4.7 Article

The pathogenic and clinical characteristics of severe fever with thrombocytopenia syndrome patients with co-infections

Journal

Publisher

FRONTIERS MEDIA SA
DOI: 10.3389/fcimb.2023.1298050

Keywords

SFTS; co-infection; mortality; Aspergillus fumigatus; bacterial infection

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This study retrospectively analyzed the pathogenic and clinical characteristics of severe fever with thrombocytopenia syndrome (SFTS) patients with co-infections. The findings revealed a higher mortality rate among SFTS patients with co-infection compared to those without co-infection. The pathogens responsible for co-infection were primarily isolated from respiratory specimens, with fungal and bacterial infections being the most common. SFTS patients with co-infection displayed significant alterations in inflammatory markers, coagulation function, and liver function indicators compared to non-co-infection patients.
Objective The study aimed to comprehensively describe and evaluate the pathogenic and clinical characteristics of severe fever with thrombocytopenia syndrome (SFTS) patients with co-infections.Methods We retrospectively collected clinical data and laboratory indicators of the SFTS patients at Tongji Hospital from October 2021 to July 2023.Results A total of 157 patients with SFTS virus (SFTSV) infection were involved in the analysis, including 43 co-infection and 114 non-co-infection patients. The pathogens responsible for co-infection were primarily isolated from respiratory specimens. Fungal infections, primarily Aspergillus fumigatus, were observed in 22 cases. Bacterial infections, with Klebsiella pneumoniae and carbapenem-resistant Acinetobacter baumannii as the main pathogens, were identified in 20 cases. SFTS patients with co-infection exhibited higher mortality (P=0.011) compared to non-co-infection patients. Among SFTS patients co-infected with both bacteria and fungi (8 cases) or specific drug-resistant strains (11 cases), the mortality rate was as high as 70% (14/19). In comparison with the non-co-infection group, SFTS patients with co-infection displayed significant alteration in inflammatory markers, coagulation function, and liver function indicators.Conclusion The mortality rate of SFTS patients with co-infection is relatively high, underscoring the need for enhanced monitoring and timely, appropriate treatment to minimize the mortality rate.

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