4.7 Article

NIR-II responsive Janus nanoparticles amplify immunogenic cell death for enhanced cancer immunotherapy

Related references

Note: Only part of the references are listed.
Article Chemistry, Multidisciplinary

Melanin-Based Immunoregulatory Nanohybrids Enhance Antitumor Immune Responses in Breast Cancer Mouse Model

Kangli Guo et al.

Summary: This study designed biodegradable melanin/MnO x nanohybrids to target the tumor microenvironment (TME) and enhance immunomodulation for cancer therapy. Under NIR light irradiation, the nanohybrids trigger immunogenic cell death and release of tumor-associated antigens, while inducing dendritic cell maturation to initiate immune responses. The nanohybrids also possess immunoregulatory properties to reshape the immunosuppressive TME and downregulate PD-L1. In vivo experiments showed significantly enhanced antitumor and antimetastatic effects, confirming the efficacy of melanin/MnO x nanohybrids for immunomodulation-enhanced cancer therapy.

ACS NANO (2023)

Article Chemistry, Multidisciplinary

Rod-Shaped Polymeric Nanoparticles Intervene Neutrophils for Efficient Ischemic Stroke Therapy

Zhuolun Song et al.

Summary: In this study, rod-shaped polylactic acid polyglycolic acid nanoparticles encapsulated with piceatannol were developed to target and interfere with the interaction between neutrophils and inflamed endothelial cells in ischemic stroke. The nanoparticles with an aspect ratio of 5 exhibited enhanced internalization by neutrophils and were able to block neutrophil adherence to endothelial cells and inhibit infiltration into the blood-brain barrier. The released piceatannol within the ischemic region also inhibited neuroinflammation.

ADVANCED FUNCTIONAL MATERIALS (2023)

Article Chemistry, Multidisciplinary

Biodegradable NIR-II Pseudo Conjugate Polymeric Nanoparticles Amplify Photodynamic Immunotherapy via Alleviation of Tumor Hypoxia and Tumor-Associated Macrophage Reprogramming

Jia Wan et al.

Summary: Photodynamic therapy has been successful in cancer treatment, but hypoxia in solid tumors can limit its efficacy. In this study, a novel photodynamic polymer based on PSP nanoparticles is designed to deliver a vascular normalization agent, resulting in improved tumor oxygenation and enhanced immune responses.

ADVANCED MATERIALS (2023)

Article Chemistry, Multidisciplinary

Pyroptosis-Mediated Synergistic Photodynamic and Photothermal Immunotherapy Enabled by a Tumor-Membrane-Targeted Photosensitive Dimer

Yuqi Tang et al.

Summary: Overcoming resistance to apoptosis and immunosuppression in tumor cells is a challenge in improving cancer immunotherapy. By combining photodynamic therapy and photothermal therapy, a tumor cell membrane-targeted aggregation-induced emission photosensitive dimer can induce efficient immunogenic cell death, enhancing the effectiveness of cancer immunotherapy.

ADVANCED MATERIALS (2023)

Article Pharmacology & Pharmacy

Nanotechnology-enabled immunogenic cell death for improved cancer immunotherapy

Wenpan Li et al.

Summary: Tumor immunotherapy, specifically tumor immunogenic cell death (ICD), has shown great potential for cancer therapy. Nanoparticles, such as liposomes, nanostructured lipid carriers, and inorganic nanoparticles, have been widely studied as vehicles for delivering ICD inducers. This review summarizes the strategies of different nanoparticles for ICD-induced cancer immunotherapy and discusses their advantages, disadvantages, and potential solutions. It aims to provide insights into the design of effective nanoparticulate systems for the therapeutic delivery of ICD inducers, ultimately promoting the development of ICD-mediated cancer immunotherapy.

INTERNATIONAL JOURNAL OF PHARMACEUTICS (2023)

Article Chemistry, Multidisciplinary

Polyphotosensitizer-Based Nanoparticles with Michael Addition Acceptors Inhibiting GST Activity and Cisplatin Deactivation for Enhanced Chemotherapy and Photodynamic Immunotherapy

Qinxin Zhao et al.

Summary: A reactive oxygen species (ROS)-responsive polyphotosensitizer-based nanoparticle (NP2) is designed to inhibit GST activity and cisplatin deactivation, as well as stimulate antitumor immune response, thus providing a new paradigm for the multimodal treatment of tumors.

