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TRANSLATIONAL ONCOLOGY
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Ancely Ferreira dos Santos et al.
Summary: Ferroptosis, a non-apoptotic cell death modality, holds great potential as a strategy to combat therapy-resistant cancers. Cells that develop resistance to conventional therapies or metastatic cancer cells have shown increased sensitivity to ferroptosis. Therefore, studying the regulatory networks of ferroptosis in cancer and utilizing ferroptosis to enhance cancer cell sensitivity offer novel therapeutic opportunities.
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FRONTIERS IN PHARMACOLOGY
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FRONTIERS IN PHARMACOLOGY
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Chemistry, Multidisciplinary
Xuexian Fang et al.
Summary: In this study, using a mouse model of hepatic I/R injury, it is observed that glutathione (GSH) and cysteine depletion are associated with deficiency of the reducing power of nicotinamide adenine dinucleotide phosphate (NADPH). It is identified that I/R-induced hepatic ferroptosis is significantly associated with reduced expression and activity of NADP(+)-dependent malic enzyme 1 (Me1). Targeting ME1 may provide new therapeutic opportunities for I/R injury and other ferroptosis-related hepatic conditions.
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Chemistry, Multidisciplinary
Deguo Zhang et al.
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Chemistry, Multidisciplinary
Morteza Sarparast et al.
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ACS CENTRAL SCIENCE
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Medicine, General & Internal
Xiaoxia Liu et al.
Summary: In this study, it was found that fasting or a fasting-mimicking diet can effectively slow down tumor growth, but does not increase the sensitivity to apoptosis of 5-fluorouracil/oxaliplatin. During fasting, colorectal cancer cells switch from active proliferation to a slow-cycling state. Additionally, fasting-induced quiescent cells are more prone to develop drug-tolerant persister cells, leading to tumor relapse and metastasis. Fasting was also found to influence the ferroptosis pathway, which can be combined with chemotherapy to improve antitumor activity.
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Lisa Kerkhove et al.
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Biochemistry & Molecular Biology
Koung Hee Kim et al.
Summary: Polyphenols from plants such as fruits and vegetables have physiological and pharmacological activity as potential drugs to regulate oxidative stress and inflammation associated with various diseases. However, their limited solubility and bioavailability have hindered their pharmacological applications. Researchers have developed nano- and micro-carriers to enhance the drug delivery of polyphenols, maximizing their effects in terms of absorption rate, stability, cellular absorption, and bioactivity. This review focuses on the antioxidant and anti-inflammatory effects of polyphenols enhanced by drug delivery systems, particularly their inhibition of cancer cell proliferation, growth, and angiogenesis.
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Biochemistry & Molecular Biology
Li-Ming Yu et al.
Summary: This study aimed to explore the pharmacological effects of icariin on ethanol-induced atrial remodeling and the underlying mechanisms involving SIRT1 signaling. It was found that excessive ethanol administration caused significant atrial damage, which was reversed by icariin treatment. Icariin protected against atrial damage by inhibiting ferroptosis via activation of the SIRT1 signaling pathway. These findings suggest that icariin may have potential applications as a prophylactic/therapeutic drug for atrial fibrillation.
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Cell Biology
Qian Xue et al.
Summary: Ferroptosis is an iron-dependent regulated cell death characterized by lipid peroxidation and membrane damage. Copper promotes ferroptotic cell death by inducing autophagic degradation of GPX4. These findings provide new insights into the connection between metal stress and autophagy-dependent cell death.
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Medicine, Research & Experimental
Yi Xu et al.
Summary: This study demonstrated the induction of ferroptosis in BC cells by AA both in vitro and in vivo. AA showed synergistic effects with chemotherapeutic agents and inhibited the growth of BC cells. These findings suggest that AA could be a promising agent for the treatment of BC.
BIOMEDICINE & PHARMACOTHERAPY
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Biochemistry & Molecular Biology
Yunqi Jiang et al.
Summary: Ischemic heart disease is a leading cause of death worldwide. Myocardial infarction (MI) leads to cardiac damage due to cell death and insufficient cardiomyocyte self-renewal. Recent research has shown that ferroptosis, a novel type of cell death, plays a key role in cardiomyocyte death after MI. However, the regulatory mechanisms of ferroptosis and its integration into classical cell survival/death pathways are still unclear. We discovered that HIP-55, a novel adaptor protein, acts as a hub protein for the integration of the ferroptosis mechanism into the classical AKT cell survival and MAP4K1 cell death pathways for MI injury.
CELL DEATH AND DIFFERENTIATION
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Biochemistry & Molecular Biology
Di Wang et al.
Summary: This study reveals the role of SPY1 as a ferroptosis suppressor in ALS, alleviating lipid peroxidation by regulating the GCH1/BH4 axis and TFR1-induced iron to delay disease onset and improve survival. Neuron-specific overexpression of SPY1 significantly delays the occurrence and prolongs the survival in ALS transgenic mice through these pathways.
CELL DEATH AND DIFFERENTIATION
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Oncology
Zhiru Xiu et al.
