Related references
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Article
Oncology
Ran Hao et al.
Summary: This study identified aberrant circRNAs in breast cancer tissues, and found that circRRM2 was upregulated in tumor tissues of breast cancer patients. Functional experiments showed that circRRM2 promoted cell migration and invasion, and acted as an oncogene in breast cancer. Mechanistic studies revealed a positive feedback loop involving circRRM2/IGF2BP1/MYC in breast cancer.
CANCER CELL INTERNATIONAL
(2023)
Review
Biochemistry & Molecular Biology
Emma Nolan et al.
Summary: Breast cancer is a major cause of cancer-related death in women due to its heterogeneity, metastasis, and resistance to treatment. Recent advances in genomics and transcriptomics have revealed distinct subtypes, molecular drivers, evolutionary patterns, and prognostic markers. Moreover, the integration of high-resolution single-cell and spatial technologies has revealed the significance of the breast cancer ecosystem and different cellular neighborhoods.
Article
Biochemistry & Molecular Biology
Jia Yi et al.
Summary: This study found that circPVT1, a circular RNA derived from the lncRNA PVT1, is highly expressed in ERa-positive breast cancer cell lines and tumors and plays an important role in breast tumorigenesis and endocrine therapy resistance. CircPVT1 acts as a ceRNA to sequester miR-181a-2-3p, promoting the expression of ESR1 and downstream ERa-target genes, and facilitates breast cancer cell growth. Additionally, circPVT1 interacts with MAVS protein, disrupting the RIGI-MAVS complex formation, inhibiting type I interferon signaling pathway and anti-tumor immunity. ASO targeting circPVT1 inhibits ERa-positive breast cancer cell and tumor growth, sensitizing tamoxifen-resistant ERa-positive breast cancer cells to tamoxifen treatment. Therefore, circPVT1 may serve as a diagnostic biomarker and therapeutic target for ERa-positive breast cancer in the clinic.
Article
Oncology
Boxuan Zhou et al.
JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH
(2023)
Article
Medicine, Research & Experimental
Bin Wang et al.
Summary: By screening circRNA microarray, it was found that circDNAJC11 was significantly upregulated in triple-negative breast cancer tissues and cells. High expression of circDNAJC11 was closely correlated with a poor prognosis of breast cancer patients and acted as an independent risk factor. Functionally, circDNAJC11 promoted breast cancer cell proliferation, migration, invasion, and tumor growth. Mechanistically, circDNAJC11 combined with TAF15 to stabilize MAPK6 mRNA and activate the MAPK signaling pathway for breast cancer progression.
JOURNAL OF TRANSLATIONAL MEDICINE
(2023)
Article
Chemistry, Multidisciplinary
Ying Liu et al.
Summary: This study identifies a novel circRNA, circTBC1D14, that is upregulated in TNBC and associated with poor prognosis in breast cancer patients. The authors show that FUS interacts with circTBC1D14 and induces cyclization. Hypoxic conditions induce the formation of FUS-circTBC1D14-associated SGs in the cytoplasm, which enhance lysosome-associated autophagy flux and promote tumor progression in TNBC.
Review
Genetics & Heredity
Bashdar Mahmud Hussen et al.
Summary: Breast cancer is the most common malignant tumor in women. Exosomes are extracellular vesicles released via exocytosis and contain various molecules, including circular RNAs. Exosomal circRNAs can either promote or suppress cancer by interfering with biological pathways. The role of exosomal circRNAs in breast cancer progression and their potential as therapeutic targets and diagnostics is still unclear and requires further study.
FRONTIERS IN GENETICS
(2023)
Article
Biochemical Research Methods
Lishen Zhang et al.
Summary: In this study, we propose a method called CRMSS for discriminating circRNA-RBP binding sites based on multi-scale characterizing sequence and structure features. The CRMSS achieves superior performance over state-of-the-art methods in predicting circRNA-RBP binding.
BRIEFINGS IN BIOINFORMATICS
(2023)
Article
Oncology
Bin Yang et al.
Summary: The study investigates the potential of miRNAs in whole blood as biomarkers for breast cancer axillary lymph node metastasis (ALNM). It identifies downregulated expression of miR-367-3p, miR-548aq-5p, and miR-4710 in breast cancer with ALNM. The three-miRNA signature shows better predictive value and may serve as biomarkers for breast cancer with ALNM.
