☆ 4.5 Review

Targeting ferroptosis: New perspectives of Chinese herbal medicine in the treatment of diabetes and its complications

HELIYON (2023)

Related references

Note: Only part of the references are listed.

Review Biochemistry & Molecular Biology

Nrf2 signaling in diabetic nephropathy, cardiomyopathy and neuropathy: Therapeutic targeting, challenges and future prospective

Mehrdad Hashemi et al.

Summary: The Western lifestyle has led to an increase in metabolic anomalies such as diabetes mellitus (DM) and obesity. DM has rapidly grown worldwide, affecting individuals in both developing and developed countries, and is associated with complications like diabetic nephropathy (DN), diabetic cardiomyopathy (DC), and diabetic neuropathy. Dysregulation of Nrf2 signaling, which regulates cellular redox balance and activates antioxidant enzymes, has been observed in DM and other human diseases. This review discusses the role of Nrf2 signaling in major diabetic complications and the potential of targeting Nrf2 for treatment. These complications share similarities including oxidative stress, inflammation, and fibrosis and activating Nrf2 signaling can help reduce inflammation, oxidative damage, and interstitial fibrosis in diabetic complications. Pathways like SIRT1 and AMPK can upregulate Nrf2 expression in the amelioration of DN, DC, and diabetic neuropathy. Additionally, therapeutic agents like resveratrol and curcumin have been used to promote Nrf2 expression and combat oxidative stress in DM.

BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE (2023)

Add to Collection

Article Medicine, Research & Experimental

δ-Tocotrienol in Combination with Resveratrol Improves the Cardiometabolic Risk Factors and Biomarkers in Patients with Metabolic Syndrome: A Randomized Controlled Trial

Safia Fatima et al.

Summary: The study found that supplementation of delta-tocotrienol and resveratrol mixture (TRM) improved cardiometabolic risk factors and biomarkers of inflammation and oxidative stress in patients with metabolic syndrome.

METABOLIC SYNDROME AND RELATED DISORDERS (2023)

Add to Collection

Article Pharmacology & Pharmacy

Broadening horizons in mechanisms, management, and treatment of diabetic kidney disease

Adriana Petrazzuolo et al.

Summary: Diabetic kidney disease (DKD) is the leading cause of end-stage kidney disease in diabetic patients, with its prevalence increasing globally. It is characterized by histological alterations primarily affecting the glomerular filtration unit, resulting in urinary albumin-to-creatinine ratio elevation and estimated glomerular filtration rate reduction. This review highlights recent advances in understanding the cellular and molecular mechanisms underlying DKD and discusses potential therapeutic targets for future applications.

PHARMACOLOGICAL RESEARCH (2023)

Add to Collection

Article Urology & Nephrology

Neuroblastoma suppressor of tumorigenicity 1 is associated with the severity of interstitial fibrosis and kidney function decline in IgA nephropathy

Hiroki Kobayashi et al.

Summary: Recent studies have found a strong association between circulating neuroblastoma suppressor of tumorigenicity 1 (NBL1) and kidney disease progression in patients with diabetic kidney disease. This study aimed to investigate the association of serum NBL1 level with kidney function and renal histological findings in patients with IgA nephropathy. The results showed that serum NBL1 level was significantly associated with tubular atrophy/interstitial fibrosis and kidney disease progression in patients with newly diagnosed IgA nephropathy.

JOURNAL OF NEPHROLOGY (2023)

Add to Collection

Article Biochemistry & Molecular Biology

A Novel Identified Circular RNA, mmu_mmu_circRNA_0000309, Involves in Germacrone-Mediated Improvement of Diabetic Nephropathy Through Regulating Ferroptosis by Targeting miR-188-3p/GPX4 Signaling Axis

Juan Jin et al.

Summary: This study found that germacrone can improve kidney damage and inhibit podocyte apoptosis in diabetic nephropathy (DN) mice. Silencing mmu_circRNA_0000309 weakens the anti-apoptotic and anti-injury effects of germacrone, leading to aggravation of mitochondrial damage and ferroptosis. mmu_circRNA_0000309 competitively sponges miR-188-3p and subsequently promotes GPX4 expression, thereby deactivating ferroptosis-dependent mitochondrial damage and podocyte apoptosis.

