Hole behavior captured by analysis of instantaneous amplitude and phase of sarcosynced oscillations reveals wave characteristics of sarcomeric oscillations

Article Biochemistry & Molecular Biology

Hyperthermal sarcomeric oscillations generated in warmed cardiomyocytes control amplitudes with chaotic properties while keeping cycles constant

Seine A. Shintani

Summary: This study found that during high-frequency contraction oscillations (HSOs), the oscillation amplitude of sarcomeres fluctuates chaotically while the oscillation cycle remains constant. Sarcomeres can flexibly adjust their synchronization state in response to changes in calcium concentration, and the tension of sarcomeres primarily depends on the cycle of calcium concentration.

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2022)

Add to Collection

Editorial Material Physiology

Does the Hyperthermal Sarcomeric Oscillations Manifested by Body Temperature Support the Periodic Ventricular Dilation With Each Heartbeat?

Seine A. Shintani

FRONTIERS IN PHYSIOLOGY (2022)

Add to Collection

Article Physiology

A thermodynamically consistent monte carlo cross-bridge model with a trapping mechanism reveals the role of stretch activation in heart pumping

Kazunori Yoneda et al.

Summary: Changes in intracellular calcium concentrations regulate heartbeats, with stretch activation in cardiac muscles playing a crucial role in the pumping function of the heart. The delayed force in stretch activation leads to sustained contraction forces and synchronized degeneration, resulting in a larger blood ejection during the heart's pumping cycle.

FRONTIERS IN PHYSIOLOGY (2022)

Add to Collection

Article Biophysics

Effects of high-pressure treatment on the structure and function of myofibrils

Seine A. Shintani

Summary: High pressure was found to affect the structure and function of myofibrils, leading to shortening and widening of the A band and structural loss in certain cases. Despite structural damage, sarcomeric oscillation could still be induced, with a decrease in total power but no change in average frequency. Restoring the original pressure also restored the average frequency.

BIOPHYSICS AND PHYSICOBIOLOGY (2021)

Add to Collection

Article Multidisciplinary Sciences