CLINICAL BREAST CANCER
(2023)
Review
Oncology
Rina Guo et al.
Summary: CircRNA, a special non-coding RNA molecule, participates in the generation and progression of thyroid and breast cancer. Both cancers are hormonally influenced and share similar characteristics. However, there is a lack of clinical studies on the potential molecular mechanisms affecting prognosis, despite the use of targeted anti-tumor drugs with tumor markers in clinical settings.
CLINICAL & TRANSLATIONAL ONCOLOGY
(2023)
Article
Biochemical Research Methods
Yawei Wang et al.
Summary: In this study, a new algorithm, Evolutionary Deep Convolutional Neural Network (EDCNN), was proposed for identifying protein-RNA interactions. Experimental results demonstrated the superior performance of EDCNN on large-scale CLIP-seq datasets. Furthermore, analyses of time complexity, parameters, and motifs confirmed the effectiveness of the proposed algorithm.
Article
Cell Biology
Di Chen et al.
Summary: This study reveals that ER beta 2 is upregulated in some TNBC cells and promotes TNBC cell growth, migration, and invasion by regulating the hsa_circ_0000732/miR-1184 axis.
INFLAMMATION RESEARCH
(2022)
Review
Cell Biology
Junhong Chen et al.
Summary: circRNAs are closed back-splicing products of precursor mRNA with stable expression and unique structure in eukaryotes. They play essential biological roles in tumors through various regulatory mechanisms, such as biogenesis regulation by RNA-binding proteins. Furthermore, circRNAs can act as protein sponges, be translated themselves, or regulate posttranslational modifications of proteins, revealing potential interactions with functional proteins in cancer and uncovering unknown regulatory mechanisms.
JOURNAL OF CELLULAR PHYSIOLOGY
(2022)
Article
Medicine, Research & Experimental
Wen-Hui Huang et al.
Summary: This study found that circRNA WW domain containing adaptor with coiled-coil (circWAC) promotes the growth, migration, and invasion, and inhibits apoptosis of breast cancer cells through regulating the miR-599/E2F3 pathway. This finding provides a novel potential target for breast cancer therapy.
KAOHSIUNG JOURNAL OF MEDICAL SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Yun Ling et al.
Summary: The study identified a circRNA circCDYL2 that is overexpressed in HER2(+) breast cancer patients resistant to trastuzumab, playing a critical role in maintaining HER2 signaling and contributing to trastuzumab resistance. High levels of circCDYL2 were associated with rapid recurrence and shorter survival in HER2(+) breast cancer patients, suggesting circCDYL2 as a potential biomarker for trastuzumab resistance.
Review
Oncology
Lasse S. Kristensen et al.
Summary: Circular RNAs (circRNAs) are a novel class of primarily non-coding RNAs with increasingly recognized roles in cancer development and progression through diverse mechanisms of action. In this review, the authors summarize the current understanding of circRNA biogenesis, regulation, physiological functions and pathophysiological roles in cancer. They also discuss the clinical potential of circRNAs as biomarkers, therapeutic agents and drug targets in oncology, as well as the research controversies, technical issues, and biological knowledge gaps that need to be addressed.
NATURE REVIEWS CLINICAL ONCOLOGY
(2022)
Article
Biochemical Research Methods
Xin Dong et al.
Summary: This article introduces a novel algorithm, circRIP, for identifying circRNA-RBP interactions from RIP-Seq and eCLIP data. The algorithm successfully identified multiple circRNAs binding to different RBPs, which is of great significance for further exploring the functions of circRNAs.
BRIEFINGS IN BIOINFORMATICS
(2022)
Article
Biotechnology & Applied Microbiology
Yaming Li et al.
Summary: The protein-coding ability of circRNAs in TNBC has not been well understood. This study identified a circRNA called circ-EIF6, which was associated with poorer prognosis and clinicopathological characteristics in TNBC patients. Functional experiments showed that circ-EIF6 promoted proliferation and metastasis of TNBC cells, mediated by encoding a novel peptide called EIF6-224aa that interacted with MYH9, leading to activation of the Wnt/β-catenin pathway.
Article
Biochemistry & Molecular Biology
Rui Yang et al.
