The Infarct-Limiting Effect of Remote Ischemic Conditioning in Rats Is Not Affected by Aspirin

Article Cardiac & Cardiovascular Systems

Aspirin Blocks the Infarct-Size Limiting Effect of Ischemic Postconditioning in the Rat

Yochai Birnbaum et al.

Summary: Aspirin loading may explain the lack of success of ischemic postconditioning in clinical practice.

CARDIOVASCULAR DRUGS AND THERAPY (2023)

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Article Cardiac & Cardiovascular Systems

Platelet-Mediated Transfer of Cardioprotection by Remote Ischemic Conditioning and Its Abrogation by Aspirin But Not by Ticagrelor

Helmut Raphael Lieder et al.

Summary: The role of platelets during myocardial ischemia/reperfusion (I/R) is ambivalent. Remote ischemic conditioning (RIC) reduces myocardial I/R injury and platelet activation. This study found that platelets serve as carriers for RIC's cardioprotective signal and aspirin-sensitive mechanism plays a role in this process.

CARDIOVASCULAR DRUGS AND THERAPY (2023)

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Article Cardiac & Cardiovascular Systems

Remote ischaemic conditioning: defining critical criteria for success-report from the 11th Hatter Cardiovascular Workshop

R. M. Bell et al.

Summary: The Hatter Cardiovascular Institute biennial workshop focused on the future of Remote Ischaemic Conditioning (RIC), discussing the mechanisms of conditioning, the disconnect between preclinical and clinical studies, and the potential applications of RIC in other diseases. The workshop proposed specific classifications to identify responders and non-responders.

BASIC RESEARCH IN CARDIOLOGY (2022)

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Article Cardiac & Cardiovascular Systems

Effect of remote ischaemic conditioning on infarct size and remodelling in ST-segment elevation myocardial infarction patients: the CONDI-2/ERIC-PPCI CMR substudy

Rohin Francis et al.

Summary: The study found that limb remote ischaemic conditioning did not have a significant effect on myocardial infarct size and left ventricular ejection fraction. Cardiovascular magnetic resonance scans conducted both acutely and at 6 months showed no reduction in infarct size or improvement in heart function with limb RIC.

BASIC RESEARCH IN CARDIOLOGY (2021)

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Review Cardiac & Cardiovascular Systems

Protective Role of Platelets in Myocardial Infarction and Ischemia/Reperfusion Injury

Kornela Halucha et al.

Summary: Thrombotic occlusion of the coronary artery is crucial in the development of myocardial ischemia and myocardial infarction, while revascularization and antiplatelet therapies play protective roles in preventing thrombosis and ischemia/reperfusion injury. Platelets contribute to both the formation of thrombus and microthrombi, as well as to cardioprotection through the release of specific molecules and the use of antiplatelet therapy.

CARDIOLOGY RESEARCH AND PRACTICE (2021)

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Review Cardiac & Cardiovascular Systems