Journal
TETRAHEDRON
Volume 150, Issue -, Pages -Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.tet.2023.133746
Keywords
Phosphorylthioformic acid hydrazides; Thiohydrazides; Ketones; 4-Thiadiazolines; Spiro heterocycles
Categories
Ask authors/readers for more resources
This study presents a novel and practical synthesis method for phosphorus-substituted 1,3,4-thiadiazolines using phosphorylthioformic acid hydrazides and ketones. The protocol demonstrates operational simplicity, availability of reagents, and tolerance towards different functional groups.
This study reports the first general, practical, and facile synthesis of phosphorus-substituted 1,3,4-thiadiazolines starting from phosphorylthioformic acid hydrazides and ketones. Various cyclic ketones were efficiently incorporated into spiro 1,3,4-thiadiazoline derivatives by a two-step sequence involving the heterocyclization with phosphorylthioformic acid hydrazides followed by the nitrogen acylation with acyl chlorides. The protocol is characterized by operational simplicity, readily available reagents, and functional group tolerance.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available