Summary: This study identified a novel hypoxia-responsive circRNA named circWSB1, which could interact with USP10 and promote the progression of BC. It may serve as a prognostic biomarker and therapeutic target for BC patients.
Article
Cell Biology
Yunhe Yu et al.
Summary: This study identified circRPAP2 as a downregulated circular RNA in breast cancer, which is correlated with axillary lymph node metastasis and TNM stage, and can inhibit the proliferation and migration of breast cancer. CircRPAP2 exerts its function by affecting the binding of SRSF1 and PTK2, providing new insights into the pathogenesis of breast cancer.
CELL DEATH DISCOVERY
(2022)
Article
Cell Biology
Xiaojin Song et al.
Summary: This study identified a novel circRNA, circEIF3H, with significant cancer-promoting function in the progression of TNBC. It acts as a scaffold for IGF2BP2/HuR to regulate mRNA stability. This finding provides a potential target for developing individualized therapy for TNBC.
CELL DEATH DISCOVERY
(2022)
Article
Cell Biology
Xuehui Wang et al.
Summary: In this study, it was found that circPRKCI, derived from the PRKCI gene, was highly expressed in TNBC and could promote the proliferation and migration of TNBC by regulating the WBP2 and PI3K/AKT signaling pathway, providing a new avenue for TNBC therapy.
CELL DEATH DISCOVERY
(2022)
Article
Oncology
Xiaolong Wang et al.
Summary: Our study revealed the downregulation of circRNA-CREIT in doxorubicin resistant TNBC cells and its association with poor prognosis. We identified the RNA binding protein DHX9 as responsible for the reduction in circRNA-CREIT by interacting with the flanking inverted repeat Alu (IRAlu) sequences and inhibiting back-splicing. Mechanistically, circRNA-CREIT acted as a scaffold to facilitate the interaction between PKR and the E3 ligase HACE1, leading to proteasomal degradation of PKR protein via K48-linked polyubiquitylation and attenuation of the assembly of stress granules (SGs) to activate the RACK1/MTK1 apoptosis signaling pathway. Moreover, circRNA-CREIT could be packaged into exosomes and disseminate doxorubicin sensitivity among TNBC cells.
JOURNAL OF HEMATOLOGY & ONCOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Peng Liu et al.
Summary: Metastasis of breast cancer remains a major cause of cancer-related death globally. Recent research indicates that circRNAs are associated with tumorigenesis and metastasis in breast cancer. However, the biological mechanism of circRNAs in liver metastatic breast cancer is still unclear. In this study, we identified circEZH2 through microarray analysis and confirmed its existence and expression in liver metastases of breast cancer. We demonstrated that circEZH2 is upregulated in liver metastases and predicts poor prognosis in breast cancer patients. Functionally, circEZH2 promotes the vitality and invasion of breast cancer cells, and its knockdown has the opposite effects. Furthermore, circEZH2 overexpression promotes tumorigenesis and liver metastasis in vivo. Mechanistically, circEZH2 acts as a sponge for miR-217-5p, leading to upregulation of KLF5, which activates FUS transcription and facilitates the back-splicing program of circEZH2. Additionally, KLF5 transcriptionally upregulates CXCR4, thereby accelerating epithelial-mesenchymal transition in breast cancer. In conclusion, we have identified a novel feedback loop involving FUS/circEZH2/KLF5/CXCR4, and circEZH2 may serve as a potential biomarker and therapeutic target for breast cancer patients.
Article
Cell Biology
Xuehui Wang et al.
Summary: In this study, a novel circRNA called circSEMA4B was identified, which could encode a protein called SEMA4B-211aa. Both circSEMA4B and SEMA4B-211aa were downregulated in breast cancer tissues and cell lines. Functional investigation revealed that circSEMA4B and SEMA4B-211aa could inhibit the proliferation and migration of breast cancer cells. CircSEMA4B inhibited AKT phosphorylation through the miR-330-3p/PDCD4 axis, while SEMA4B-211aa inhibited AKT phosphorylation by binding to p85.
CELL DEATH & DISEASE
(2022)
Article
Oncology
Xianguo Meng et al.