Summary: The objective of this study was to investigate the effects of Esculetin on liver cancer and explore the potential mechanisms of Esculetin-induced cell death. The results showed that Esculetin significantly suppressed the proliferation, migration, and apoptosis of liver cancer cells, and influenced oxidative stress levels, autophagy, and iron metabolism in cells, leading to ferritinophagy-related phenomena. In addition, Esculetin promoted iron deposition in tumor tissues, induced tumor ferroptosis, and had an inhibitory effect on liver cancer through the NCOA4 pathway-mediated ferritinophagy.
JOURNAL OF HEPATOCELLULAR CARCINOMA
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Cell Biology
Qingyu Zhang et al.
Summary: Reprogramming of lipid metabolism affects energy utilization and cell signaling in cancer cells, contributing to cell survival and metastasis. Ferroptosis, a form of necrosis caused by lipid oxidation overload, has been implicated in cancer metastasis. However, the mechanism by which fatty acid metabolism regulates anti-ferroptosis signaling pathways is not fully understood. This study demonstrates that the formation of ovarian cancer spheroids and exposure to platinum chemotherapy increase levels of anti-ferroptosis proteins, including ACSL1. Inhibition of ferroptosis enhances spheroid formation, while genetic manipulation of ACSL1 expression reduces lipid oxidation and increases resistance to ferroptosis by modulating the myristoylation of FSP1.
CELL DEATH DISCOVERY
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Cell Biology
Xuerong Wei et al.
Summary: Cellular senescence is a state of permanent proliferation arrest in cells. Studies have shown that diabetes leads to the accumulation of senescent cells in wounds, impairing cell movement and proliferation. However, the mechanism that causes senescent cells to remain in diabetic wounds is still unclear.
CELL DEATH DISCOVERY
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Biochemistry & Molecular Biology
Shunv Cai et al.
Summary: Trabectedin induces ferroptosis in non-small cell lung cancer cells through upregulating iron, reactive oxygen species, and lipid peroxidation. This finding suggests the potential of trabectedin as an effective treatment for NSCLC.
CHEMICO-BIOLOGICAL INTERACTIONS
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Review
Pharmacology & Pharmacy
Shuai Wang et al.
Summary: This study reveals that ACYP1 plays a crucial role in the development and drug resistance of HCC by activating the MYC/LDHA axis. Targeting ACYP1 can significantly reduce lenvatinib resistance and inhibit the progression of HCC tumors with high ACYP1 expression.
DRUG RESISTANCE UPDATES
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Biochemistry & Molecular Biology
Zhao Yin et al.
Summary: It has been discovered that Nitidine Chloride (NC), an extract from Zanthoxylum nitidum, can induce cell death in multiple myeloma (MM) cells by promoting ferroptosis. The research also found that the target of NC is ABCB6 protein. Increased expression of ABCB6 in MM patients is significantly associated with MM relapse and poor prognosis. This discovery suggests that ABCB6 can be a potential therapeutic target and prognostic biomarker in MM, and NC can be a novel drug for MM treatment.
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Biochemistry & Molecular Biology
Si -Jing Jiang et al.
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FREE RADICAL BIOLOGY AND MEDICINE
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Chemistry, Medicinal
Wenjun Wang et al.
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JOURNAL OF MEDICINAL CHEMISTRY
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ACTA PHARMACOLOGICA SINICA
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Biochemistry & Molecular Biology
Wenxia Li et al.
Summary: Andrographis paniculata, a traditional Chinese medicine, has been used as a functional food in Asia. Andrographolide, a compound isolated from Andrographis paniculata, has potent anticancer activity. In this study, researchers found that Andro induced cell death in multiple myeloma (MM) cells through a type of cell death called ferroptosis, and this mechanism may provide a potential preventative and therapeutic approach for MM.
ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS
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Medicine, Research & Experimental
Jingwen Yuan et al.
Summary: Baicalin inhibits gastric cancer and enhances the efficacy of 5-Fu by promoting ROS-related ferroptosis in gastric cancer.
BIOMEDICINE & PHARMACOTHERAPY
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Chemistry, Applied
Alexandra S. Kuzmich et al.
Summary: In this study, the antiproliferative mechanisms of capsular polysaccharide from Kangiella japonica KMM 3897 were investigated in human breast carcinoma T-47D cells. The polysaccharide effectively inhibited T-47D cell proliferation by inducing G0/G1 phase arrest and mitochondrial-dependent apoptosis, and it also affected the ERK1/2 and p38 signaling pathways. These findings contribute to the understanding of the molecular mechanism of the anticancer activity of sulfated polysaccharides from marine Gram-negative bacteria.
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Cell Death & Disease
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Cell Biology
Wenhui Chen et al.
Summary: This study found that extracellular vesicles (EVs) released by nasopharyngeal carcinoma (NPC) cells can be taken up by macrophages and alter macrophage polarization. The genes SCARB1, HAAO, and CYP1B1 were identified to be involved in these regulatory functions. Moreover, SCARB1 was found to be positively associated with NPC metastasis and poor prognosis. The findings revealed that SCARB1-EVs promote metastasis by co-regulating M1 and M2 macrophage function and provide a potential therapeutic strategy for improving NPC prognosis.
