☆ 4.7 Article

Discussion on the mechanism of Lingguizhugan Decoction in treating hypertension based on network pharmacology and molecular simulation technology

JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS (2023)

Related references

Note: Only part of the references are listed.

Review Cardiac & Cardiovascular Systems

Wall shear stress and its role in atherosclerosis

Manli Zhou et al.

Summary: Atherosclerosis (AS) is a major form of cardiovascular disease with high morbidity and mortality rates globally. The development of AS is strongly influenced by hemodynamic factors, particularly wall shear stress (WSS), which can either promote or prevent AS progression. Computational fluid dynamics (CFD) modeling is used to study the characteristics of WSS, providing insights into the early lesions and vulnerable phenotypes of AS. The use of WSS as an effective parameter for early diagnosis of AS is becoming a reality and should be actively promoted in clinical practice.

FRONTIERS IN CARDIOVASCULAR MEDICINE (2023)

Add to Collection

Article Chemistry, Physical

A novel C6-sulfonated celastrol analog as a tyrosinase and melanin inhibitor: Design, synthesis, biological evaluation and molecular simulation

Jiangtao Su et al.

Summary: A novel C6-sulfonated celastrol analog (CENFN) was designed and synthesized, and its tyrosinase and melanin inhibitory effects were compared to celastrol (CE) using in silico and in vitro experiments. The results confirmed the rationality of the synthetic reactions and showed that CENFN has a higher level of tyrosinase and melanin inhibition compared to CE. These findings provide insights for the design and synthesis of celastrol analogs as tyrosinase and melanin inhibitors.

JOURNAL OF MOLECULAR STRUCTURE (2023)

Add to Collection

Review Biochemistry & Molecular Biology

Signaling pathways in vascular function and hypertension: molecular mechanisms and therapeutic interventions

Jun Ma et al.

Summary: Hypertension is a complex condition that affects vascular function and is difficult to cure due to its complex mechanisms involving multiple interactive factors. This article comprehensively reviews the signaling pathways involved in vascular function regulation and hypertension progression, including calcium pathway, NO-NOsGC-cGMP pathway, various vascular remodeling pathways, and important upstream pathways. The article also discusses the treatment methods targeting vascular function regulation and the possibility of applying these signaling pathways to clinical work.

SIGNAL TRANSDUCTION AND TARGETED THERAPY (2023)

Add to Collection

Review Pharmacology & Pharmacy

Network pharmacology: curing causal mechanisms instead of treating symptoms

Cristian Nogales et al.

Summary: For complex diseases, the traditional approach of drug discovery is highly ineffective. The shift towards systems and network medicine, along with the use of network pharmacology, revolutionizes the way we define, diagnose, and treat diseases. This approach focuses on causal, multitarget signaling modules, allowing for precise and effective therapeutic intervention through drug repurposing.

TRENDS IN PHARMACOLOGICAL SCIENCES (2022)

Add to Collection

Article Biology

Network pharmacology prediction and molecular docking-based strategy to explore the potential mechanism of Huanglian Jiedu Decoction against sepsis

Xing Li et al.

Summary: This study initially clarifies the potential mechanism of Huanglian Jiedu Decoction (HLJDD) in the treatment of sepsis using network pharmacology and molecular docking techniques. The study reveals the active ingredients and signaling pathways involved in HLJDD treatment, providing a reference for subsequent research.

COMPUTERS IN BIOLOGY AND MEDICINE (2022)

Add to Collection

Article Integrative & Complementary Medicine

Mining Important Herb Combinations of Traditional Chinese Medicine against Hypertension Based on the Symptom-Herb Network Combined with Network Pharmacology

Zhenhai Sun et al.

Summary: This study analyzes the prescription rules of famous old traditional Chinese medicine experts for treating hypertension using data mining methods. A basic prescription was identified and its rationality was verified through network pharmacology analysis. The findings provide new approaches for the inheritance of academic experience and the development of new drugs.

EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE (2022)

Add to Collection

Article Chemistry, Analytical

Integrated metabolomics and mechanism to reveal the protective effect of kaempferol on pulmonary arterial hypertension

Jie Yi et al.

Summary: This study found that kaempferol has significant effects on pulmonary arterial hypertension (PAH), improving right ventricular function and alleviating disease progression. It acts through regulating abnormal autophagy and metabolic disorders, providing a new perspective for the treatment of PAH.

JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS (2022)

Add to Collection

Article Physiology

Naringenin Protects against Hypertension by Regulating Lipid Disorder and Oxidative Stress in a Rat Model

Hui Liu et al.

Summary: Naringenin improves obesity-associated hypertension by regulating lipid disorder and oxidative stress.

KIDNEY & BLOOD PRESSURE RESEARCH (2022)

Add to Collection

Review Immunology

Deeper insight into the role of IL-17 in the relationship beween hypertension and intestinal physiology

Ze-Jun Yang et al.

Summary: With the increasing incidence of hypertension worldwide, the relationship between intestinal microbiota and hypertension has gained significant attention. However, the associations between hypertension and a large number of immune factors have not been fully characterized. This review provides a detailed description of the role of IL-17 in the pathology of hypertension, including the underlying mechanisms and clinical implications.

JOURNAL OF INFLAMMATION-LONDON (2022)

Add to Collection

Article Biochemistry & Molecular Biology

RCSB Protein Data bank: Tools for visualizing and understanding biological macromolecules in 3D

Stephen K. Burley et al.

Summary: The Protein Data Bank (PDB) is an open-access global archive that houses three-dimensional biomolecular structure data. It is jointly managed by the Worldwide Protein Data Bank (wwPDB) partnership. The Research Collaboratory for Structural Bioinformatics Protein Data Bank (RCSB PDB) serves as the US data center for wwPDB and is responsible for processing and ensuring the security of PDB data. It provides free access to PDB data and supports training and education through its web portals.

PROTEIN SCIENCE (2022)

Add to Collection

Review Cardiac & Cardiovascular Systems

Effectiveness and safety of Linggui Zhugan decoction for the treatment of premature contraction in patients with coronary heart disease: A systematic review and meta-analysis

Longkun Liu et al.

Summary: This study evaluated the effectiveness and safety of Linggui Zhugan decoction (LZD) as an adjunct treatment for premature contraction in patients with coronary heart disease. The results showed that LZD combined with conventional antiarrhythmic drugs could increase clinical effectiveness and reduce the number of premature junctional beats in 24 hours compared to conventional antiarrhythmic drugs alone. There were no significant differences in adverse reactions.

FRONTIERS IN CARDIOVASCULAR MEDICINE (2022)

Add to Collection

Review Oncology

Repurposing of drugs as STAT3 inhibitors for cancer therapy

Pathum S. Thilakasiri et al.

Summary: Drug repurposing is a valuable approach for rapidly introducing new cancer therapies into clinical practice. STAT3 inhibitors play a significant role in cancer treatment, but challenges remain in understanding the mechanisms of STAT3 activation and developing strategies to suppress its activity with various pharmaceutical agents.

SEMINARS IN CANCER BIOLOGY (2021)

Add to Collection

Review Cardiac & Cardiovascular Systems

Role of Lipid Accumulation and Inflammation in Atherosclerosis: Focus on Molecular and Cellular Mechanisms

Khojasteh Malekmohammad et al.

Summary: Atherosclerosis is a chronic inflammatory disease driven by lipid accumulation, especially low-density lipoprotein, and dysfunction of lipid homeostasis. Inflammation plays a key role in all phases of atherosclerosis, while lipid metabolism and inflammatory pathways interact closely with each other. Studies have shown that microRNAs and lncRNAs also have important regulatory roles in the pathophysiology of atherosclerosis.

FRONTIERS IN CARDIOVASCULAR MEDICINE (2021)

Add to Collection

Review Urology & Nephrology

Contribution of Th17 cells to tissue injury in hypertension

David P. Basile et al.

Summary: Recent studies have found that Th17 cells, as part of the adaptive immune system, play a role in hypertension and renal tissue damage. The activity of these cells may be influenced by physiological factors associated with hypertension, potentially exacerbating inflammation and renal fibrosis through multiple cellular mechanisms.

CURRENT OPINION IN NEPHROLOGY AND HYPERTENSION (2021)

Add to Collection

Article Integrative & Complementary Medicine

Phytochemical Analysis Using UPLC-MS/MS Combined with Network Pharmacology Methods to Explore the Biomarkers for the Quality Control of Lingguizhugan Decoction

Baolin Li et al.

