLINICAL AND EXPERIMENTAL (2022)

Article Cell Biology

A partial reduction of VDAC1 enhances mitophagy, autophagy, synaptic activities in a transgenic Tau mouse model

Murali Vijayan et al.

Summary: This study reveals the age-dependent increase of VDAC1 in Alzheimer's disease and its abnormal interaction with P-Tau, which results in mitochondrial defects. Partial reduction of VDAC1 in transgenic TAU mice reduces mitochondrial and synaptic toxicities and improves behavioral impairments.

AGING CELL (2022)

Review Medicine, General & Internal

Therapeutic strategies in ischemic cardiomyopathy: Focus on mitochondria! quality surveillance

Xing Chang et al.

Summary: Despite the complexity of the molecular mechanisms, effective therapies for ischemic cardiomyopathy (ICM) are still lacking. Dysregulation of the mitochondrial quality surveillance (MQS) system plays a key role in mitochondrial dysfunction and cardiomyocyte injury during myocardial ischemia. A better understanding of the pathogenesis of ICM may lead to the development of novel preventive and therapeutic strategies.

EBIOMEDICINE (2022)

Review Cell Biology

Mitochondrial VDAC1: A Potential Therapeutic Target of Inflammation-Related Diseases and Clinical Opportunities

Hang Hu et al.

Summary: The multifunctional protein VDAC1 plays a crucial role in maintaining mitochondrial function and regulating inflammation-related diseases. Targeting VDAC1 could be a novel therapeutic strategy for treating inflammation-related disorders.

CELLS (2022)

Article Biology

Mitochondrial Ca2+ uptake by the MCU facilitates pyramidal neuron excitability and metabolism during action potential firing

Christopher J. Groten et al.

Summary: This study demonstrated the importance of MCU-mediated mitochondrial Ca2+ uptake in regulating neuronal bioenergetics and excitability in the brain. The researchers used single-cell patch-clamp recording and two-photon imaging to show that MCU activation promotes energy metabolism and controls excitability in neurons. The study also found that the relationship between MCU activation and firing rate varied between different brain regions.

COMMUNICATIONS BIOLOGY (2022)

Article Cardiac & Cardiovascular Systems

The Effect of the Tongyang Huoxue Recipe (TYHX) on the Ito/IKur in Ischemia/Reperfusion Sinoatrial Node Cells

Yanli Wang et al.

Summary: TYHX has a significant effect on the I-to and I-Kur currents in SNCs, increasing peak current density, accelerating activation, and reducing inactivation. This may be the mechanism behind TYHX shortening the duration of the repolarization action potential and accelerating spontaneous pulsation.

CARDIOVASCULAR THERAPEUTICS (2022)

Article Biochemistry & Molecular Biology

Structural visualization of the tubulin folding pathway directed by human chaperonin TRiC/CCT

Daniel Gestaut et al.

Summary: The ATP-dependent ring-shaped chaperonin TRiC/CCT plays a crucial role in cellular proteostasis. It has been found that TRiC guides the folding pathway of its substrates through site-specific interactions with conserved regions in its chamber. The chamber of TRiC provides chemical and topological directives that shape the folding landscape of its obligate substrates.
Review Biochemistry & Molecular Biology

Mitochondria as Therapeutic Targets in Transplantation

Kourosh Saeb-Parsy et al.

Summary: Advancements in surgical techniques, technology, and immune suppression have revolutionized organ transplantation, however, the metabolic changes during transplantation have been overlooked. Understanding the metabolic changes, especially those associated with mitochondria, could lead to improvements in transplanted grafts' function and longevity, ultimately increasing the pool of available organs for transplantation.

TRENDS IN MOLECULAR MEDICINE (2021)

Article Biochemistry & Molecular Biology

Phosphoglycerate mutase 5 exacerbates cardiac ischemia-reperfusion injury through disrupting mitochondrial quality control

Hang Zhu et al.

Summary: In the context of cardiac ischemia-reperfusion injury, PGAM5 plays a role in driving cardiomyocyte necroptosis by regulating mitochondrial quality control, while also suppressing necroptosis without preventing apoptosis, leading to improved heart function and reduced inflammation response.

REDOX BIOLOGY (2021)

Article Cell Biology

SIRT5-Related Desuccinylation Modification Contributes to Quercetin-Induced Protection against Heart Failure and High-Glucose-Prompted Cardiomyocytes Injured through Regulation of Mitochondrial Quality Surveillance

Xing Chang et al.

Summary: The study found that quercetin can inhibit myocardial fibrosis and improve cardiac function by regulating mitochondrial quality surveillance, inhibiting inflammatory response, and oxidative stress injury. Additionally, quercetin promotes IDH2 desuccinylation mediated by SIRT5, maintaining mitochondrial homeostasis and reducing the risk of heart failure.