ANTIOXIDANTS & REDOX SIGNALING (2022)

Add to Collection

Article Cell Biology

Activation of NRF2/FPN1 pathway attenuates myocardial ischemia-reperfusion injury in diabetic rats by regulating iron homeostasis and ferroptosis

Hao Tian et al.

Summary: This study investigates the effects of iron homeostasis and ferroptosis on myocardial ischemia-reperfusion injury in diabetic patients. The NRF2/FPN1 pathway may play a promising role in the treatment of diabetic myocardial ischemia-reperfusion injury.

CELL STRESS & CHAPERONES (2022)

Add to Collection

Article Endocrinology & Metabolism

IDF Diabetes Atlas: Global, regional and country-level diabetes prevalence estimates for 2021 and projections for 2045

Hong Sun et al.

Summary: This study provides global, regional, and country-level estimates of diabetes prevalence and health expenditures for 2021 and projections for 2045. The global prevalence of diabetes is increasing and is expected to have the greatest relative increase in middle-income countries. Diabetes-related health expenditures are also projected to rise.

DIABETES RESEARCH AND CLINICAL PRACTICE (2022)

Add to Collection

Article Biochemistry & Molecular Biology

Activation of osteoblast ferroptosis via the METTL3/ASK1-p38 signaling pathway in high glucose and high fat (HGHF)-induced diabetic bone loss

Youfen Lin et al.

Summary: High glucose and high fat may induce ferroptosis in osteoblasts, leading to diabetic osteoporosis through activation of the METTL3/ASK1-p38 signaling pathway. Inhibition of ferroptosis in osteoblasts may provide a potential therapeutic strategy for diabetic osteoporosis.

FASEB JOURNAL (2022)

Add to Collection

Article Biochemistry & Molecular Biology

Mitochondrial Ferritin Deficiency Promotes Osteoblastic Ferroptosis Via Mitophagy in Type 2 Diabetic Osteoporosis

XinDong Wang et al.

Summary: The incidence of type 2 diabetic osteoporosis (T2DOP) is rapidly increasing and its specific mechanism remains unclear. Studies have shown a relationship between iron overload and T2DOP. Mitochondrial ferritin (FtMt) may inhibit ferroptosis in osteoblasts by reducing oxidative stress caused by excess ferrous ions, while FtMt deficiency induces mitophagy in the pathogenesis of T2DOP. FtMt could potentially serve as a target for T2DOP therapy.

BIOLOGICAL TRACE ELEMENT RESEARCH (2022)

Add to Collection

Article Gastroenterology & Hepatology

Combined berberine and probiotic treatment as an effective regimen for improving postprandial hyperlipidemia in type 2 diabetes patients: a double blinded placebo controlled randomized study

Shujie Wang et al.

Summary: This study aimed to evaluate the effectiveness of combining probiotics and berberine (BBR) in reducing postprandial lipidemia (PL) in type 2 diabetes (T2D) patients and explore the underlying mechanism. The results showed that the combined therapy was superior to individual treatments in improving postprandial total cholesterol and low-density lipoprotein cholesterol levels. Changes in gut microbiota were associated with this effect.

GUT MICROBES (2022)

Add to Collection

Article Food Science & Technology

Umbelliferone delays the progression of diabetic nephropathy by inhibiting ferroptosis through activation of the Nrf-2/HO-1 pathway

Tong Jin et al.

Summary: The findings suggest that umbelliferone has a protective effect on diabetic nephropathy by activating the Nrf2/HO-1 pathway and attenuating high glucose-induced ferroptosis.

FOOD AND CHEMICAL TOXICOLOGY (2022)

Add to Collection

Article Biochemistry & Molecular Biology

NAC alleviative ferroptosis in diabetic nephropathy via maintaining mitochondrial redox homeostasis through activating SIRT3-SOD2/Gpx4 pathway

Quanwei Li et al.

Summary: The study investigated the effect of NAC combined with insulin treatment on diabetic nephropathy, showing that NAC attenuated ferroptosis in DN by activating the SIRT3-SOD2-Gpx4 signaling pathway.

FREE RADICAL BIOLOGY AND MEDICINE (2022)

Add to Collection

Article Cell Biology

A novel miR-338-3p/SLC1A5 axis reprograms retinal pigment epithelium to increases its resistance to high glucose-induced cell ferroptosis

Jing Zhou et al.

