☆ 4.4 Article

GDP dissociation inhibitor 1 (GDI1) attenuates β-amyloid-induced neurotoxicity in Alzheimer's diseases

NEUROSCIENCE LETTERS (2024)

Related references

Note: Only part of the references are listed.

Article Neurosciences

Evaluations of the neuroprotective effects of a dual-target isoquinoline inhibitor in the triple transgenic mouse model of Alzheimer?s disease

Rong Wei et al.

Summary: Alzheimer's disease (AD) patients exhibit neuropathological features, such as amyloid-beta (A beta) plaques and neurogenic fibrillary tangles. These features are thought to play important pathogenic roles in neuronal dysfunction and apoptosis in the disease progression. A dual-target isoquinoline inhibitor (9S) showed neuroprotective effects through modulations of GSK-3 beta phosphorylation and reactive oxygen species, leading to significant improvement in cognitive deficits in early-stage AD models.

NEUROSCIENCE LETTERS (2023)

Add to Collection

Article Neurosciences

BMP9 ameliorates amyloid pathology by promoting low-density lipoprotein receptor-related protein 1 expression in APP/PS1 transgenic mice

Lu Xiong et al.

Summary: Our previous study showed that bone morphogenetic protein 9 (BMP9) can improve amyloid pathology and cognitive impairments in APP/PS1 mice. This study found that BMP9 significantly increased the expression of low-density lipoprotein receptor-related protein 1 (LRP1) in the brains of APP/PS1 mice. Silencing LRP1 promoted amyloid plaque accumulation and neuroinflammation, and impaired learning and memory functions in BMP9-treated APP/PS1 mice.

NEUROSCIENCE LETTERS (2023)

Add to Collection

Article Neurosciences

TNIP2 inhibits amyloidogenesis by regulating the 3′UTR of BACE1: An in vitro study

Long Chen et al.

Summary: TNIP2 plays a crucial role in amyloidogenesis associated with Alzheimer's disease (AD). This study reveals that TNIP2 protein level is significantly decreased in AD models. Overexpression of TNIP2 reduces the protein levels of BACE1 and C99, as well as Aβ peptides, and inhibits amyloidogenesis. TNIP2 promotes the degradation of BACE1 mRNA by binding to its 3' UTR, leading to the inhibition of amyloidogenic processing.

NEUROSCIENCE LETTERS (2023)

Add to Collection

Article Geriatrics & Gerontology

lncRNA-associated ceRNA network revealing the potential regulatory roles of ferroptosis and immune infiltration in Alzheimer's disease

Yejun Tan et al.

Summary: This study identified five ferroptosis-related genes highly associated with Alzheimer's disease (AD) and constructed a competing endogenous RNA (ceRNA) network to explore the regulatory mechanism. The study also revealed the immune cell infiltration landscape in AD and its correlation with the identified genes.

FRONTIERS IN AGING NEUROSCIENCE (2023)

Add to Collection

Review Neurosciences

Alzheimer's disease: The role of proteins in formation, mechanisms, and new therapeutic approaches

Amirreza Gholami

Summary: Alzheimer's disease is a progressive neurological disorder that affects the central nervous system, leading to memory and cognitive decline. The disease is characterized by structural changes in the brain, including neuron loss, neurofibrillary tangles, and the formation of amyloid beta plaques. Genetic and environmental factors play a role in the development of the disease. Promising therapeutic strategies include drug therapies, immunotherapy, and brain stimulation techniques.

NEUROSCIENCE LETTERS (2023)

Add to Collection

Article Clinical Neurology

Mesial temporal tau in amyloid-β-negative cognitively normal older persons

Natasha Krishnadas et al.

Summary: In Aβ- cognitively unimpaired individuals, tau tracer binding in the mesial temporal lobe is age-related and associated with smaller hippocampal volume, but not with subjective or objective cognitive impairment.

