Journal
CARDIOVASCULAR PATHOLOGY
Volume 68, Issue -, Pages -Publisher
ELSEVIER SCIENCE INC
DOI: 10.1016/j.carpath.2023.107588
Keywords
Cusps; Leaflets; Vegetations; Papillary fibroelastoma; Cardiac anatomy; Age-related
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This study examined the prevalence and characteristics of Lambl excrescences (LEs) in 403 healthy human hearts and found that the prevalence of LEs in healthy hearts is far lower than previously reported.
Lambl excrescences (LEs) were initially described in the mid-1800s during autopsies of human hearts, and their significance and biology have been debated ever since. LEs are typically found on aortic and pulmonary valve (semilunar) cusps. There is debate concerning whether LEs are a significant cause of thromboembolic events, or whether they are harmless growths. However, there have not been many reports discussing LEs, and fewer still have examined the prevalence and characteristics of LEs in healthy human hearts. Those who have examined LE prevalence have reported a very high incidence of LEs (85- 90%). Herein, we examine LE prevalence and characteristics (size, location, number) in 403 healthy human hearts across all age groups. We find that the prevalence of LEs in healthy hearts is far lower than previously reported.
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