CELL DEATH DISCOVERY
(2023)
Article
Multidisciplinary Sciences
Canzhang Liu et al.
Summary: The aim of this study was to investigate the protective effect of paeonol (pae) on an angiotensin II (AngII)-induced cardiac hypertrophy mouse model. The results showed that pae significantly reduced the surface area of myocardial cells and improved myocardial function. Pae protected the hearts of AngII mice by upregulating the expression of xCT and GPX4 and resisting AngII-induced ferroptosis in cardiomyocytes.
Article
Medicine, Research & Experimental
Bo Qian et al.
Summary: The phosphorylation/dephosphorylation modification of GPX4 affects ferroptosis in HCC cells, with PP2A-B55 beta playing a role in GPX4 dephosphorylation. The PP2A-B55 beta/p-GPX4(Ser2)/p53 axis is a novel regulatory pathway of Sora-induced ferroptosis. These findings have potential implications for improving the efficacy of Sora in HCC treatment.
Article
Medicine, Research & Experimental
Jie Sun et al.
Summary: Parkinson's disease (PD) is a neurodegenerative disorder characterized by the loss of midbrain dopaminergic neurons and accumulation of alpha-synuclein. This study showed that oxidative damage and reduced antioxidant enzyme GPX4 were responsible for the vulnerability of dopaminergic neurons and motor dysfunctions in PD. Iron-induced dopamine oxidation modified GPX4, leading to its degradation via the ubiquitin-proteasome pathway.
JOURNAL OF CLINICAL INVESTIGATION
(2023)
Article
Oncology
Jiayi Zang et al.
Summary: In this study, the higher expression of FSP1 and CISD1 in gastric cancer tissues was associated with poor prognosis and potential immunotherapeutic targets. They were found to promote malignant tumor progression and inhibit ferroptosis in gastric cancer.
CLINICAL & TRANSLATIONAL ONCOLOGY
(2023)
Article
Oncology
Junming Huang et al.
Summary: This study found that cinobufotalin induced ferroptosis to suppress lung cancer cell growth through the lncRNA LINC00597/hsa-miR-367-3p/TFRC pathway.
ANTI-CANCER AGENTS IN MEDICINAL CHEMISTRY
(2023)
Article
Biochemistry & Molecular Biology
Cong Zhou et al.
Summary: Timosaponin AIII (Tim-AIII) has been found to inhibit cell proliferation and migration while inducing cell death in non-small cell lung cancer (NSCLC). The mechanism involves the release of reactive oxygen species and iron accumulation, as well as the degradation of glutathione peroxidase 4 (GPX4). This study identified heat shock protein 90 (HSP90) as a direct binding target of Tim-AIII, and demonstrated that the Tim-AIII-HSP90 complex promotes GPX4 degradation, ultimately inducing ferroptosis in NSCLC cells.
INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES
(2023)
Article
Multidisciplinary Sciences
Elumalai Sanniyasi et al.
Summary: This study found that laminarin and fucoidan from brown seaweeds have anticancer activity and cytotoxicity against human liver cancer and colon cancer cells.
SCIENTIFIC REPORTS
(2023)
Article
Biochemistry & Molecular Biology
Joseph M. Hendricks et al.
Summary: This study identifies several FSP1 inhibitors through chemical screens, with FSEN1 being the most potent. The results provide new tools for exploring FSP1 as a therapeutic target and highlight the importance of combinatorial therapeutic regimes targeting FSP1 and other ferroptosis defense pathways.
CELL CHEMICAL BIOLOGY
(2023)
Article
Gastroenterology & Hepatology
Mi Yang et al.
Summary: The study revealed a novel role of Cu in promoting radioresistance in hepatocellular carcinoma (HCC) by disrupting Cu-Fe homeostasis through the inhibition of the HIF1 alpha/CP loop by COMMD10, enhancing ferroptosis and radiosensitivity.
JOURNAL OF HEPATOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Chen Zhang et al.
Summary: Ferroptosis, an iron-dependent form of cell death, plays a crucial role in tumor suppression and has the potential to reverse cancer therapy resistance.
Article
Cell Biology
Hai-Liang Zhang et al.
Summary: Through CRISPR-Cas9 and kinase inhibitor screening, Zhang et al. found that PKC beta II phosphorylates and activates ACSL4 to enhance polyunsaturated fatty acid-containing lipid biosynthesis, thereby promoting accumulation of lipid peroxidation and ferroptosis.
NATURE CELL BIOLOGY
(2022)
Article
Oncology
Olesya Vakhrusheva et al.
Summary: The therapeutic potential of artesunate (ART) on therapy-sensitive and docetaxel-resistant prostate cancer cells was investigated. The results showed that ART can inhibit the growth and proliferation of PCa cells, induce G0/G1 phase arrest, and promote cell apoptosis. Moreover, ART exhibited anticancer activity through different mechanisms in different PCa cell lines. Therefore, ART may have promise as a complementary treatment for advanced PCa.
