Journal
ACS APPLIED MATERIALS & INTERFACES
Volume 15, Issue 50, Pages 58251-58259Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acsami.3c15463
Keywords
chiral nanoparticles; antiviral; porcine reproductiveand respiratory syndrome virus; chiral zinc oxide; reactive oxygen species
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Chiral ZnO nanoparticles show outstanding antiviral properties, with their mechanism of action mainly related to cell adhesion and uptake.
Chiral nanoparticles (C-NPs) play a crucial role in biomedical applications, especially in their biological effects on cytotoxicity and metabolism. However, there are rare reports about the antivirus property of C-NPs and their working mechanism. Here, three different types of chiral ZnO NPs (l-ZnO, d-ZnO, and dl-ZnO) were prepared as enantioselective antivirals. Biocompatibility test results showed that the three different chiral ZnO NPs varied significantly in cytotoxicity. Evaluation of their effects against porcine reproductive and respiratory syndrome virus (PRRSV) indicated that compared with d-ZnO and dl-ZnO NPs, l-ZnO NPs exhibited stronger anti-PRRSV activity due to their higher cognate cell adhesion and uptake. Furthermore, the high concentration of l-ZnO NPs can obviously reduce cellular reactive oxygen species (ROS) in MARC-145 cells, thus effectively preventing PRRSV-induced oxidative damage. This study demonstrated the outstanding antiviral properties of l-ZnO NPs, which may facilitate the development and application of C-NPs in antiviral drugs and tissue engineering.
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