Summary: This study revealed the molecular mechanisms underlying oxidative stress-induced cell ferroptosis during the pathogenesis of diabetic retinopathy. Targeting the miR-338-3p/SLC1A5 axis can block high glucose-induced cell ferroptosis.

JOURNAL OF MOLECULAR HISTOLOGY (2022)

Add to Collection

Article Biochemistry & Molecular Biology

Liraglutide Alleviates Cognitive Deficit in db/db Mice: Involvement in Oxidative Stress, Iron Overload, and Ferroptosis

Ji-Ren An et al.

Summary: Studies have shown that liraglutide has a superior efficacy in improving cognitive impairment associated with diabetes, reducing oxidative stress, lipid peroxidation, and iron overload, inhibiting ferroptosis, and ultimately restoring cognitive function.

NEUROCHEMICAL RESEARCH (2022)

Add to Collection

Article Biochemistry & Molecular Biology

Glabridin, a bioactive component of licorice, ameliorates diabetic nephropathy by regulating ferroptosis and the VEGF/Akt/ERK pathways

Hongtao Tan et al.

Summary: Through network pharmacology, the study revealed the protective effects of Glab on diabetic nephropathy, possibly by suppressing ferroptosis and the VEGF/Akt/ERK pathway.

MOLECULAR MEDICINE (2022)

Add to Collection

Article Plant Sciences

Calycosin plays a protective role in diabetic kidney disease through the regulation of ferroptosis

Di Huang et al.

Summary: This study found that calycosin has a protective effect on diabetic kidney disease, possibly through the inhibition of ferroptosis.

PHARMACEUTICAL BIOLOGY (2022)

Add to Collection

Article Biotechnology & Applied Microbiology

Platycodin D regulates high glucose-induced ferroptosis of HK-2 cells through glutathione peroxidase 4 (GPX4)

Jinzhong Huang et al.

Summary: This study found that Platycodin D (PD) inhibited ferroptosis in high glucose-induced HK-2 cells by upregulating GPX4 expression. This suggests that PD may be an effective drug for the clinical treatment of diabetic nephropathy.

BIOENGINEERED (2022)

Add to Collection

Article Biotechnology & Applied Microbiology

Downregulation of fatty acid binding protein 4 alleviates lipid peroxidation and oxidative stress in diabetic retinopathy by regulaging peroxisome proliferator-activated receptor γ-mediated ferroptosis

Xiao'e Fan et al.

Summary: The study investigates the role of FABP4 in diabetic retinopathy (DR) and its regulation mechanism. Through mouse and cell models, it is found that inhibiting FABP4 can alleviate the development of DR and reduce lipid peroxidation and oxidative stress through regulating the PPARy-mediated ferroptosis pathway.

BIOENGINEERED (2022)

Add to Collection

Article Biotechnology & Applied Microbiology

Astragaloside-IV alleviates high glucose-induced ferroptosis in retinal pigment epithelial cells by disrupting the expression of miR-138-5p/Sirt1/Nrf2

Xuyuan Tang et al.

Summary: This study demonstrates that AS-IV can alleviate the damage to RPE cells in diabetic retinopathy. The protective effect of AS-IV is mediated through the regulation of the mir-138-5p/Sirt1/Nrf2 pathway, which enhances the cellular antioxidant capacity and alleviates ferroptosis, ultimately leading to decreased cell death and potentially inhibiting the pathological process of DR.

BIOENGINEERED (2022)

Add to Collection

Article Biochemistry & Molecular Biology

Glia maturation factor-β induces ferroptosis by impairing chaperone-mediated autophagic degradation of ACSL4 in early diabetic retinopathy

Caiying Liu et al.

Summary: Diabetic retinopathy (DR) is a major cause of blindness, and timely prevention and treatment are crucial. This study found that the neurodegenerative factor GMFB is upregulated in the early stages of diabetes and plays a role in the pathogenesis of the disease. In a high glucose environment, GMFB secretion in the vitreous affects lysosome function, autophagy, and ferroptosis, leading to abnormalities in the degradation process and the accumulation of lethal lipid species in the retinal pigment epithelial cells. Targeting GMFB and related pathways could be a new therapeutic strategy for DR.