FRONTIERS IN ONCOLOGY
(2022)
Article
Oncology
Yanqing Liu et al.
Summary: The metabolic regulation of p53 in tumor suppression is complex and diverse. It inhibits tumor development through regulating glucose, lipid, amino acid, nucleotide, iron metabolism, and ROS production.
SEMINARS IN CANCER BIOLOGY
(2022)
Article
Engineering, Biomedical
Qing Li et al.
Summary: Programmed cell death protein 1 (PD-1)/Programmed Cell Death Ligand 1 (PD-L1) blockade immunotherapy is limited by low response rates in many patients. This study developed a nanoplatform that induces immunogenic cell death and enhances tumor immunotherapy through synergistic effects with ferrotherapy. The combination of glycyrrhetinic acid-based nanomaterials and ferumoxytol improved T-cell immune response and showed potential for treating cancer.
ACTA BIOMATERIALIA
(2022)
Article
Gastroenterology & Hepatology
Byungyoon Yun et al.
Summary: This study found a significant association between long-term aspirin use and reduced HCC risk in patients with chronic HBV, and observed significant correlation in certain clinical conditions.
AMERICAN JOURNAL OF GASTROENTEROLOGY
(2022)
Article
Oncology
Sheng Zhan et al.
Summary: This study found that plumbagin inhibits glioma growth through targeting NQO1/GPX4-mediated ferroptosis, suggesting its potential as a novel inducer or candidate for anti-glioma therapy.
BRITISH JOURNAL OF CANCER
(2022)
Article
Oncology
Peng Liao et al.
Summary: T cell-derived interferon gamma (IFN γ) in combination with arachidonic acid (AA) induces immunogenic tumor ferroptosis, serving as a mechanism for CD8(+) T cell-mediated tumor killing. This process involves IFN γ stimulation of ACSL4 and alteration of tumor cell lipid pattern.
Article
Oncology
Xiuyuan Zhang et al.
Summary: This study reveals that ZNF498 is highly expressed in hepatocellular carcinoma (HCC) and is associated with advanced pathological grade and poor prognosis. ZNF498 promotes HCC initiation and progression by inhibiting p53 transcriptional activation and phosphorylation. ZNF498 also inhibits p53-mediated apoptosis and ferroptosis.
JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH
(2022)
Article
Neurosciences
Chixing Luo et al.
Summary: In this study, it was found that LINC01564 upregulates NFE2L2 expression to inhibit ferroptosis, thereby promoting temozolomide resistance in glioma cells.
MOLECULAR NEUROBIOLOGY
(2022)
Article
Cell Biology
Liang Xia et al.
Summary: In this study, the researchers investigated a new mechanism of apatinib inhibiting the proliferation of glioma cells through the induction of ferroptosis. They found that apatinib could selectively induce ferroptosis in glioma cells, but not in normal astrocytes. This effect was mediated by the inhibition of the VEGFR2/Nrf2/Keap1 pathway. Overexpression of Nrf2 could reverse the induction of ferroptosis by apatinib.
OXIDATIVE MEDICINE AND CELLULAR LONGEVITY
(2022)
Article
Plant Sciences
Feng-Guo Zhai et al.
Summary: This study evaluated the effects of red ginseng polysaccharide (RGP) in cancer cells, finding that RGP inhibited proliferation and induced ferroptosis in lung and breast cancer cells by targeting GPX4.
PHARMACEUTICAL BIOLOGY
(2022)
Article
Biotechnology & Applied Microbiology
Longlong Wu et al.
Summary: This study found that ferroptosis is involved in the ischemia-reperfusion injury (IRI) during liver transplantation (LT) using severe steatotic donor livers. The researchers also discovered that miR-124-3p in HO-1/BMMSCs-derived exosomes (HM-exos) can downregulate Steap3 expression to inhibit ferroptosis, thereby reducing graft IRI. This suggests that targeting miR-124-3p could be a promising strategy for treating IRI in steatotic grafts.
JOURNAL OF NANOBIOTECHNOLOGY
(2022)
Article
Oncology
Xiaoqiang Liang et al.
Summary: Solasonine inhibits pancreatic cancer cell progression by activating ferroptosis through inhibition of the TFAP2A/OTUB1/SLC7A11 axis.
FRONTIERS IN ONCOLOGY
(2022)
Article
Agriculture, Multidisciplinary
Junmin Xi et al.
Summary: This study isolated and characterized two compounds from an endophytic fungus and investigated the antitumor mechanism of one compound AP. The study found that AP inhibits the growth of liver cancer cells by targeting the selenoprotein thioredoxin reductase (TrxR) and ultimately induces cell apoptosis and ferroptosis.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2022)
Article
Multidisciplinary Sciences
Rina Kim et al.
Summary: Ferroptosis is a unique and targetable immunosuppressive mechanism in the tumor microenvironment, which can be pharmacologically modulated to limit tumor progression. It induces spontaneous death of PMN-MDSCs in the tumor microenvironment and limits the activity of human and mouse T cells.
Article
Cell Biology
Wei Chen et al.