ALZHEIMERS RESEARCH & THERAPY (2022)

Add to Collection

Review Biochemistry & Molecular Biology

New Insights into lncRNAs in Aβ Cascade Hypothesis of Alzheimer's Disease

Yitong Hao et al.

Summary: This article discusses the unique regulatory functions of lncRNAs in Alzheimer's disease, focusing on their interaction with critical molecules and their potential applications in diagnosis and treatment.

BIOMOLECULES (2022)

Add to Collection

Article Biochemistry & Molecular Biology

Targeting MicroRNA-485-3p Blocks Alzheimer's Disease Progression

Han Seok Koh et al.

Summary: Treatment with miR-485-3p ASO reduces A beta plaque accumulation, tau pathology development, neuroinflammation, and cognitive decline in an AD transgenic mouse model by enhancing A beta clearance and reducing apoptosis. Additionally, miR-485-3p ASO administration decreases proinflammatory cytokine secretion, ultimately alleviating cognitive impairment.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2021)

Add to Collection

Article Geriatrics & Gerontology

Deregulated lncRNA MAGI2-AS3 in Alzheimer's disease attenuates amyloid-β induced neurotoxicity and neuroinflammation by sponging miR-374b-5p

Jingjing Zhang et al.

Summary: This study explored the regulatory effects of MAGI2-AS3 and miR-374b-5p on A beta-induced neurotoxicity and neuroinflammation in Alzheimer's disease. The findings suggest that the MAGI2-AS3/miR-374b-5p axis may serve as potential biomarkers and therapeutic targets for AD, as it can attenuate neuronal injury and inflammation. The expression levels of MAGI2-AS3 and miR-374b-5p were negatively correlated in AD patients and correlated with disease severity, highlighting their potential importance in AD pathogenesis.

EXPERIMENTAL GERONTOLOGY (2021)

Add to Collection

Review Physiology

Lactate as an Astroglial Signal Augmenting Aerobic Glycolysis and Lipid Metabolism

Anemari Horvat et al.

Summary: Astrocytes play a key role in metabolic homeostasis in the brain by producing and releasing L-lactate for neurons, as well as potentially serving as a signaling molecule. The mechanisms of L-lactate signaling, particularly through G-protein coupled receptors, are still being investigated, with a focus on how L-lactate influences cAMP production in astrocytes and metabolic excitability. This dynamic process highlights the intricate relationship between astrocytes and neurons in maintaining brain function.

FRONTIERS IN PHYSIOLOGY (2021)

Add to Collection

Article Geriatrics & Gerontology

The Relationship Between Lower Urinary Tract Symptoms and Severity of Alzheimer's Disease

Che-Wei Chang et al.

Summary: Urge urinary incontinence (UI) is more prevalent in elderly patients with dementia, especially Alzheimer's disease (AD). This study found a higher lower urinary tract symptom score and a significant correlation between CDR-SB score and urge UI in AD patients.

AMERICAN JOURNAL OF ALZHEIMERS DISEASE AND OTHER DEMENTIAS (2021)

Add to Collection

Article Biotechnology & Applied Microbiology

Overexpression of GDP dissociation inhibitor 1 gene associates with the invasiveness and poor outcomes of colorectal cancer

Xiao Xie et al.

Summary: The study evaluated the prognostic and predictive value of GDI1 in colorectal cancer, indicating that high levels of GDI1 are significantly associated with worse survival rates and can serve as a prognostic biomarker for CRC patients.

BIOENGINEERED (2021)

Add to Collection

Article Biochemistry & Molecular Biology

Plasma P-tau181 in Alzheimer's disease: relationship to other biomarkers, differential diagnosis, neuropathology and longitudinal progression to Alzheimer's dementia

Shorena Janelidze et al.

NATURE MEDICINE (2020)

Add to Collection

Review Neurosciences

Recent Advancements in Pathogenesis, Diagnostics and Treatment of Alzheimer's Disease

Sahil Khan et al.