REDOX BIOLOGY (2022)

Add to Collection

Review Biochemistry & Molecular Biology

Ferroptosis turns 10: Emerging mechanisms, physiological functions, and therapeutic applications

Brent R. Stockwell

Summary: This review describes the key regulators of ferroptosis and provides an overview of metabolism, ROS biology, and iron biology. Additionally, it highlights the important concepts and unanswered questions in the field of ferroptosis. The future holds promise for further breakthroughs in understanding the mechanisms of ferroptosis and utilizing it for therapeutic purposes.

CELL (2022)

Add to Collection

Article Endocrinology & Metabolism

Targeting ferroptosis with miR-144-3p to attenuate pancreatic β cells dysfunction via regulating USP22/SIRT1 in type 2 diabetes

Shanshan Zhang et al.

Summary: This study found that Ferroptosis occurred in T2DM and investigated its mechanisms. The up-regulation of miR-144-3p suppressed USP22/SIRT1, leading to Ferroptosis and subsequent dysfunction of pancreatic beta cells, thereby promoting the development of T2DM.

DIABETOLOGY & METABOLIC SYNDROME (2022)

Add to Collection

Article Endocrinology & Metabolism

The effect of berberine and fenugreek seed co-supplementation on inflammatory factor, lipid and glycemic profile in patients with type 2 diabetes mellitus: a double-blind controlled randomized clinical trial

Shima Nematollahi et al.

Summary: This study found that co-supplementation of berberine and fenugreek seed can improve cardio-metabolic status in patients with type 2 diabetes mellitus and support the anti-diabetic and anti-inflammatory role of herb in the improvement of quality of life.

DIABETOLOGY & METABOLIC SYNDROME (2022)

Add to Collection

Article Biochemistry & Molecular Biology

ZIP14 is involved in iron deposition and triggers ferroptosis in diabetic nephropathy

Keping Wu et al.

Summary: The study reveals the important role of ZIP14 in ferroptosis-mediated diabetic kidney injury, showing that it can improve kidney function by regulating ferrous iron and oxidative stress levels, providing a potential new therapeutic approach for the treatment of diabetic nephropathy.

METALLOMICS (2022)

Add to Collection

Article Nutrition & Dietetics

Evaluation and Screening of Hypoglycemic Activity of Total Ginsenosides GBE-5 Fraction From Panax Ginseng Berry Based on UHPLC-MS Metabolomics

Heyu Wang et al.

Summary: This study evaluated the effective components of ginseng berry and found that the GBE-5 fraction had better hypoglycemic activity. The main metabolic pathways involved in the regulation of hypoglycemic activity were identified as arachidonic acid metabolism, linoleic acid metabolism, unsaturated fatty acid biosynthesis, and ferroptosis.

FRONTIERS IN NUTRITION (2022)

Add to Collection

Article Cell & Tissue Engineering

Targeting ferroptosis suppresses osteocyte glucolipotoxicity and alleviates diabetic osteoporosis

Yiqi Yang et al.

Summary: Diabetic osteoporosis (DOP) is characterized by osteocyte death through iron-dependent programmed cell death called ferroptosis. The diabetic microenvironment enhances osteocyte ferroptosis by promoting lipid peroxidation, iron overload, and aberrant activation of the ferroptosis pathway. Heme oxygenase-1 (HO-1) is upregulated in ferroptotic osteocytes in DOP, and its expression is controlled by the interaction between the transcription factors NRF2 and c-JUN. Targeting ferroptosis or HO-1 effectively rescues osteocyte death in DOP and improves trabecular deterioration.

BONE RESEARCH (2022)

Add to Collection

Article Medicine, Research & Experimental

Therapeutic effects of Chinese herbal medicines and their extracts on diabetes

Jie Sun et al.

Summary: With the improvement of people's living standards and changes in the environment, the incidence of diabetes has rapidly increased, becoming one of the main diseases threatening the health of modern people. Although existing treatment methods can control symptoms and delay disease progression, they have not significantly improved quality of life for patients. Chinese herbal medicines and their extracts, combining traditional experience with modern scientific research, are expected to bring a qualitative leap in the clinical management of diabetes.

BIOMEDICINE & PHARMACOTHERAPY (2021)

Add to Collection

Article Food Science & Technology

Epicatechin and quercetin exhibit in vitro antioxidant effect, improve biochemical parameters related to metabolic syndrome, and decrease cellular genotoxicity in humans

Aldo Leyva-Soto et al.