Summary: Anisomycin, as an agonist of p38 MAPK, induced ferroptosis in HCC cells by promoting H3S10 phosphorylation. The study showed that anisomycin could suppress HCC cell colony formation and migration, while also inducing HCC cell death.
OXIDATIVE MEDICINE AND CELLULAR LONGEVITY
(2022)
Article
Oncology
Cuiying He et al.
Summary: This study found that kayadiol, a diterpenoid extracted from Torreya nucifera, exerted significant anticancer effects on NK/T cell lymphoma cells by inducing ferroptosis.
Article
Biochemistry & Molecular Biology
Junmin Xi et al.
Summary: The natural small molecule hinokitiol (Hino) serves as a potent ferroptosis inhibitor by chelating irons and activating Nrf2 to upregulate antioxidant genes, potentially rescuing neuronal damage in neurodegenerative disorders and alleviating paclitaxel-induced neurotoxicity without compromising its efficacy against cancer cells. These findings lay a foundation for the further development of Hino as a neuroprotective agent.
FREE RADICAL BIOLOGY AND MEDICINE
(2022)
Article
Biochemistry & Molecular Biology
Sha Liu et al.
Summary: This study reveals for the first time that EMP1 deficiency promotes bladder cancer cell migration and confers resistance to ferroptosis/oxidative stress, thus promoting bladder cancer metastasis via PPARG.
FREE RADICAL BIOLOGY AND MEDICINE
(2022)
Article
Oncology
Yuheng Hong et al.
Summary: TP53 mutations are associated with poor prognosis in DLBCL, particularly in GCB and UNC subtypes. APR-246 shows anti-tumor effects by restoring binding of mutant p53 to target genes. Mutations in exons 5, 6, and 7 of TP53 are predictors of progression and survival in DLBCL.
Article
Biochemistry & Molecular Biology
Yong Xi et al.
Summary: This study found that circBCAR3 is highly expressed in esophageal cancer and it can promote the tumorigenesis of esophageal cancer by interacting with miR-27a-3p to upregulate TNPO1. The splicing factor QKI was identified as a positive regulator of circBCAR3 and hypoxia upregulates E2F7 to transcriptionally activate QKI.
Article
Cell Biology
Kha The Nguyen et al.
Summary: This study identifies MARCHF6 as a previously unknown NADPH sensor in the ubiquitin system and a crucial regulator of ferroptosis. MARCHF6 acts as an NADPH sensor to suppress ferroptosis by enhancing the degradation of pro-ferroptosis proteins.
NATURE CELL BIOLOGY
(2022)
Article
Plant Sciences
Rui Yu et al.
Summary: The flavonoid Icariside II (ICS II) has been found to inhibit the proliferation, migration, and invasion of renal cell carcinoma (RCC) cells. This study demonstrated that ICS II induces a form of cell death called ferroptosis in RCC cells, which is accompanied by increased levels of Fe2+, MDA, and ROS, as well as decreased levels of GSH. The underlying mechanism involves the downregulation of GPX4 and the upregulation of miR-324-3p, which directly targets GPX4.
Article
Pharmacology & Pharmacy
Zhiru Xiu et al.
Summary: In this study, it was discovered that caryophyllene oxide inhibits liver cancer cells by regulating oxidative stress, autophagy, and iron metabolism, leading to ferritinophagy. It can also lower tumor volume and promote iron deposition in tumor tissue, resulting in the inhibition of tumor growth.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Engineering, Biomedical
Ruonan Zhang et al.
Summary: Curcumenol has been found to induce cell death and inhibit cell proliferation in lung cancer cells. The study also reveals that the long non-coding RNA H19 (lncRNA H19) is downregulated in lung cancer cells treated with curcumenol, and its decreased expression enhances curcumenol-induced ferroptotic cell death through the miR-19b-3p/FTH1 axis.
BIOACTIVE MATERIALS
(2022)
Article
Cell Biology
Yang Gao et al.
Summary: Targeting RRM1 promotes ferroptosis and affects the sensitivity of cancer cells to radiation and chemotherapy. RRM1 disrupts the activity and expression of antioxidant enzyme GPX4, leading to increased accumulation of reactive oxygen species and lipid peroxidation. Furthermore, targeting RRM1 also increases radiation-induced DNA damage and apoptotic signaling, causing crosstalk between ferroptosis and apoptosis.
CELL DEATH DISCOVERY
(2022)
Article
Medicine, Research & Experimental
Meng Wang et al.
Summary: This study identified the upregulation of NEAT1 in melanoma, which is closely related to cell proliferation. Downregulation of NEAT1 can suppress ferroptosis and autophagy in melanoma cells. Additionally, GNA treatment decreases the levels of NEAT1 and inhibits melanoma cell proliferation.
BIOMEDICINE & PHARMACOTHERAPY
(2022)
Article
Pharmacology & Pharmacy
Chunfeng Pan et al.