CURRENT NEUROPHARMACOLOGY (2020)

Add to Collection

Article Oncology

Integrated analysis of miRNA and mRNA expression in the blood of patients with Alzheimer's disease

Zongwen Wang et al.

MOLECULAR MEDICINE REPORTS (2020)

Add to Collection

Article Neurosciences

A Novel Connectome-based Electrophysiological Study of Subjective Cognitive Decline Related to Alzheimer's Disease by Using Resting-state High-density EEG EGI GES 300

Lazarou Ioulietta et al.

BRAIN SCIENCES (2020)

Add to Collection

Article Medicine, General & Internal

BDNF-producing, amyloid β-specific CD4 T cells as targeted drug-delivery vehicles in Alzheimer's disease

Ekaterina Eremenko et al.

EBIOMEDICINE (2019)

Add to Collection

Article Neurosciences

Differential effect of amyloid beta peptides on mitochondrial axonal trafficking depends on their state of aggregation and binding to the plasma membrane

Liang Zhang et al.

NEUROBIOLOGY OF DISEASE (2018)

Add to Collection

Article Biochemistry & Molecular Biology

Exome sequencing identifies a novel mutation of the GDI1 gene in a Chinese non-syndromic X-linked intellectual disability family

Yongheng Duan et al.

GENETICS AND MOLECULAR BIOLOGY (2017)

Add to Collection

Review Neurosciences

Alzheimer's Disease: From Genetic Variants to the Distinct Pathological Mechanisms

Qiying Sun et al.

FRONTIERS IN MOLECULAR NEUROSCIENCE (2017)

Add to Collection

Article Clinical Neurology

Inhibition of beta-amyloid-induced neurotoxicity by pinocembrin through Nrf2/HO-1 pathway in SH-SY5Y cells

Yumin Wang et al.

JOURNAL OF THE NEUROLOGICAL SCIENCES (2016)

Add to Collection

Article Biochemistry & Molecular Biology

Temporal lobe proteins implicated in synaptic failure exhibit differential expression and deamidation in vascular dementia

Xavier Gallart-Palau et al.

NEUROCHEMISTRY INTERNATIONAL (2015)

Add to Collection

Article Neurosciences

Inactivation of the Paraoxonase 1 Gene Affects the Expression of Mouse Brain Proteins Involved in Neurodegeneration

Joanna Suszynska-Zajczyk et al.

JOURNAL OF ALZHEIMERS DISEASE (2014)

Add to Collection

Article Toxicology

Effect of fetal exposure to bisphenol A on brain mediated by X-chromosome inactivation

Takayuki Kumamoto et al.

JOURNAL OF TOXICOLOGICAL SCIENCES (2013)

Add to Collection

Article Biochemistry & Molecular Biology

NCBI GEO: archive for functional genomics data sets-update

Tanya Barrett et al.

NUCLEIC ACIDS RESEARCH (2013)

Add to Collection

Article Multidisciplinary Sciences

Forebrain Deletion of αGDI in Adult Mice Worsens the Pre-Synaptic Deficit at Cortico-Lateral Amygdala Synaptic Connections

Veronica Bianchi et al.

PLOS ONE (2012)

Add to Collection

Article Biochemistry & Molecular Biology

Cognitive impairment in Gdi1-deficient mice is associated with altered synaptic vesicle pools and short-term synaptic plasticity, and can be corrected by appropriate learning training

Veronica Bianchi et al.

HUMAN MOLECULAR GENETICS (2009)

Add to Collection

Article Neurosciences

A truncated tropo-myosine-related kinase B receptor, T1, regulates glial cell morphology via rho GDP dissociation inhibitor 1

K Ohira et al.

JOURNAL OF NEUROSCIENCE (2005)

Add to Collection

Article Biochemistry & Molecular Biology

Deletion of the mental retardation gene Gdi1 impairs associative memory and alters social behavior in mice

P D'Adamo et al.

HUMAN MOLECULAR GENETICS (2002)

Add to Collection

© Peeref 2019-2024. All rights reserved.