Summary: Metabolic syndrome, a condition with increasing incidence globally, is associated with chronic diseases. A study showed that consuming enriched bread with a mixture of (-)-epicatechin and quercetin can improve biochemical parameters related to metabolic syndrome and decrease cell abnormalities in patients.

FOOD RESEARCH INTERNATIONAL (2021)

Add to Collection

Article Cell Biology

Long noncoding RNA Meg3 mediates ferroptosis induced by oxygen and glucose deprivation combined with hyperglycemia in rat brain microvascular endothelial cells, through modulating the p53/GPX4 axis

Cheng Chen et al.

Summary: This study revealed that the long non-coding RNA Meg3 mediated ferroptosis in rat brain microvascular endothelial cells (RBMVECs) upon injury induced by oxygen-glucose deprivation (OGD) and hyperglycemia by modulating the p53 signaling pathway.

EUROPEAN JOURNAL OF HISTOCHEMISTRY (2021)

Add to Collection

Article Oncology

TRIM46 contributes to high glucose-induced ferroptosis and cell growth inhibition in human retinal capillary endothelial cells by facilitating GPX4 ubiquitination

Jingfa Zhang et al.

Summary: The increased permeability of retinal capillary endothelial cells is a key feature in the progression of diabetic retinopathy. Mechanistic insights into the involvement of TRIM46 and GPX4 in regulating ferroptosis of HRCECs provide potential therapeutic targets for the treatment of DR.

EXPERIMENTAL CELL RESEARCH (2021)

Add to Collection

Article Cell Biology

Inhibition of the long non-coding RNA ZFAS1 attenuates ferroptosis by sponging miR-150-5p and activates CCND2 against diabetic cardiomyopathy

Tingjuan Ni et al.

Summary: The study investigated the role of lncRNA-ZFAS1 in diabetic cardiomyopathy (DbCM) and found that ZFAS1 acts as a ceRNA to sponge miR-150-5p and downregulate CCND2 to promote cardiomyocyte ferroptosis and DbCM development. Inhibition of ZFAS1 could be a promising therapeutic target for the treatment and prevention of DbCM.

JOURNAL OF CELLULAR AND MOLECULAR MEDICINE (2021)

Add to Collection

Article Endocrinology & Metabolism

Role of ferroptosis in the process of diabetes-induced endothelial dysfunction

Er-Fei Luo et al.

Summary: Ferroptosis is involved in endothelial dysfunction caused by diabetes, with activation of the p53-xCT-GSH axis playing a crucial role in endothelial cell ferroptosis and dysfunction.

WORLD JOURNAL OF DIABETES (2021)

Add to Collection

Article Biochemistry & Molecular Biology

HMGB1 regulates ferroptosis through Nrf2 pathway in mesangial cells in response to high glucose

You Wu et al.

Summary: This study demonstrated that HMGB1 regulates glucose-induced ferroptosis via Nrf2 pathway in mesangial cells, suggesting its therapeutic potential in diabetic kidney disease.

BIOSCIENCE REPORTS (2021)

Add to Collection

Article Neurosciences

SLC40A1 Mediates Ferroptosis and Cognitive Dysfunction in Type 1 Diabetes

Lijun Hao et al.

Summary: Cognitive dysfunction often accompanies diabetes, and recent evidence suggests that ferroptosis is a key pathogenic pathway involved in this dysfunction, affecting nerve cell death as well as diseases like Alzheimer's, Huntington's, and Parkinson's.

NEUROSCIENCE (2021)

Add to Collection

Article Endocrinology & Metabolism

Ferroptosis Enhanced Diabetic Renal Tubular Injury via HIF-1α/HO-1 Pathway in db/db Mice

Xiaomeng Feng et al.

Summary: The study found that ferroptosis aggravated diabetic nephropathy and damaged renal tubules in db/db mice through the HIF-1 alpha/HO-1 pathway.

FRONTIERS IN ENDOCRINOLOGY (2021)

Add to Collection

Article Biotechnology & Applied Microbiology

Downregulation of Circular RNA PSEN1 ameliorates ferroptosis of the high glucose treated retinal pigment epithelial cells via miR-200b-3p/cofilin-2 axis

Zhaoliang Zhu et al.

