4.4 Article

Injectable phase-separated tetra-armed poly(ethylene glycol) hydrogel scaffold allows sustained release of growth factors to enhance the repair of critical bone defects

Related references

Note: Only part of the references are listed.
Review Biotechnology & Applied Microbiology

Drug delivery systems based on polyethylene glycol hydrogels for enhanced bone regeneration

Shouye Sun et al.

Summary: This paper reviews the application of polyethylene glycol (PEG)-based hydrogels in the treatment of bone defects. The advantages and disadvantages of PEG as a carrier are analyzed, and various modification methods of PEG hydrogels are summarized. On this basis, the application of PEG-based hydrogel drug delivery systems in promoting bone regeneration in recent years is summarized. Finally, the shortcomings and future developments of PEG-based hydrogel drug delivery systems are discussed. This review provides a theoretical basis and fabrication strategy for the application of PEG-based composite drug delivery systems in local bone defects.

FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY (2023)

Article Geriatrics & Gerontology

Global, regional, and national burden of bone fractures in 204 countries and territories, 1990-2019: a systematic analysis from the Global Burden of Disease Study 2019

Ai-Min Wu et al.

Summary: The global incidence, prevalence, and years lived with disability (YLDs) of fractures showed a slight decrease from 1990 to 2019, but the absolute counts increased substantially. Older individuals have a particularly high risk of fractures, highlighting the importance of injury prevention efforts and osteoporosis screening and treatment for reducing the overall burden.

LANCET HEALTHY LONGEVITY (2021)

Article Multidisciplinary Sciences

Heparin-mediated delivery of bone morphogenetic protein-2 improves spatial localization of bone regeneration

Marian H. Hettiaratchi et al.

SCIENCE ADVANCES (2020)

Review Engineering, Biomedical

Specialty Tough Hydrogels and Their Biomedical Applications

Stephanie Fuchs et al.

ADVANCED HEALTHCARE MATERIALS (2020)

Article Materials Science, Multidisciplinary

Tuning protein delivery from different architectures of layer-by-layer assemblies on polymer films

Giovanne Delechiave et al.

MATERIALS ADVANCES (2020)

Article Dentistry, Oral Surgery & Medicine

Release kinetics of the model protein FITC-BSA from different polymer-coated bovine bone substitutes

Julian Lommen et al.

HEAD & FACE MEDICINE (2019)

Article Nanoscience & Nanotechnology

Sustained and Prolonged Delivery of Protein Therapeutics from Two-Dimensional Nanosilicates

Lauren M. Cross et al.

ACS APPLIED MATERIALS & INTERFACES (2019)

Review Chemistry, Multidisciplinary

Formulation, Delivery and Stability of Bone Morphogenetic Proteins for Effective Bone Regeneration

Inas El Bialy et al.

PHARMACEUTICAL RESEARCH (2017)

Article Cell & Tissue Engineering

A Versatile Protocol for Studying Calvarial Bone Defect Healing in a Mouse Model

Rebekah M. Samsonraj et al.

TISSUE ENGINEERING PART C-METHODS (2017)

Article Engineering, Biomedical

Fast-forming hydrogel with ultralow polymeric content as an artificial vitreous body

Kaori Hayashi et al.

NATURE BIOMEDICAL ENGINEERING (2017)

Article Biochemistry & Molecular Biology

Hydrogels for Therapeutic Delivery: Current Developments and Future Directions

Sytze J. Buwalda et al.

BIOMACROMOLECULES (2017)

Article Biotechnology & Applied Microbiology

Sustained release of rhBMP-2 from microporous tricalciumphosphate using hydrogels as a carrier

Steffen Kissling et al.

BMC BIOTECHNOLOGY (2016)

Review Nanoscience & Nanotechnology

Designing hydrogels for controlled drug delivery

Jianyu Li et al.

NATURE REVIEWS MATERIALS (2016)

Review Pharmacology & Pharmacy

Biomaterial strategies for engineering implants for enhanced osseointegration and bone repair

Rachit Agarwal et al.

ADVANCED DRUG DELIVERY REVIEWS (2015)

Article Geriatrics & Gerontology

Effects of low dose FGF-2 and BMP-2 on healing of calvarial defects in old mice

Lyndon F. Charles et al.

EXPERIMENTAL GERONTOLOGY (2015)

Review Biochemistry & Molecular Biology

Osteoblast and osteocyte: Games without frontiers

Mattia Capulli et al.

ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS (2014)

Review Biochemistry & Molecular Biology

An Overview of Poly(lactic-co-glycolic) Acid (PLGA)-Based Biomaterials for Bone Tissue Engineering

Piergiorgio Gentile et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2014)

Article Cell & Tissue Engineering

Controlled release of BMP-2 from a sintered polymer scaffold enhances bone repair in a mouse calvarial defect model

Cheryl V. Rahman et al.

JOURNAL OF TISSUE ENGINEERING AND REGENERATIVE MEDICINE (2014)

Article Engineering, Biomedical

Bone healing by sterilizable calcium phosphate tetrapods eluting osteogenic molecules

Yujiro Maeda et al.

BIOMATERIALS (2013)

Article Polymer Science

Mechanical properties of a polymer network of Tetra-PEG gel

Asumi Sugimura et al.

POLYMER JOURNAL (2013)

Review Multidisciplinary Sciences

Growth factor delivery-based tissue engineering: general approaches and a review of recent developments

Kangwon Lee et al.

JOURNAL OF THE ROYAL SOCIETY INTERFACE (2011)

Article Cell & Tissue Engineering

OSTEOGENIC DIFFERENTIATION AS A RESULT OF BMP-2 PLASMID DNA BASED GENE THERAPY IN VITRO AND IN VIVO

F. Wegman et al.

EUROPEAN CELLS & MATERIALS (2011)

Review Endocrinology & Metabolism

Guidelines for Assessment of Bone Microstructure in Rodents Using Micro-Computed Tomography

Mary L. Bouxsein et al.

JOURNAL OF BONE AND MINERAL RESEARCH (2010)

Article Cell & Tissue Engineering

Collagen-hydroxyapatite composites for hard tissue repair

D. A. Wahl et al.

EUROPEAN CELLS & MATERIALS (2006)

Article Chemistry, Multidisciplinary

Interpretation of protein adsorption: Surface-induced conformational changes

P Roach et al.

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2005)

Review Biotechnology & Applied Microbiology

Delivering on the promise of bone morphogenetic proteins

RH Li et al.

TRENDS IN BIOTECHNOLOGY (2001)