ADVANCED SCIENCE (2023)

Article Nanoscience & Nanotechnology

Bioengineered Bacterial Membrane Vesicles with Multifunctional Nanoparticles as a Versatile Platform for Cancer Immunotherapy

Xin Zheng Liu et al.

Summary: In this study, a drug-free bacteria-derived outer membrane vesicle (OMV) functionalized Fe3O4-MnO2 (FMO) nanoplatform was developed for neutrophil-mediated targeted delivery and photothermally enhanced cancer immunotherapy. The modified OMVs enhanced the accumulation of FMO NPs at the tumor site and induced immunogenic cell death (ICD) and regulated the tumor hypoxia environment. Additionally, OMVs effectively activated immune cells and the photothermal therapy (PTT) caused by MnO2 and Fe3O4 stimulated systemic immunity and promoted the enrichment of neutrophil-equipped nanoparticles. This multi-modal treatment system with targeted delivery capability achieved effective tumor immunotherapy and prevention of tumor recurrence.

ACS APPLIED MATERIALS & INTERFACES (2023)

Article Chemistry, Multidisciplinary

A Forward Vision for Chemodynamic Therapy: Issues and Opportunities

Peiran Zhao et al.

Summary: Since the fusion of Fenton chemistry and nanomedicine into cancer therapy, significant progress has been made in the field of chemodynamic therapy (CDT). However, the exact mechanism of CDT is obscured by the unique tumor chemical environment and inevitable nanoparticle-cell interactions, hindering further development. This Scientific Perspective clarifies the significance of CDT, deconstructs the complex mechanism into primitive chemical and biological interactions, and discusses in detail the research directions based on chemical kinetics and biological signaling pathways. Moreover, beneficial outlooks are presented to advance the evolution of next-generation CDT. Hopefully, this Scientific Perspective can inspire new ideas and advances for CDT and provide a reference for breaking down interdisciplinary barriers in the field of nanomedicine.

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2023)

Article Chemistry, Multidisciplinary

Orchestrated Yolk-Shell Nanohybrids Regulate Macrophage Polarization and Dendritic Cell Maturation for Oncotherapy with Augmented Antitumor Immunity

Xiaoyi Zhao et al.

Summary: This study explores the intrinsic immunomodulatory effects of orchestrated nanoparticles to trigger tumor antigen release and reverse immunosuppression in order to achieve potent antitumor immunity and enhanced cancer therapy. The construction of yolk-shell nanohybrids with tailored properties establishes a novel strategy for multifunctional nanoplatforms for effective cancer therapy with immunomodulation-enhanced antitumor immunity. Potent antitumor effects were found to substantially inhibit the growth of both primary and distant tumors, demonstrating the potential of this approach in cancer treatment.

ADVANCED MATERIALS (2022)

Article Chemistry, Multidisciplinary

In Situ Sprayed Starvation/Chemodynamic Therapeutic Gel for Post-Surgical Treatment of IDH1 (R132H) Glioma

Chunying Li et al.

Summary: The passage discusses a starvation/chemodynamic therapeutic gel developed to combat residual IDH1 (R132H) tumor cells after surgery, showing higher therapeutic efficacy towards IDH1 (R132H) cells compared to IDH1 (WT) cells and achieving long-term survival through catalyzing oxidation processes to kill cells.

ADVANCED MATERIALS (2022)

Article Chemistry, Multidisciplinary

Two-Pronged Intracellular Co-Delivery of Antigen and Adjuvant for Synergistic Cancer Immunotherapy

Junli Meng et al.

Summary: Nanovaccines that can co-deliver antigen and adjuvant to dendritic cells have emerged as effective tools for activating antitumor immune responses, inhibiting tumor growth, and improving survival rates.

ADVANCED MATERIALS (2022)

Review Engineering, Multidisciplinary

Fabrication of subunit nanovaccines by physical interaction

HaoLin Chen et al.

Summary: Vaccines can improve human life by preventing infectious diseases and can also be used for tumor prevention and treatment. Subunit vaccines, which have antigens in the form of proteins or peptides, offer safety to recipients but have relatively low immunogenicity. Nanoparticular delivery systems and molecular adjuvants can enhance the immunocompetence of subunit vaccines.

SCIENCE CHINA-TECHNOLOGICAL SCIENCES (2022)

Review Engineering, Multidisciplinary

Recent advances in organic and polymeric carriers for local tumor chemo-immunotherapy

YiTing Bai et al.

