DLL4/Notch blockade disrupts mandibular advancement-induced condylar osteogenesis by inhibiting H-type angiogenesis

Article Dentistry, Oral Surgery & Medicine

Deferoxamine mesylate enhances mandibular advancement-induced condylar osteogenesis by promoting H-type angiogenesis

Yun Hu et al.

Summary: Through experiments, it has been proven that applying DFM can enhance MA-induced condylar osteogenesis in middle-aged mice, achieving reliable effectiveness of functional orthopaedic treatment.

JOURNAL OF ORAL REHABILITATION (2023)

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Article Dentistry, Oral Surgery & Medicine

Comparison of part-time and full-time mandibular advancement: enlightenment based on type H vessel coupling osteogenesis

Yun Hu et al.

Summary: This study compared the differences between part-time and full-time mandibular advancement (MA) appliances and aimed to promote H-type vessel coupling osteogenesis in the condylar heads. The results showed that full-time MA induced more osteogenesis and vascular structures in both volume and region.

CLINICAL ORAL INVESTIGATIONS (2023)

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Article Dentistry, Oral Surgery & Medicine

Identification of Type H Vessels in Mice Mandibular Condyle

H. Li et al.

Summary: Type H vessels, which are strongly positive for CD31 and endomucin, have been found to regulate the coupling of angiogenesis and osteogenesis in long bones. Abundant type H vessels were discovered in the subchondral bone of mouse condylar head, and their presence was positively correlated with bone formation. Deferoxamine mesylate, by activating HIF-1 alpha signaling pathways, was able to prevent osteopenia in the condyle induced by botulinum toxin type A, suggesting a potential therapeutic strategy for improving osteogenesis.

JOURNAL OF DENTAL RESEARCH (2021)

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Review Hematology