Ciprofol is primarily glucuronidated by UGT1A9 and predicted not to cause drug-drug interactions with typical substrates of CYP1A2, CYP2B6, and CYP2C19

Review Biotechnology & Applied Microbiology

Ciprofol: A Novel Alternative to Propofol in Clinical Intravenous Anesthesia?

Ming Lu et al.

Summary: Ciprofol, a novel compound developed in China, has been approved for sedation and anesthesia purposes. It has shown high efficacy, good selectivity, and minimal adverse reactions in clinical studies, indicating promising clinical application potential.

BIOMED RESEARCH INTERNATIONAL (2023)

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Article Medicine, General & Internal

Safety, pharmacokinetics and pharmacodynamics of a novel γ-aminobutyric acid (GABA) receptor potentiator, HSK3486, in Chinese patients with hepatic impairment

Yue Hu et al.

Summary: The study found that hepatic impairment may affect the exposure of HSK3486, but has little impact on its pharmacodynamics. In subjects with mild or moderate hepatic impairment, HSK3486 was well tolerated and dose adjustment was not necessary.

ANNALS OF MEDICINE (2022)

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Article Pharmacology & Pharmacy

Mass balance, pharmacokinetics and pharmacodynamics of intravenous HSK3486, a novel anaesthetic, administered to healthy subjects

Yicong Bian et al.

Summary: This study investigated the pharmacokinetics of the novel anesthetic HSK3486 in healthy subjects, demonstrating its rapid onset of action and favorable safety profile.

BRITISH JOURNAL OF CLINICAL PHARMACOLOGY (2021)

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Review Health Care Sciences & Services

The Functionality of UDP-Glucuronosyltransferase Genetic Variants and their Association with Drug Responses and Human Diseases

Yazun Jarrar et al.

Summary: UDP-glucuronosyltransferases (UGTs) are enzymes involved in metabolizing fatty acids and prescription drugs, with highly polymorphic genes that can impact drug pharmacokinetics and disease susceptibility. Understanding the functional information of genetic variants in UGT genes is essential for comprehending individual differences in drug responses and toxicity susceptibility.

JOURNAL OF PERSONALIZED MEDICINE (2021)

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Article Pharmacology & Pharmacy