Summary: Combination therapy involves using compounds with different mechanisms of action to improve antitumor treatment efficacy and reduce toxicity. The most commonly used combination is chemotherapy combined with immunotherapy, which induces tumor cell apoptosis and activates immune responses. The advancement of micro/nanotechnology, nanomedicine, and biomaterials has led to the development of enhanced local drug delivery systems for cancer treatment, improving tumor targeting and reducing systemic complications.

SCIENCE CHINA-TECHNOLOGICAL SCIENCES (2022)

Review Chemistry, Multidisciplinary

Manipulating Intratumoral Fenton Chemistry for Enhanced Chemodynamic and Chemodynamic-Synergized Multimodal Therapy

Yaofeng Zhou et al.

Summary: Various strategies have been developed to increase the efficiency of the intratumoral Fenton reaction in chemodynamic therapy (CDT), enhancing the therapeutic efficacy. The introduction of reinforcement strategies can improve treatment efficiency and promote the development of enhanced CDT-based multimodal anticancer therapies.

ADVANCED MATERIALS (2021)

Review Chemistry, Multidisciplinary

Recent Strategies to Develop Innovative Photosensitizers for Enhanced Photodynamic Therapy

Thanh Chung Pham et al.

Summary: This review presents a robust strategy for designing photosensitizers for different species, highlighting the importance of organic PSs in photodynamic therapy. While previous studies have focused on nanomaterials and traditional PSs, this review sets out to report recent innovative strategies for developing organic photosensitizers for enhanced PDT, providing detailed examples to offer intuitive and specific insights to readers.

CHEMICAL REVIEWS (2021)

Review Chemistry, Multidisciplinary

Janus Nanoparticles: From Fabrication to (Bio)Applications

Xuan Zhang et al.

Summary: Janus nanoparticles have attracted significant interest due to their unique characteristics and diverse applications. Through classification, fabrication strategies, and applications, recent progress in this field has been comprehensively presented.

ACS NANO (2021)

Article Chemistry, Multidisciplinary

Zoledronic Acid-Gadolinium Coordination Polymer Nanorods for Improved Tumor Radioimmunotherapy by Synergetically Inducing Immunogenic Cell Death and Reprogramming the Immunosuppressive Microenvironment

Zhusheng Huang et al.

Summary: The self-assembled carrier-free coordination polymer nanorods can enhance reactive oxygen species production and induce cell death while depleting tumor-associated macrophages, improving the tumor microenvironment and boosting immune responses to enhance the efficacy of immunotherapy against tumors.

ACS NANO (2021)

Article Pharmacology & Pharmacy

Self-assembled FeS-based cascade bioreactor with enhanced tumor penetration and synergistic treatments to trigger robust cancer immunotherapy

Hao Ren et al.

Summary: The self-assembled cascade bioreactor enhances tumor penetration and primary tumor elimination through synergistic therapy, while also promoting immunogenic cell death. This novel treatment strategy has promising potential for inhibiting primary tumors and metastasis.

ACTA PHARMACEUTICA SINICA B (2021)

Article Chemistry, Multidisciplinary

Degradable one-dimensional dextran-iron oxide nanohybrids for MRI-guided synergistic gene/photothermal/magnetolytic therapy

Nana Zhao et al.

Summary: The one-dimensional polycation-coated nanohybrids Fe3O4@Dex-PGEA exhibit good cellular uptake efficiency and excellent anticancer effect. Utilizing efficient delivery, the anti-oncogene p53-loaded nanoplatform shows a tri-modal gene/photothermal/magnetolytic synergistic effect in vitro and in vivo. The pH-responsive degradability of the nanohybrids allows for efficient and rapid clearance in vivo.

NANO TODAY (2021)

Article Chemistry, Multidisciplinary

A multimodal strategy of Fe3O4@ZIF-8/GOx@MnO2 hybrid nanozyme via TME modulation for tumor therapy

Yu Zhang et al.

Summary: A new hybrid nanozyme was studied, which can improve the H2O2 concentration and acidity in the tumor microenvironment through magnetic targeting and photothermal effect, thus realizing multiple therapeutic modes for tumor therapy.

NANOSCALE (2021)

Review Chemistry, Multidisciplinary

Understanding nanoparticle endocytosis to improve targeting strategies in nanomedicine

Mauro Sousa de Almeida et al.