Summary: This study found that BBOX1-AS1 is highly expressed in esophageal squamous cell cancer (ESCC) and is associated with poor prognosis. Inhibiting BBOX1-AS1 can suppress cell proliferation and metastasis, and promote cell apoptosis and ferroptosis. miR-513a-3p is identified as a target of BBOX1-AS1, and its downregulation can reverse the inhibitory effect of BBOX1-AS1. Furthermore, SLC7A11 is regulated by miR-513a-3p, which is mediated by BBOX1-AS1.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Yue Li et al.
Summary: Gastrodin (GAS) from Gastrodia elata has shown ameliorative effects on cognitive dysfunction in rats with vascular dementia (VaD) by inhibiting ferroptosis through the activation of the Nrf2/Keap1-GPx4 signaling pathway. It improves learning and memory impairment and reduces oxidative stress levels.
Article
Plant Sciences
Jinxiu Li et al.
Summary: In this study, it was demonstrated that d-Borneol combined with cisplatin could enhance the antitumor activity of cisplatin and possess a certain anti-resistance ability in cisplatin-resistant non-small cell lung cancer cells. The study revealed the sensitizing effects of d-Borneol combined with cisplatin by inducing ferroptosis, promoting autophagy, and inhibiting EMT.
Article
Cell Biology
Baofu Zhang et al.
Summary: This study found that the expression of lncRNA HEPFAL is reduced in HCC tissues. HEPFAL can promote ferroptosis by reducing the expression of SLC7A11 and increasing the levels of ROS and iron. Additionally, HEPFAL increases the sensitivity of erastin-induced ferroptosis.
CELL DEATH & DISEASE
(2022)
Article
Biotechnology & Applied Microbiology
Hao Sun et al.
Summary: This study demonstrated the effectiveness of AGuIX nanoparticles in radio-sensitization of triple-negative breast cancer. It increased DNA damage level by compromising the homologous recombination repair pathway and may regulate the anti-ferroptosis system by inhibiting the NRF2-GSH-GPX4 signaling pathway.
JOURNAL OF NANOBIOTECHNOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Jun Zhang et al.
Summary: This study found that circRAPGEF5 promotes rapid proliferation and confers resistance to ferroptosis in endometrial cancer (EC) cells through its interaction with RBFOX2. These findings provide new insights into the molecular mechanism by which circRNAs regulate ferroptosis, and suggest that the circRAPGEF5/RBFOX2 splicing axis could be a promising therapeutic target for treating EC.
Article
Pharmacology & Pharmacy
Ziting Zhang et al.
Summary: This study demonstrated for the first time that Resveratrol could inhibit the growth of colon cancer cells through the ROS-dependent ferroptosis pathway and promote ferroptosis by downregulating specific proteins. Biomimetic nanocarriers were developed to improve the delivery efficiency of Resveratrol for colorectal cancer treatment.
ASIAN JOURNAL OF PHARMACEUTICAL SCIENCES
(2022)
Article
Cell Biology
Yingxiu Peng et al.
Summary: This study found that corosolic acid (CA) can sensitize liver cancer cells to ferroptosis by inhibiting HERPUD1, which reduces glutathione (GSH) synthesis. Further experiments also confirmed that CA inhibits tumor growth through HERPUD1. These findings suggest that CA is a potential treatment for liver cancer.
CELL DEATH DISCOVERY
(2022)
Article
Toxicology
Francesca V. LoBianco et al.
Summary: Hepatocellular carcinoma (HCC) is a common and deadly disease. Conventional therapeutics have limited efficacy, but research has found that parthenolide can increase the oxidation sensitivity of HCC cells, improving treatment outcomes.
FRONTIERS IN TOXICOLOGY
(2022)
Article
Medicine, General & Internal
Zhentian Ni et al.
Summary: Gastric cancer stem cells (GCSCs) are the main drivers of drug resistance, metastasis, recurrence, and poor prognosis in gastric cancer. A recent study found that Atranorin complexes can induce ferroptosis of GCSCs by inhibiting the expression of critical proteins and modifying mRNA, suggesting potential therapeutic benefits for gastric cancer.
INTERNATIONAL JOURNAL OF MEDICAL SCIENCES
(2022)
Review
Biochemistry & Molecular Biology
Fu Peng et al.
Summary: Regulated cell death (RCD), also known as programmed cell death (PCD), is a form of cell death that can be controlled by various biomacromolecules, distinct from accidental cell death (ACD). The different subroutines of RCD play crucial roles in tumorigenesis and may lead to the development of potential therapeutic strategies. Targeting the subroutines of RCD with small-molecule compounds has emerged as a promising therapeutic approach and has shown rapid progress in various types of human cancers.
SIGNAL TRANSDUCTION AND TARGETED THERAPY
(2022)
Article
Cell & Tissue Engineering
Yiqi Yang et al.
Summary: Diabetic osteoporosis (DOP) is characterized by osteocyte death through iron-dependent programmed cell death called ferroptosis. The diabetic microenvironment enhances osteocyte ferroptosis by promoting lipid peroxidation, iron overload, and aberrant activation of the ferroptosis pathway. Heme oxygenase-1 (HO-1) is upregulated in ferroptotic osteocytes in DOP, and its expression is controlled by the interaction between the transcription factors NRF2 and c-JUN. Targeting ferroptosis or HO-1 effectively rescues osteocyte death in DOP and improves trabecular deterioration.