Summary: The study identified active ingredients of Lingguizhugan decoction using UPLC-MS/MS and network pharmacology. A total of 149 compounds were preliminarily identified, with 20 chemical constituents selected as biomarkers. The methodological results indicated satisfactory linearity, stability, precision, repeatability, and recovery of the method.

EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE (2021)

Add to Collection

Article Chemistry, Physical

gmx_MMPBSA: A New Tool to Perform End-State Free Energy Calculations with GROMACS

Mario S. Valdes-Tresanco et al.

Summary: gmx_MMPBSA is a new tool for performing end-state free energy calculations from GROMACS molecular dynamics trajectories, offering various options including binding free energy calculations with different solvation models, stability calculations, computational alanine scanning, entropy corrections, and binding free energy decomposition. Additionally, promising methodologies for calculating relative binding free energies have been implemented.

JOURNAL OF CHEMICAL THEORY AND COMPUTATION (2021)

Add to Collection

Review Biochemistry & Molecular Biology

New drug targets for hypertension: A literature review

Qiannan Gao et al.

Summary: Hypertension is a common cardiovascular disease globally, with resistant hypertension being difficult to control effectively. Current antihypertensive drugs may have adverse effects, highlighting the need for new therapeutic targets and treatments to manage hypertension and its comorbidities.

BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE (2021)

Add to Collection

Review Peripheral Vascular Disease

Interleukin 17A: Key Player in the Pathogenesis of Hypertension and a Potential Therapeutic Target

Gwendolyn K. Davis et al.

Summary: IL-17A plays a key role in the pathogenesis of hypertension, promoting blood pressure increase through various mechanisms and contributing to renal and vascular dysfunction. Therapeutics targeting IL-17A show promise in both animal models and human studies for the treatment of hypertension.

CURRENT HYPERTENSION REPORTS (2021)

Add to Collection

Review Clinical Neurology

Matrix metalloproteinase-9 as a messenger in the cross talk between obstructive sleep apnea and comorbid systemic hypertension, cardiac remodeling, and ischemic stroke: a literature review

Saif Mashaqi et al.

Summary: This study investigates the role of MMP-9 in OSA and cardiovascular diseases, emphasizing its importance as an inflammatory mediator in these conditions.

JOURNAL OF CLINICAL SLEEP MEDICINE (2021)

Add to Collection

Article Cell Biology

Pyrogallol-Phloroglucinol-6 6-Bieckol on Attenuates High-Fat Diet-Induced Hypertension by Modulating Endothelial-to-Mesenchymal Transition in the Aorta of Mice

Myeongjoo Son et al.

Summary: Endothelial-to-mesenchymal transition (EndMT) plays a role in various cardiovascular diseases and is induced by dyslipidemia or obesity. In this study, the compound pyrogallol-phloroglucinol-6,6-bieckol (PPB) extracted from Ecklonia cava was found to attenuate EndMT and reduce blood pressure in a high-fat diet-fed animal model. PPB also decreased intima-media thickness, reversed the upregulation of various signaling pathways, and showed potential in addressing hypertension induced by high-fat diets.

OXIDATIVE MEDICINE AND CELLULAR LONGEVITY (2021)

Add to Collection

Article Multidisciplinary Sciences

Network pharmacology-based investigation of potential targets of astragalus membranaceous-angelica sinensis compound acting on diabetic nephropathy

Youzi Dong et al.

Summary: This study used network pharmacology and molecular docking to explore the mechanism of the Astragalus membranaceous (AM)-Angelica sinensis (AS) compound in the treatment of diabetic nephropathy (DN). The results suggest that the compound may treat DN by regulating various biological processes.

SCIENTIFIC REPORTS (2021)

Add to Collection

Review Health Care Sciences & Services

Clinical effects of Lingguizhugan decoction in the treatment of hypertension: a systematic review and meta-analysis

Pingchang Xie et al.

Summary: The study revealed that Lingguizhugan decoction combined with western medicine showed superior effects in treating hypertension by significantly reducing blood pressure and decreasing adverse reactions among patients. Further large sample and multi-center controlled trials are needed to validate these findings due to limitations in the quantity and quality of included studies.

ANNALS OF PALLIATIVE MEDICINE (2021)

Add to Collection

Article Medicine, General & Internal

Naringenin prevents pregnancy-induced hypertension via suppression of JAK/STAT3 signalling pathway in mice

Bide Duan et al.