Summary: Nanoparticles have diverse applications, particularly in nanomedicine for detecting and treating diseases like cancer and inflammation. Understanding the mechanisms of cellular uptake and intracellular localization of nanoparticles is crucial for therapeutic applications. Factors such as physicochemical properties, endocytic pathways, and cellular uptake regulators play key roles in the application of nanoparticles in medicine.

CHEMICAL SOCIETY REVIEWS (2021)

Review Chemistry, Multidisciplinary

Second near-infrared photothermal materials for combinational nanotheranostics

Cheng Xu et al.

Summary: Second near-infrared photothermal therapy (NIR-II PTT) has advantages of deeper penetration and less toxicity, but faces challenges of suboptimal photothermal conversion and limited therapeutic efficacy. To improve efficacy, multifunctional NIR-II photothermal inorganic or organic materials have been developed for combination with other therapeutic modalities.

CHEMICAL SOCIETY REVIEWS (2021)

Article Nanoscience & Nanotechnology

Polycation-Carbon Nanohybrids with Superior Rough Hollow Morphology for the NIR-II Responsive Multimodal Therapy

Nana Zhao et al.

ACS APPLIED MATERIALS & INTERFACES (2020)

Article Chemistry, Multidisciplinary

Co-Ferrocene MOF/Glucose Oxidase as Cascade Nanozyme for Effective Tumor Therapy

Chao Fang et al.

ADVANCED FUNCTIONAL MATERIALS (2020)

Article Multidisciplinary Sciences

The pore size of mesoporous silica nanoparticles regulates their antigen delivery efficiency

Xiaoyu Hong et al.

SCIENCE ADVANCES (2020)

Review Immunology

A guide to cancer immunotherapy: from T cell basic science to clinical practice

Alex D. Waldman et al.

NATURE REVIEWS IMMUNOLOGY (2020)

Review Immunology

Dendritic cells in cancer immunology and immunotherapy

Stefanie K. Wculek et al.

NATURE REVIEWS IMMUNOLOGY (2020)

Review Chemistry, Multidisciplinary

Nanoparticle-Mediated Immunogenic Cell Death Enables and Potentiates Cancer Immunotherapy

Xiaopin Duan et al.

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2019)

Article Chemistry, Multidisciplinary

Mechanism of Iron Oxide-Induced Macrophage Activation: The Impact of Composition and the Underlying Signaling Pathway

Zhengying Gu et al.

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2019)

Article Chemistry, Multidisciplinary

Nanocatalytic Tumor Therapy by Biomimetic Dual Inorganic Nanozyme-Catalyzed Cascade Reaction

Shanshan Gao et al.

ADVANCED SCIENCE (2019)

Review Oncology

Improving cancer immunotherapy through nanotechnology

Michael S. Goldberg

NATURE REVIEWS CANCER (2019)

Review Materials Science, Biomaterials

Janus nanoparticles in cancer diagnosis, therapy and theranostics

Yifan Zhang et al.

BIOMATERIALS SCIENCE (2019)

Review Chemistry, Multidisciplinary

Construction of iron oxide nanoparticle-based hybrid platforms for tumor imaging and therapy

Yong Hu et al.

CHEMICAL SOCIETY REVIEWS (2018)

Review Chemistry, Multidisciplinary

Catalytic chemistry of glucose oxidase in cancer diagnosis and treatment

Lian-Hua Fu et al.

CHEMICAL SOCIETY REVIEWS (2018)

Article Chemistry, Multidisciplinary

Tumor Starvation Induced Spatiotemporal Control over Chemotherapy for Synergistic Therapy

Ming-Kang Zhang et al.

SMALL (2018)

Article Chemistry, Multidisciplinary

Asymmetric Silica Nanoparticles with Tunable Head-Tail Structures Enhance Hemocompatibility and Maturation of Immune Cells

Prasanna Lakshmi Abbaraju et al.

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2017)

Article Chemistry, Multidisciplinary

Hollow Nanostars with Photothermal Gold Caps and Their Controlled Surface Functionalization for Complementary Therapies

Ranran Wang et al.

ADVANCED FUNCTIONAL MATERIALS (2017)

Article Chemistry, Multidisciplinary

Magnetic-mesoporous Janus nanoparticles

Lu Zhang et al.

CHEMICAL COMMUNICATIONS (2011)