Article
Biotechnology & Applied Microbiology
Zuli Wang et al.
Summary: Ferroptosis is primarily caused by intracellular iron activity and lipid peroxidation, while LINC00618 promotes apoptosis and ferroptosis by regulating the levels of BAX, caspase-3, ROS, and iron. LSH and SLC7A11 also play crucial roles in this process.
Article
Plant Sciences
Jian-Shu Lou et al.
Summary: The study found that ginkgetin derived from Ginkgo biloba leaves enhances DDP-induced cytotoxicity in NSCLC cells through inducing ferroptosis. The results indicate that, in addition to enhancing DDP-induced cytotoxicity, ginkgetin can disrupt redox homeostasis in DDP-treated cells and enhance apoptosis.
Article
Pharmacology & Pharmacy
Zi-Xuan Wang et al.
Summary: The study demonstrated that quercetin induces ferroptosis and apoptosis by modulating lysosome function and iron metabolism, suggesting its potential as an anti-cancer agent.
BRITISH JOURNAL OF PHARMACOLOGY
(2021)
Article
Pharmacology & Pharmacy
Ling Zhou et al.
Summary: Recent studies have shown that CBR1 is highly expressed in pancreatic cancer tissues and plays a role in regulating ROS generation and gemcitabine sensitivity. Inhibition of CBR1 by chrysin increases cellular ROS levels, leading to ferroptotic death in PC cells and enhancing sensitivity to gemcitabine. These findings suggest CBR1 as a potential therapeutic target for PC treatment and elucidate a novel mechanism underlying the anti-tumor effects of chrysin.
BIOCHEMICAL PHARMACOLOGY
(2021)
Review
Cell Biology
Daolin Tang et al.
Summary: Cell death can be executed through different subroutines, such as ferroptosis which is an iron-dependent form of non-apoptotic cell death. Ferroptosis can occur through two major pathways, driven by redox imbalance and abnormal expression of redox-active enzymes. The process is precisely regulated at multiple levels, with the transcription factor NFE2L2 playing a central role in anti-ferroptotic defense.
Article
Cell Biology
Wen-Tsan Chang et al.
Summary: Heteronemin, a marine natural product, has shown inhibitory effects on hepatocellular carcinoma cells by inducing apoptosis through modulation of ROS, MAPK signaling pathways, and other mechanisms. These findings suggest that with structural modification, heteronemin could potentially serve as a potent therapeutic agent against HCC.
OXIDATIVE MEDICINE AND CELLULAR LONGEVITY
(2021)
Article
Biochemistry & Molecular Biology
Jiang Xiaofei et al.
Summary: OA activates ferroptosis in Hela cells by promoting ACSL4 expression, reducing cell survival rate, which may be a potential approach for the treatment of cervical cancer.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2021)
Article
Oncology
Hyuna Sung et al.
Summary: The global cancer burden in 2020 saw an estimated 19.3 million new cancer cases and almost 10.0 million cancer deaths. Female breast cancer surpassed lung cancer as the most commonly diagnosed cancer, while lung cancer remained the leading cause of cancer death. These trends are expected to rise in 2040, with transitioning countries experiencing a larger increase compared to transitioned countries due to demographic changes and risk factors associated with globalization and a growing economy. Efforts to improve cancer prevention measures and provision of cancer care in transitioning countries will be crucial for global cancer control.
CA-A CANCER JOURNAL FOR CLINICIANS
(2021)
Article
Cell Biology
Yi Luo et al.
Summary: Bavachin induces ferroptosis in osteosarcoma cells through the STAT3/P53/SLC7A11 pathway, suggesting a potential new therapeutic strategy for osteosarcoma treatment.
OXIDATIVE MEDICINE AND CELLULAR LONGEVITY
(2021)
Review
Oncology
Xin Chen et al.
Summary: Ferroptosis is an iron-dependent form of regulated cell death driven by excessive lipid peroxidation, and can be induced by various agents to suppress tumor growth while also potentially triggering inflammation-associated immunosuppression. The extent of ferroptosis's impact on tumor biology and its interactions with other signaling pathways are still under investigation.
NATURE REVIEWS CLINICAL ONCOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Xiaowen Wang et al.
Summary: The study demonstrated that vitamin C can significantly inhibit the growth of anaplastic thyroid cancer cells through ferroptosis activation, involving GPX4 inactivation, ROS accumulation, and iron-dependent lipid peroxidation. The mechanism includes induction of ferritinophagy, degradation of ferritin, release of free iron, and subsequent ROS generation via Fenton reaction. This positive feedback loop sustained lipid peroxidation and led to the ferroptosis of ATC cells, providing a potential strategy for ATC therapy.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2021)
Article
Biotechnology & Applied Microbiology
Xianxian Yao et al.
Summary: Triple-negative breast cancer (TNBC) presents a challenge in terms of effective treatment. The use of ferroptosis as a novel cell death mechanism is showing promise in treating TNBC cells. The development of a ferroptosis nanomedicine using SIM loaded nanoparticles demonstrates enhanced therapeutic effects against TNBC cells.