Summary: The study demonstrates that knockdown of circ-PSEN1 can alleviate HG-induced ferroptosis in ARPE19 cells via the miR-200b-3p/CFL2 axis, providing a novel therapeutic strategy for the treatment of DR.

BIOENGINEERED (2021)

Add to Collection

Article Pharmacology & Pharmacy

Ferroptosis is essential for diabetic cardiomyopathy and is prevented by sulforaphane via AMPK/NRF2 pathways

Xiang Wang et al.

Acta Pharmaceutica Sinica B (2021)

Add to Collection

Review Oncology

Mechanisms and pharmacological applications of ferroptosis: a narrative review

Jing-Jing Zhang et al.

Summary: Ferroptosis, a recently discovered form of cell death, is closely associated with the pathophysiological processes of various diseases such as tumors and nervous system diseases. Understanding the mechanisms involved in ferroptosis can inform new therapeutic targets and strategies for these diseases.

ANNALS OF TRANSLATIONAL MEDICINE (2021)

Add to Collection

Article Cell Biology

Inhibition of DNMT-1 alleviates ferroptosis through NCOA4 mediated ferritinophagy during diabetes myocardial ischemia/reperfusion injury

Wenyuan Li et al.

Summary: This study found that inhibition of DNMT-1 with 5-aza-CdR can reduce NCOA4-mediated ferritinophagy and myocardial injury during diabetes myocardial ischemia/reperfusion injury, leading to a decrease in ferroptosis levels.

CELL DEATH DISCOVERY (2021)

Add to Collection

Article Urology & Nephrology

The unique molecular mechanism of diabetic nephropathy: a bioinformatics analysis of over 250 microarray datasets

Le-Ting Zhou et al.

Summary: This study identified unique molecular mechanisms of diabetic nephropathy (DN) through analysis of genomic data, including differential gene expression in both glomerular and tubulointerstitial tissues. Enrichment analysis revealed the significant roles of these differentially expressed genes in relevant biological processes and pathways. Hub genes identified in the protein-protein interaction networks may play key roles in regulating the development of DN.

CLINICAL KIDNEY JOURNAL (2021)

Add to Collection

Article Medicine, Research & Experimental

Sp1-mediated upregulation of Prdx6 expression prevents podocyte injury in diabetic nephropathy via mitigation of oxidative stress and ferroptosis

Qianjin Zhang et al.

Summary: The study revealed that overexpression of Prdx6 can prevent podocyte injury induced by high glucose through modulation of oxidative stress and ferroptosis, providing new insights into the mechanism of diabetic nephropathy.

LIFE SCIENCES (2021)

Add to Collection

Article Oncology

Salusin-β participates in high glucose-induced HK-2 cell ferroptosis in a Nrf-2-dependent manner

Wen-Juan Wang et al.

Summary: The study revealed that salusin-beta plays a crucial role in diabetic kidney damage by regulating ferroptosis, with its activity exacerbating abnormal changes induced by high glucose. Furthermore, inactivation of the Nrf-2 signaling pathway by salusin-beta also influences the occurrence of ferroptosis.

MOLECULAR MEDICINE REPORTS (2021)

Add to Collection

Article Endocrinology & Metabolism

Iron aggravates hepatic insulin resistance in the absence of inflammation in a novel db/db mouse model with iron overload

Sandro Altamura et al.

Summary: The study reveals that hepatic iron accumulation may exacerbate symptoms related to metabolic syndrome and type 2 diabetes. It suggests that iron depletion strategies in combination with anti-diabetic drugs could potentially improve insulin resistance and diabetic late complications.

MOLECULAR METABOLISM (2021)

Add to Collection

Article Biochemistry & Molecular Biology

Inhibition of ferroptosis by up-regulating Nrf2 delayed the progression of diabetic nephropathy

Shuangwen Li et al.

Summary: Our research demonstrated the involvement of ferroptosis in the development of DN, and up-regulating Nrf2 with fenofibrate treatment inhibited diabetes-related ferroptosis, delaying the progression of DN. This study provided a new perspective on the development mechanism of DN and offered a new approach to delay the progression of DN.

FREE RADICAL BIOLOGY AND MEDICINE (2021)

Add to Collection

Article Biochemistry & Molecular Biology

The Effect of Abnormal Iron Metabolism on Osteoporosis

Jingmin Che et al.