Summary: Naringenin significantly reduced blood pressure, total urine protein level, plasma levels of VCE, alpha-ADR, and angiotensin in PIH mice. It also decreased pro-inflammatory cytokines and oxidative stress markers while increasing anti-inflammatory cytokine levels. Naringenin inhibited JAK2/STAT3 signalling by promoting SHP-1 expression, contributing to the improvement of hypertension in pregnancy.

INTERNATIONAL JOURNAL OF CLINICAL PRACTICE (2021)

Add to Collection

Article Oncology

Inhibitory effects of formononetin on the monocrotaline-induced pulmonary arterial hypertension in rats

Yonghui Wu et al.

MOLECULAR MEDICINE REPORTS (2020)

Add to Collection

Article Biochemistry & Molecular Biology

Connexin43 and zonula occludens-1 are targets of Akt in cardiomyocytes that correlate with cardiac contractile dysfunction in Akt deficient hearts

Sangmi Ock et al.

BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE (2018)

Add to Collection

Review Integrative & Complementary Medicine

Pharmacological Effect of Quercetin in Hypertension and Its Potential Application in Pregnancy-Induced Hypertension: Review of In Vitro, In Vivo, and Clinical Studies

Marcin Ozarowski et al.

EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE (2018)

Add to Collection

Review Biochemistry & Molecular Biology

Actions of Quercetin, a Polyphenol, on Blood Pressure

Yoshinori Marunaka et al.

MOLECULES (2017)

Add to Collection

Review Peripheral Vascular Disease

Do Advanced Glycation End Products and Its Receptor Play a Role in Pathophysiology of Hypertension?

Kailash Prasad et al.

INTERNATIONAL JOURNAL OF ANGIOLOGY (2017)

Add to Collection

Review Medicine, Research & Experimental

Endothelial fluid shear stress sensing in vasculr health and disease

Nicolas Baeyens et al.

JOURNAL OF CLINICAL INVESTIGATION (2016)

Add to Collection

Review Pharmacology & Pharmacy

The MM/PBSA and MM/GBSA methods to estimate ligand-binding affinities

Samuel Genheden et al.

EXPERT OPINION ON DRUG DISCOVERY (2015)

Add to Collection

Article Biochemical Research Methods

Detection and Chemical Profiling of Ling-Gui-Zhu-Gan Decoction by Ultra Performance Liquid Chromatography-Hybrid Linear Ion Trap-Orbitrap Mass Spectrometry

Pei Wang et al.

JOURNAL OF CHROMATOGRAPHIC SCIENCE (2015)

Add to Collection

Article Biochemistry & Molecular Biology

OMIM.org: Online Mendelian Inheritance in Man (OMIM®), an online catalog of human genes and genetic disorders

Joanna S. Amberger et al.

NUCLEIC ACIDS RESEARCH (2015)

Add to Collection

Article Mathematical & Computational Biology

cytoHubba: identifying hub objects and sub-networks from complex interactome

Chia-Hao Chin et al.

BMC SYSTEMS BIOLOGY (2014)

Add to Collection

Article Neurosciences

Receptor for AGEs (RAGE) as Mediator of NF-kB Pathway Activation in Neuroinflammation and Oxidative Stress

Julio C. Tobon-Velasco et al.

CNS & NEUROLOGICAL DISORDERS-DRUG TARGETS (2014)

Add to Collection

Article Peripheral Vascular Disease

Early Interference With p44/42 Mitogen-Activated Protein Kinase Signaling in Hypothalamic Paraventricular Nucleus Attenuates Angiotensin II-Induced Hypertension

Yang Yu et al.

HYPERTENSION (2013)

Add to Collection

Article Chemistry, Medicinal

Assessing the Performance of the MM/PBSA and MM/GBSA Methods. 1. The Accuracy of Binding Free Energy Calculations Based on Molecular Dynamics Simulations

Tingjun Hou et al.

JOURNAL OF CHEMICAL INFORMATION AND MODELING (2011)

Add to Collection

Article Biochemistry & Molecular Biology

STRING 8-a global view on proteins and their functional interactions in 630 organisms

Lars J. Jensen et al.

NUCLEIC ACIDS RESEARCH (2009)

Add to Collection

Review Chemistry, Multidisciplinary

GROMACS: Fast, flexible, and free

D Van der Spoel et al.

JOURNAL OF COMPUTATIONAL CHEMISTRY (2005)

Add to Collection

© Peeref 2019-2024. All rights reserved.