Summary: This study reveals the important role of a newly discovered circRNA, circBRWD3, in the tumorigenesis and progression of breast cancer. CircBRWD3 expression is upregulated in breast cancer tissues and is associated with poor prognosis. Mechanistically, circBRWD3 regulates the miR-142-3p, miR-142-5p, and RAC1/PAK1 signaling pathway to promote tumor formation and progression. Additionally, circBRWD3 expression is positively regulated by EIF4A3. These findings provide valuable scientific data for the early diagnosis and therapy of breast cancer patients.
Article
Medicine, Research & Experimental
Fengzhi Ding et al.
Summary: This study successfully generated a CM-specific CKO mouse model and found that deletion of circHIPK3 leads to decreased cardiac function and cellular senescence. Additionally, UMSC-Exos exert anti-senescence and cardio-protective effects by delivering circHIPK3.
Article
Biochemistry & Molecular Biology
Hang Chen et al.
Summary: This study identified a novel hypoxia-induced circRNA, circPFKFB4, and demonstrated its role in promoting breast cancer progression. The study revealed an interaction between circPFKFB4 and the CRL4DDB2 E3 ubiquitin ligase and suggested circPFKFB4 as a potential biomarker and therapeutic target for breast cancer.
INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES
(2022)
Article
Genetics & Heredity
Xiao-Yu Zhang et al.
Summary: This study identified the tumor-suppressive role of circ_0000442 in breast cancer for the first time and found PTEN as a novel direct target of miR-148b-3p. The regulatory role of circ_0000442/miR-148b-3p/PTEN/PI3K/Akt axis was preliminarily confirmed in breast cancer cells and mouse models. These findings provide important progress in understanding breast cancer and lay the foundation for further research on the function, diagnosis, therapy, and prognosis of circular RNAs in breast cancer.
Article
Cardiac & Cardiovascular Systems
Juan Chen et al.
Summary: The study found that circMMP11 is overexpressed in NSCLC and predicts poor survival, showing a close correlation with miR-143. In NSCLC cells, overexpression of circMMP11 reduced miR-143 expression and increased miR-143 methylation. MiR-143 reversed the enhancing effects of circMMP11 overexpression on cell proliferation.
JOURNAL OF CARDIOTHORACIC SURGERY
(2021)
Article
Cell Biology
Meiheban Bazhabayi et al.
Summary: CircRNAs play an important role in regulating HER-2-positive breast cancer, with circGFRA1 identified as a key player. CircGFRA1 binds to miR-1228 through the ceRNA mechanism, thereby modulating the expression of AIFM2 and impacting the progression of HER-2-positive breast cancer. This study suggests that circGFRA1 could be a novel and promising treatment option for HER-2-positive breast cancer.
JOURNAL OF CELLULAR AND MOLECULAR MEDICINE
(2021)
Article
Medicine, Research & Experimental
Jin-xiu Zhong et al.
Summary: Circ-ERBB2 is abnormally expressed in tumor tissues of HER2-positive breast cancer patients and accelerates cancer progression through the circ-ERBB2/miR-136-5p/TFAP2C or circ-ERBB2/miR-198/TFAP2C axis.
JOURNAL OF TRANSLATIONAL MEDICINE
(2021)
Article
Biochemistry & Molecular Biology
Jie Li et al.
Summary: A novel circRNA circCD44 is highly expressed in triple-negative breast cancer (TNBC) and promotes TNBC progression by sponging miR-502-5p and interacting with IGF2BP2, leading to enhanced cell proliferation, migration, invasion, and tumorigenesis. CircCD44 may serve as a potential diagnostic and therapeutic marker for TNBC patients.
Article
Biochemistry & Molecular Biology
Lei Wang et al.
Summary: CircWAC/miR-142/WWP1 form a competing endogenous RNA (ceRNA) network to regulate PI3K/AKT signaling activity in TNBC cells and affect the chemosensitivity of cells.
Article
Biochemistry & Molecular Biology
Tong Chen et al.
Summary: The study found that the novel circRNA circHIF1A was significantly overexpressed in TNBC, associated with metastasis, poor prognosis, and the TNBC subtype. CircHIF1A modulated the expression of NFIB and FUS via a positive feedback loop, leading to activation of the AKT/STAT3 signaling pathway. CircHIF1A may serve as a potential biomarker for breast cancer diagnosis and a therapeutic target for TNBC treatment.
