Propylene carbonate as an ecofriendly solvent: Stability studies of Ripretinib in RPHPLC and sustainable evaluation using advanced tools

Ripretinib (RPB) is a U.S. Food and Drug Administration approved drug for the treatment of advanced gastrointestinal stromal tumour. According to literature search, there are no RP-HPLC methods developed for the recently approved drug RPB due to its terrible solubility. In this current study, Green Analytical Chemistry (GAC) was employed using the RP-HPLC technique to study the stability of RPB under different stress conditions. Two reported polymorphs of RPB were analysed using the mobile phase mixture of phosphate buffer, propylene carbonate and ethanol (50: 35: 15) on a 250 x 4.6 mm, i.d. 5 mu m Inertsil ODS-2 C18 column, at a wavelength of 260 nm. In this study, method development for RPB quantification was accomplished within a linearity range of 1400-2600 ng/mL, yielding an R2 value of 0.9973. The method exhibited a LOD of 103 ng/mL and a LOQ of 312 ng/mL, demonstrating high sensitivity and accuracy. The utilization of assessment tools for evaluating greenness and whiteness offered valuable insights into the environmental impact and sustainability of the proposed methodology. The results substantiated its positive performance in terms of eco-friendliness, thereby emphasizing its alignment with seven sustainable development goals include 7 (Affordable and Clean Energy), 9 (Industry, Innovation, and Infrastructure), 12 (Responsible Consumption and Production), 13 (Climate Action), 14 (Life Below Water), 15 (Life on Land), 17 (Partnerships for the Goals). This further enhances the credibility and significance of the developed method in advancing the cause of a greener and more sustainable future.

Automated summary

This study employed Green Analytical Chemistry (GAC) and RP-HPLC technique to investigate the stability of Ripretinib under different stress conditions and developed a highly sensitive and accurate RP-HPLC method. The method's environmentally friendly performance was validated and aligned with several sustainable development goals, further enhancing its credibility and significance in advancing a greener and more sustainable future.