β-Cyclodextrin based Pickering emulsions for α-tocopherol delivery: Antioxidation stability and bioaccessibility

beta-Cyclodextrin (beta-CD) Pickering emulsion and cinnamaldehyde/beta-cyclodextrin (CIN/beta-CD) Pickering emulsion were prepared and the influences of oxidation and digestion were investigated. CIN/beta-CD composite was better dispersed at the oil-water interface than beta-CD. Hydrophobic group of CIN anchored in the oil phase and Hydrophilic hydroxyl group of beta-CD extended into the aqueous phase, which allowed CIN/beta-CD composite to be oriented at the oil-water interface and formed a more stable oil-water interface layer. beta-CD Pickering emulsion was more susceptible to oxidative deterioration than CIN/beta-CD Pickering emulsion, its malondialdehyde (MDA) value was as high as 509.41 +/- 9.37 nmol/L. Digestion experiment indicated that CIN/beta-CD Pickering emulsion was released inner oil phase in the small intestine and free fatty acid (FFA) release rate was 44.32 +/- 1.08%. Pharmacokinetic parameters manifested that alpha-tocopherol peak concentration (C-max) was 64.32 +/- 6.45 mg/L and the peak time (T-max) appeared at 5 h after administration of CIN/beta-CD Pickering emulsion.

Automated summary

In this study, beta-cyclodextrin (beta-CD) Pickering emulsion and cinnamaldehyde/beta-cyclodextrin (CIN/beta-CD) Pickering emulsion were prepared and their oxidation and digestion properties were investigated. It was found that CIN/beta-CD composite exhibited better dispersion at the oil-water interface and formed a more stable oil-water interface layer compared to beta-CD. Additionally, CIN/beta-CD Pickering emulsion showed higher resistance to oxidative deterioration compared to beta-CD Pickering emulsion.