Article
Medicine, Research & Experimental
Yujie Cai et al.
Summary: Circ-NOL10 is downregulated in breast cancer and associated with aggressive characteristics and shorter survival time. Upregulation of Circ-NOL10 promotes apoptosis, decreases proliferation, and inhibits invasion and migration.
MOLECULAR THERAPY-NUCLEIC ACIDS
(2021)
Article
Medicine, Research & Experimental
Xuehui Wang et al.
Summary: This study reveals the crucial role of hsa_circ_0068631 in breast cancer, showing that it regulates tumor biological activities by influencing the expression and stability of c-Myc. The findings provide a new target for breast cancer treatment.
MOLECULAR THERAPY-NUCLEIC ACIDS
(2021)
Review
Biochemistry & Molecular Biology
Shuailong Zheng et al.
Summary: circRNA and their chaperoned RBPs play critical roles in biological functions, significantly contributing to normal animal development and disease. This review systematically characterizes the possible molecular mechanisms of circRNA-protein interactions, summarizes the latest research on circRNA-protein interactions in muscle development and myocardial disease, and discusses the future application of circRNA in treating muscle diseases.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Cell Biology
Da-Hong Chen et al.
Summary: This review discusses the relationship between non-coding RNA m6A modification and cancer progression from the perspective of various cancers, focusing on important mechanisms such as proliferation, apoptosis, invasion and metastasis, tumor angiogenesis. Clinical applications are introduced to illustrate the broad research prospects of non-coding RNA m6A modification in cancer research.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Biochemical Research Methods
Jyun-Yu Jiang et al.
Summary: circRNA is a novel class of long non-coding RNAs that play important roles in gene regulation and disease association. The JEDI framework, utilizing deep learning and a cross-attention layer, effectively predicts circRNAs, outperforming existing methods significantly.
Article
Biochemistry & Molecular Biology
Qun Liu et al.
Summary: This study demonstrated that hsa_circ_0088088 is upregulated in breast malignancy, with higher expression associated with unfavorable prognosis. hsa_circ_0088088 promotes cell growth and metastasis in MDA-MB-231 cells by regulating miR-135-5p and EIF4A3. This suggests that EIF4A3-induced hsa_circ_0088088 stimulates the carcinogenic effects of breast tumors by sponging miR-135-5p.
JOURNAL OF BIOCHEMICAL AND MOLECULAR TOXICOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Xiaosong Wang et al.
Summary: The study revealed that circACTN4 is upregulated in breast cancer tissues and cells, promoting tumor growth, invasion, and metastasis, and correlating with clinical stage and prognosis. circACTN4 interacts with FUBP1 to activate MYC transcription, facilitating breast cancer progression.
Article
Medicine, General & Internal
Qi Huang et al.
Summary: The study demonstrates that circ_0103552 up-modulates CYR61 expression by targeting miR-515-5p in breast cancer cells, thereby facilitating the proliferation, migration, and invasion of breast cancer cells.
TOHOKU JOURNAL OF EXPERIMENTAL MEDICINE
(2021)
Article
Biochemical Research Methods
Yuning Yang et al.
Summary: The study introduces a new computational method iCircRBP-DHN for discriminating circRNA-RBP binding sites using deep hierarchical networks. Experimental results demonstrate that the proposed method outperforms other algorithms on 37 circRNAs datasets and 31 linear RNAs datasets. The novel encoding schemes provide improved performance.
BRIEFINGS IN BIOINFORMATICS
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Article
Biochemistry & Molecular Biology
Zhi Li et al.
Summary: The newly discovered circMETTL3 in breast cancer is significantly upregulated and may play a crucial role in promoting cell proliferation, migration, and invasion. It functions as a ceRNA of miR-31-5p, potentially upregulating CDK1, and its m6A modification could influence its expression, suggesting a new therapeutic target for breast cancer.
INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES
(2021)
Review
Biochemical Research Methods
Liang Chen et al.
Summary: Circular RNAs (circRNAs) are a unique class of RNA molecules produced by back-splicing of linear RNA, and recent advances in sequencing technologies and bioinformatics tools have greatly expanded our understanding of their biological functions and practical applications. There are now numerous bioinformatics tools available for circRNA annotation, identification, and network analysis, which continue to evolve to support various research projects in this field.
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