BIOLOGICAL TRACE ELEMENT RESEARCH (2020)

Add to Collection

Review Urology & Nephrology

The multifaceted role of iron in renal health and disease

Rachel P. L. van Swelm et al.

NATURE REVIEWS NEPHROLOGY (2020)

Add to Collection

Review Endocrinology & Metabolism

Iron metabolism and type 2 diabetes mellitus: A meta-analysis and systematic review

Jingfang Liu et al.

JOURNAL OF DIABETES INVESTIGATION (2020)

Add to Collection

Article Cell Biology

Diabetes aggravates myocardial ischaemia reperfusion injury via activating Nox2-related programmed cell death in an AMPK-dependent manner

Chunyan Wang et al.

JOURNAL OF CELLULAR AND MOLECULAR MEDICINE (2020)

Add to Collection

Article Endocrinology & Metabolism

The Protective Effects of Cryptochlorogenic Acid on β-Cells Function in Diabetes in vivo and vitro via Inhibition of Ferroptosis

Yi Zhou

DIABETES METABOLIC SYNDROME AND OBESITY-TARGETS AND THERAPY (2020)

Add to Collection

Review Biochemistry & Molecular Biology

The Molecular Mechanisms of Iron Metabolism and Its Role in Cardiac Dysfunction and Cardioprotection

Tanya Ravingerova et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2020)

Add to Collection

Article Nutrition & Dietetics

Quercetin Alleviates Ferroptosis of Pancreatic beta Cells in Type 2 Diabetes

Dan Li et al.

NUTRIENTS (2020)

Add to Collection

Article Cell Biology

Paeoniflorin accelerates foot wound healing in diabetic rats though activating the Nrf2 pathway

Xiaolong Sun et al.

ACTA HISTOCHEMICA (2020)

Add to Collection

Article Pharmacology & Pharmacy

Ferroptosis involves in renal tubular cell death in diabetic nephropathy

Yue Wang et al.

EUROPEAN JOURNAL OF PHARMACOLOGY (2020)

Add to Collection

Article Cell Biology

Melatonin Suppresses Ferroptosis Induced by High Glucose via Activation of the Nrf2/HO-1 Signaling Pathway in Type 2 Diabetic Osteoporosis

Hongdong Ma et al.

OXIDATIVE MEDICINE AND CELLULAR LONGEVITY (2020)

Add to Collection

Article Biochemistry & Molecular Biology

The role of miRNAs as a predictor of multicentricity in breast cancer

Huseyin Akbulut et al.

MOLECULAR BIOLOGY REPORTS (2019)

Add to Collection

Review Endocrinology & Metabolism

Evidence and potential mechanisms of traditional Chinese medicine for the treatment of type 2 diabetes: A systematic review and meta-analysis

Jiaxing Tian et al.

DIABETES OBESITY & METABOLISM (2019)

Add to Collection

Article Genetics & Heredity

RNA-Seq Revealed Novel Non-proliferative Retinopathy Specific Circulating MiRNAs in T2DM Patients

Zimeng Li et al.

FRONTIERS IN GENETICS (2019)

Add to Collection

Review Pharmacology & Pharmacy

Enlightening the role of high mobility group box 1 (HMGB1) in inflammation: Updates on receptor signalling

Yam Nath Paudel et al.

EUROPEAN JOURNAL OF PHARMACOLOGY (2019)

Add to Collection

Article Pharmacology & Pharmacy

Paeoniflorin protects against intestinal ischemia/reperfusion by activating LKB1/AMPK and promoting autophagy

Jin Wen et al.

PHARMACOLOGICAL RESEARCH (2019)

Add to Collection

Article Cell Biology

Downregulation of P2Y12 in the superior cervical ganglia alleviates abnormal sympathetic activity after myocardial ischemia

Lifang Zou et al.

JOURNAL OF CELLULAR PHYSIOLOGY (2018)

Add to Collection

Article Biochemistry & Molecular Biology

Sennoside A protects mitochondrial structure and function to improve high-fat diet-induced hepatic steatosis by targeting VDAC1

Jiamei Le et al.

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2018)

Add to Collection

Review Biochemistry & Molecular Biology

Molecular mechanisms of cell death: recommendations of the Nomenclature Committee on Cell Death 2018

Lorenzo Galluzzi et al.