OXIDATIVE MEDICINE AND CELLULAR LONGEVITY (2021)

Article Cell Biology

Quercetin Improves Cardiomyocyte Vulnerability to Hypoxia by Regulating SIRT1/TMBIM6-Related Mitophagy and Endoplasmic Reticulum Stress

Xing Chang et al.

Summary: The study aimed to investigate the protective effect of quercetin on human cardiomyocytes subjected to hypoxia-induced oxidative stress damage and its underlying mechanism. Results showed that quercetin can inhibit hypoxia-induced oxidative stress damage by regulating mitophagy and endoplasmic reticulum stress pathways, enhancing the resistance of cardiomyocytes.

OXIDATIVE MEDICINE AND CELLULAR LONGEVITY (2021)

Article Ophthalmology

VDAC1 regulates mitophagy in NLRP3 inflammasome activation in retinal capillary endothelial cells under high-glucose conditions

Jie Xie et al.

Summary: The study revealed that VDAC1-mediated mitophagy plays a crucial role in regulating NLRP3 inflammasome activation in retinal capillary endothelial cells under high-glucose conditions. VDAC1 overexpression promoted PINK1 expression, inhibited NLRP3 activation, and altered cell biological behaviors under high-glucose conditions.

EXPERIMENTAL EYE RESEARCH (2021)

Article Cell Biology

Tongyang Huoxue Decoction (TYHX) Ameliorating Hypoxia/Reoxygenation-Induced Disequilibrium of Calcium Homeostasis and Redox Imbalance via Regulating Mitochondrial Quality Control in Sinoatrial Node Cells

Xing Chang et al.

Summary: TYHX is commonly used in treating SSS and improving SAN fibrosis. It regulates redox balance and mitochondrial quality control to protect SANCs, playing a role in ameliorating calcium homeostasis disorder and redox imbalance.

OXIDATIVE MEDICINE AND CELLULAR LONGEVITY (2021)

Article Biochemistry & Molecular Biology

Mitophagy coordinates the mitochondrial unfolded protein response to attenuate inflammation-mediated myocardial injury

Yue Wang et al.

Summary: Mitophagy and UPRmt, although slightly activated by myocardial stress, work together to maintain mitochondrial performance and protect against inflammation-related myocardial injury. Mitophagy modulation of UPRmt could be a potential therapeutic strategy for myocardial stress.

REDOX BIOLOGY (2021)

Article Cell Biology

Antidepressant drug sertraline modulates AMPK-MTOR signaling-mediated autophagy via targeting mitochondrial VDAC1 protein

Hui-Yun Hwang et al.

Summary: This study demonstrates that the antidepressant drug sertraline can induce cellular autophagy by targeting mitochondrial VDAC1, providing a potential new drug candidate for autophagy-related diseases. Additionally, sertraline also suppresses tauopathy by promoting the autophagic degradation of MAPT protein.

AUTOPHAGY (2021)

Review Multidisciplinary Sciences

Mitochondrial TCA cycle metabolites control physiology and disease

Inmaculada Martinez-Reyes et al.

NATURE COMMUNICATIONS (2020)

Review Biochemistry & Molecular Biology

Complex interplay between autophagy and oxidative stress in the development of pulmonary disease

Wojciech Ornatowski et al.

REDOX BIOLOGY (2020)

Review Biochemistry & Molecular Biology

VDAC1 at the Intersection of Cell Metabolism, Apoptosis, and Diseases

Varda Shoshan-Barmatz et al.

BIOMOLECULES (2020)

Review Cell Biology

The Tubulin Detyrosination Cycle: Function and Enzymes

Joppe Nieuwenhuis et al.

TRENDS IN CELL BIOLOGY (2019)

Review Cell Biology

Mitochondria in the signaling pathways that control longevity and health span

Mansour Akbari et al.

AGEING RESEARCH REVIEWS (2019)

Review Cardiac & Cardiovascular Systems

Mitochondrial quality control mechanisms as molecular targets in cardiac ageing

Anna Picca et al.

NATURE REVIEWS CARDIOLOGY (2018)

Editorial Material Cardiac & Cardiovascular Systems

Sick Sinus Syndrome Synopsis

Gordon A. Ewy

JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY (2014)

Article Cell Biology

PINK1/Parkin-mediated mitophagy is dependent on VDAC1 and p62/SQSTM1

Sven Geisler et al.

NATURE CELL BIOLOGY (2010)

Review Oncology

Microtubules and resistance to tubulin-binding agents

Maria Kavallaris

NATURE REVIEWS CANCER (2010)

Article Multidisciplinary Sciences

An ATP gate controls tubulin binding by the tethered head of kinesin-1

Maria C. Alonso et al.

SCIENCE (2007)