From inflammation to metastasis: The central role of miR-155 in modulating NF-κB in cancer

Cancer is a multifaceted, complex disease characterized by unchecked cell growth, genetic mutations, and dysregulated signalling pathways. These factors eventually cause evasion of apoptosis, sustained angiogenesis, tissue invasion, and metastasis, which makes it difficult for targeted therapeutic interventions to be effective. MicroRNAs (miRNAs) are essential gene expression regulators linked to several biological processes, including cancer and inflammation. The NF-kappa B signalling pathway, a critical regulator of inflammatory reactions and oncogenesis, has identified miR-155 as a significant participant in its modulation. An intricate network of transcription factors known as the NF-kappa B pathway regulates the expression of genes related to inflammation, cell survival, and immunological responses. The NF-kappa B pathway's dysregulation contributes to many cancer types' development, progression, and therapeutic resistance. In numerous cancer models, the well-studied miRNA miR155 has been identified as a crucial regulator of NF-kappa B signalling. The p65 subunit and regulatory molecules like I kappa B are among the primary targets that miR-155 directly targets to alter NF-kappa B activity. The molecular processes by which miR-155 affects the NF-kappa B pathway are discussed in this paper. It also emphasizes the miR-155's direct and indirect interactions with important NF-kappa B cascade elements to control the expression of NF-kappa B subunits. We also investigate how miR-155 affects NF-kappa B downstream effectors in cancer, including inflammatory cytokines and anti-apoptotic proteins.

Automated summary

Cancer is a complex disease caused by multiple factors, and miR-155 plays a significant role as a regulator of the NF-kappa B signaling pathway, contributing to cancer development and progression.