JOURNAL OF NANOBIOTECHNOLOGY
(2021)
Article
Oncology
Zhongyuan Bao et al.
Summary: NF2 loss and low E-cadherin increase susceptibility to ferroptosis in meningioma, while MEF2C could be a potential target for inducing ferroptosis therapy in this type of tumor.
Article
Chemistry, Multidisciplinary
Shan Lu et al.
Summary: The study demonstrates that brucine inhibits glioma cell growth and induces ferroptosis by promoting the accumulation of H2O2 and iron via activation of ATF3.
ACTA PHARMACOLOGICA SINICA
(2021)
Review
Pharmacology & Pharmacy
Karolin Roemhild et al.
Summary: Iron is essential for various physiological processes, but dysregulation of iron metabolism can lead to either iron overload or deficiency, which are observed in many diseases. This article summarizes recent advancements in the pathophysiology and pharmacology of iron-overload diseases like hereditary hemochromatosis, and iron-deficiency disorders associated with anemia. Additionally, the roles of iron in immunity, its connection to cancer, and current pharmacotherapies targeting key players in iron metabolism are discussed.
TRENDS IN PHARMACOLOGICAL SCIENCES
(2021)
Article
Cell Biology
Jing Du et al.
Summary: The combination of dihydroartemisinin (DHA) and cisplatin (DDP) synergistically enhances the cytotoxicity of pancreatic ductal adenocarcinoma (PDAC) cells by inducing ferroptosis. The impairment of mitochondrial homeostasis and the accumulation of free iron and lipid peroxidation contribute to the cytotoxic effects. Pharmacological manipulation of iron levels can modulate the sensitivity of PDAC cells to DHA/DDP-induced ferroptosis. These findings suggest a promising therapeutic strategy for PDAC treatment.
CELL DEATH & DISEASE
(2021)
Article
Nutrition & Dietetics
Perrine Vermonden et al.
Summary: Plant-derived conjugated linolenic acids (CLnA), especially punicic acid (PunA) found in pomegranate seed oil, have been shown to have anti-cancer effects. PunA is highly cytotoxic to colorectal and hypopharyngeal carcinoma cells, triggering ferroptosis. Combining PunA with the known anticancer fatty acid DHA synergistically increases its cytotoxicity. This highlights the potential of using PunA as a ferroptosis-sensitizing phytochemical for cancer prevention and treatment.
Article
Biochemistry & Molecular Biology
Zhimin Tang et al.
Summary: Research has identified that oxidative stress-induced RPE degeneration is mainly regulated by HO-1-mediated ferroptosis, controlled by the Nrf2-SLC7A11-HO-1 pathway. In mouse experiments, inhibiting HO-1 can block RPE ferroptosis, and using the HO-1 inhibitor ZnPP effectively rescues RPE degeneration with superior therapeutic effects. This highlights that targeting HO-1-mediated RPE ferroptosis could serve as an effective retinal-protective strategy for preventing retinal degenerative diseases, including AMD.
Article
Biochemistry & Molecular Biology
Ruiran Wei et al.
Summary: Colorectal cancer (CRC) is a common malignant tumor and traditional treatments have limited efficacy. Ferroptosis, a form of regulated cell death dependent on iron and reactive oxygen species (ROS), has been studied as a promising way to fight against resistant cancers. This study explored the mechanism of action of tagitinin C (TC), a natural product, as a novel ferroptosis inducer in CRC cells, showing that TC induces ferroptosis through ER stress-mediated activation of the PERK-Nrf2-HO-1 signaling pathway.
INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Young-Sun Lee et al.
Article
Biochemistry & Molecular Biology
Zhenhua Guan et al.
BIOSCIENCE REPORTS
(2020)
Article
Biochemistry & Molecular Biology
Pin-Lun Lin et al.
Article
Immunology
Yu Zhang et al.
JOURNAL OF EXPERIMENTAL MEDICINE
(2020)
Article
Cell Biology
Yong Xia et al.
CELL DEATH & DISEASE
(2020)
Article
Multidisciplinary Sciences
Minghua Yang et al.
Article
Multidisciplinary Sciences
Kirill Bersuker et al.
Article
Chemistry, Multidisciplinary
Zheyu Shen et al.
Article
Biochemistry & Molecular Biology
Michael M. Gaschler et al.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2017)
Article
Biochemistry & Molecular Biology
Scott J. Dixon et al.
ACS CHEMICAL BIOLOGY
(2015)
Article
Multidisciplinary Sciences
Le Jiang et al.
Article
Oncology
Joshi J. Alumkal et al.
INVESTIGATIONAL NEW DRUGS
(2015)
Article
Biochemistry & Molecular Biology
Scott J. Dixon et al.
Article
Oncology
PJ Tobin et al.
CANCER CHEMOTHERAPY AND PHARMACOLOGY
(2006)
Review
Biochemistry & Molecular Biology
R Njalsson
CELLULAR AND MOLECULAR LIFE SCIENCES
(2005)
