Engineering cyanine cyclizations for new fluorogenic probes

As the need for specific fluorescent probes that enable high sensitivity and super-resolution imaging experiments continues to grow, it is imperative to develop new, well-characterized methods to modulate the emission of fluorophores. Now, a general platform affords visible-to-NIR fluorogenic fluorophores by engineering a simple cyclization event into cyanine dyes.

Automated summary

A general platform has been developed to create visible-to-NIR fluorogenic fluorophores by introducing a simple cyclization event into cyanine dyes, addressing the growing demand for specific fluorescent probes in high sensitivity and super-resolution imaging experiments.