CELL DEATH AND DIFFERENTIATION (2018)

Add to Collection

Article Biotechnology & Applied Microbiology

Antidiabetic and Antiobesity Effects of Artemether in db/db Mice

Yu Guo et al.

BIOMED RESEARCH INTERNATIONAL (2018)

Add to Collection

Review Pharmacology & Pharmacy

The Pathogenesis of Diabetes Mellitus by Oxidative Stress and Inflammation: Its Inhibition by Berberine

Xueling Ma et al.

FRONTIERS IN PHARMACOLOGY (2018)

Add to Collection

Article Biochemistry & Molecular Biology

ACSL4 dictates ferroptosis sensitivity by shaping cellular lipid composition

Sebastian Doll et al.

NATURE CHEMICAL BIOLOGY (2017)

Add to Collection

Review Medicine, General & Internal

Diabetic Foot Ulcers and Their Recurrence

David G. Armstrong et al.

NEW ENGLAND JOURNAL OF MEDICINE (2017)

Add to Collection

Correction Multidisciplinary Sciences

Puerarin attenuates diabetic kidney injury through the suppression of NOX4 expression in podocytes (vol 7, 2017)

Xueling Li et al.

SCIENTIFIC REPORTS (2017)

Add to Collection

Article Multidisciplinary Sciences

Mulberry leaf alleviates streptozotocin-induced diabetic rats by attenuating NEFA signaling and modulating intestinal microflora

Yao Sheng et al.

SCIENTIFIC REPORTS (2017)

Add to Collection

Article Integrative & Complementary Medicine

Impact of mulberry leaf extract on type 2 diabetes (Mul-DM): A randomized, placebo-controlled pilot study

Daniel M. Riche et al.

COMPLEMENTARY THERAPIES IN MEDICINE (2017)

Add to Collection

Article Chemistry, Multidisciplinary

Artemisinin-A Gift from Traditional Chinese Medicine to the World (Nobel Lecture)

Youyou Tu

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2016)

Add to Collection

Review Biochemistry & Molecular Biology

Mechanisms of ferroptosis

Jennifer Yinuo Cao et al.

CELLULAR AND MOLECULAR LIFE SCIENCES (2016)

Add to Collection

Article Immunology

Protective effect of platycodin D on liver injury in alloxan-induced diabetic mice via regulation of Treg/Th-17 balance

Tong Chen et al.

INTERNATIONAL IMMUNOPHARMACOLOGY (2015)

Add to Collection

Review Endocrinology & Metabolism

Harnessing the immunological properties of stem cells as a therapeutic option for diabetic nephropathy

Francesca D'Addio et al.

ACTA DIABETOLOGICA (2014)

Add to Collection

Review Chemistry, Medicinal

Phytochemistry and biological properties of glabridin

Charlotte Simmler et al.

FITOTERAPIA (2013)

Add to Collection

Article Oncology

Hypoglycemic effects of glabridin, a polyphenolic flavonoid from licorice, in an animal model of diabetes mellitus

Feihua Wu et al.

MOLECULAR MEDICINE REPORTS (2013)

Add to Collection

Review Food Science & Technology

Curcumin-free turmeric exhibits anti-inflammatory and anticancer activities: Identification of novel components of turmeric

Bharat B. Aggarwal et al.

MOLECULAR NUTRITION & FOOD RESEARCH (2013)

Add to Collection

Article Biochemistry & Molecular Biology

Ferroptosis: An Iron-Dependent Form of Nonapoptotic Cell Death

Scott J. Dixon et al.

CELL (2012)

Add to Collection

Article Endocrinology & Metabolism

Enhanced Nrf2 Activity Worsens Insulin Resistance, Impairs Lipid Accumulation in Adipose Tissue, and Increases Hepatic Steatosis in Leptin-Deficient Mice

Jialin Xu et al.

DIABETES (2012)

Add to Collection

Article Endocrinology & Metabolism

Radix Astragali lowers kidney oxidative stress in diabetic rats treated with insulin

Y. Gao et al.

ENDOCRINE (2012)

Add to Collection

Article Hematology

Mitochondrial ferritin: A new player in iron metabolism

J Drysdale et al.

BLOOD CELLS MOLECULES AND DISEASES (2002)

Add to Collection

© Peeref 2019-2024. All rights reserved.